Bone Mineral Density in Women with Depression

Michelson, David; Stratakis, Constantine A.; Hill, Lauren; Reynolds, James C.; Galliven, Elise; Chrousos, George P.; Gold, Philip W.

doi:10.1056/nejm199610173351602

Cited by 415 publications

(299 citation statements)

References 26 publications

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“…To date, the evidence supporting an influence of depression on changes in BMD in postmenopausal women has not been uniformly strong. A few small cross-sectional and case-control studies reported an inverse association between clinically diagnosed depression and femoral or spinal BMD, 14,35,36 whereas a larger cross-sectional study found no association. 37 A recent 1-year longitudinal study of 320 postmenopausal white women (average age 56 years) did not observe an association between depressive symptoms and BMD loss at the more trabecular spine.…”

Section: Discussion Bmd Changementioning

confidence: 97%

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Depressive Symptoms, Bone Loss, and Fractures in Postmenopausal Women

et al. 2008

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Section: Discussion Bmd Changementioning

confidence: 97%

“…14 They observed an association between clinically assessed depression and lower bone mineral density (BMD) and higher urinary cortisol excretion in premenopausal women. Prospective studies are limited.…”

Section: Introductionmentioning

confidence: 99%

Depressive Symptoms, Bone Loss, and Fractures in Postmenopausal Women

et al. 2008

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“…In total, 21 articles complied with these criteria (Michelson et al. 1996; Amsterdam and Hooper 1998; Whooley et al. 1999, 2004; Robbins et al.…”

Section: Methodsmentioning

confidence: 99%

Bone density and depressive disorder: a meta‐analysis

Schweiger

Hüppe

et al. 2016

Brain and Behavior

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BackgroundThe aim of this study was to evaluate the evidence of low bone mineral density (BMD) in depression. Low BMD is a major risk factor for osteoporotic fractures and frailty.MethodsThe searched database was Pubmed, Meta‐analysis included human studies in men and women fulfilling the following criteria: (1) assessment of BMD in the lumbar spine, the femur or the total hip; (2) comparison of BMD between depressed individuals and the healthy control group; (3) measurement of BMD using dual‐energy X‐ray absorptiometry (DEXA); and (4) data on the mean, standard deviation, or standard error of BMD.ResultsTwenty‐one studies were identified, encompassing 1842 depressed and 17,401 nondepressed individuals. Significant negative composite weighted mean effect sizes were identified for the lumbar spine (d = −0.15, 95%CL −0.22 to −0.08), femur (d = −0.34, 95%CL −0.64 to −0.05), and total hip (d = −0.14, 95%CL −0.23 to −0.05) indicating low BMD in depression. Examining men and women shows low bone density in the lumbar spine and femur in women and low bone density in the hip in men. The differences between men and women with MDD and the comparison group tended to be higher when examined by expert interviewers. Low bone density was found in all age groups.ConclusionsBone mineral density is reduced in patients with depressive disorders. The studies provide little evidence for potential relevant mediating factors.

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“…Dados da literatura indicam que a depressão está associada à menor densidade óssea 7,8 , sendo este um dos fatores de risco para a fratura de quadril, fornecendo, assim, fundamentação teórica para uma possível associação entre depressão e maior risco para a fratura. Desse modo, a depressão via aumento do cortisol 7 conduziria a desmineralização óssea e, consequentemente, maior risco para a fratura.…”

Section: Discussão E Conclusõesunclassified