Bone Mineral Density in the Noninstitutionalized Elderly: Influence of Sociodemographic and Anthropometric Factors

Araujo, Ellen Cristina de Sousa e Silva; Pagotto, Valéria; Silveira, Érika Aparecida

doi:10.1155/2016/4946593

Cited by 4 publications

(4 citation statements)

References 23 publications

(43 reference statements)

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“…Age is an evident nonmodifiable primary risk factor for osteoporosis. 1 , 11 - 14 This was proven in this study as it remained significantly associated with an increased risk of osteoporosis regardless of the genotype. The capacity of the bone tissue to synthesize bone decreases as age increases.…”

Section: Discussionsupporting

confidence: 58%

“…The capacity of the bone tissue to synthesize bone decreases as age increases. 14 Several combined factors including hormonal, biochemical, genetic, and environmental factors trigger bone loss attributed to age. 44 …”

Section: Discussionmentioning

confidence: 99%

“…BMD is a valuable clinical diagnostic index for osteoporosis and the best tool for osteoporotic fracture prediction. 7 - 10 Osteoporosis is associated with several genetic and nongenetic factors, 1 , 3 some of which include age, 1 , 11 - 14 sex, 1 - 3 menopausal status, 1 - 3 , 15 educational level, 11 , 12 , 14 , 16 coffee drinking, 11 smoking, 1 , 2 , 12 exercise, 1 , 2 , 12 alcohol consumption, 1 , 2 , 12 diet, 1 , 2 , 17 and body mass index (BMI). 1 , 11 , 13 , 14 , 18 …”

mentioning

confidence: 99%

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Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women

et al. 2020

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Objective: Osteoporosis, the most prevalent bone disorder in humans, is a global public health issue and its relationship with menopause is well-established. The interaction between menopause and genes on osteoporosis risk is, however, yet to be fully elucidated. We assessed the association between menopause and osteoporosis in relation to the SOX6 rs297325 variant in Taiwanese women. Methods: There were 7,581 female participants, aged 30 to 70 years old. Information on SOX6 rs297325 and menopause were obtained from the Taiwan Biobank Database while that on osteoporosis was obtained from the National Health Insurance Research Database. Results: Menopause but not SOX6 rs297325 was significantly associated with a higher risk of osteoporosis (odds ratio [OR] = 1.48; 95% confidence interval [CI] = 1.04-2.10). The interaction between menopause and rs297325 on osteoporosis was significant ( P = 0.0216). After stratification by rs297325 genotypes, the risk of osteoporosis was significantly higher in menopausal women having the TT + CC genotype (OR = 2.02; 95% CI = 1.21-3.38). After stratification by menopausal status and rs297325 genotypes, the OR; 95% CI was 0.62; 0.38 to 0.99 in premenopausal women with the TC + CC genotype and 1.24; 0.82 to 1.88 in menopausal women with the TC + CC genotype. Conclusion: SOX6 rs297325 was not significantly associated with osteoporosis but might have modulated the association between menopause and osteoporosis. The risk of osteoporosis was higher in menopausal women with the TC + CC genotype but lower in premenopausal women with the TC + CC genotype.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women

et al. 2020

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“…Several risk factors are attributed to low bone mass. Age at menarche, age at menopause, older age, height and BMI have been recognized as risk factors for low BMD(38)(39)(40). Age at menarche and at menopause had been known to have a relationship with osteoporosis gene polymorphisms (RANK gene)(41).…”

mentioning

confidence: 99%

Polymorphisms within RANKL and Osteoprotegerin Genes in Low Bone Mass among Postmenopausal Indonesian Women

Haryono

Tulaar²,

Sudoyo

et al. 2019

Tod

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Amaç: Reseptör aktivatör nükleer faktör-B ligandı (RANKL) ve osteoprotegerinin (OPG) kemik yeniden modelleme ve osteoporozda önemli bir rolü olduğu gösterilmiştir. Bu çalışmada, Endonezya menopoz sonrası kadınlarda düşük kemik mineral yoğunluğu (KMY) ile RANKL ve OPG genlerinin polimorfizmleri (sırasıyla TNFSF11 ve TNFRSF11B) arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Elli-altmış beş yaş arası 60 postmenopozal kadın uygun bulundu. KMY, çift-enerjili X-ışını absorpsiyometrisi kullanılarak ölçülmüştür. TNFSF11 ve TNFRSF11B'nin genotipleri polimeraz zincir reaksiyonu-kısıtlama fragman uzunluğu polimorfizmleri ve DNA dizileme yöntemleri ile elde edildi. TNFSF11'den (-290C> T,-643C> T,-693G> C) ve TNFRSF11B'den (163A>G, 950T>C, 1181G>C) üç tek nükleotid polimorfizmleri (SNP) seçildi. Allel dağılımı ile KMY arasındaki ilişki ki-kare veya Fischer kesin testi kullanılarak hesaplandı. Kemik bölgelerindeki tüm SNP'leri ve BMD'yi analiz etmek için çoklu lojistik regresyon kullanıldı. Anlamlılık p<0,05 olarak ayarlandı. Bulgular: Çoğu birey daha düşük KMY'ye (%83,3) sahipti. Sağlıklı ve düşük KMY arasındaki bireylerin özellikleri karşılaştırılabilir bulundu (hepsi p>0,05). TNSSF11 ve TNFRSF11B'de genotiplerin ve allellerin sağlıklı ve düşük KMY'ler arasındaki dağılımı anlamlı olarak farklı değildi (hepsi p>0,05). Tüm kemik bölgelerinde TNFSF11 ve TNFRSF11B'nin SNP'leri ile KMY arasında ilişki yoktu (hepsi p>0,05). Objective: Prior studies have shown that receptor activator of nuclear factor-B ligand (RANKL) and osteoprotegerin (OPG) have an essential role in bone remodeling and osteoporosis. This study aimed to investigate the association between RANKL (TNFSF11) and OPG (TNFRSF11B) genes' polymorphisms with low bone mineral density (BMD) in Indonesian postmenopausal women. Materials and Methods: Sixty postmenopausal women aged between 50-65 years were eligible. The BMD was measured by using dualenergy X-ray absorptiometry. The genotypes of TNFSF11 and TNFRSF11B were obtained by polymerase chain reaction-restriction fragment length polymorphisms and DNA sequencing methods. Three single nucleotide polymorphisms (SNPs) from TNFSF11 (-290C>T,-643C>T,-693G>C) and from TNFRSF11B (163A>G, 950T>C, 1181G>C) were selected. The association between alleles distribution and BMD was computed using chi-square or Fischer's exact test. Multiple logistic regression was used to analyze between all SNPs and BMD at bone sites. Significance was set at p<0.05. Results: Most subjects had lower BMD (83.3%). Characteristics of subjects between healthy and low BMD were comparable (all p>0.05). The distribution of genotypes and alleles in TNSSF11 and TNFRSF11B between healthy and low BMD were not significantly different (all p>0.05). There was no association between SNPs of TNFSF11 and TNFRSF11B with BMD at all bone sites (all p>0.05). Conclusion: The present study suggests that TNFSF11 and TNFRSF11B gene polymorphisms are not associated with BMD in Indonesian postmenopausal women aged between 50-65 years old.

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Osteosarcopenia later in life: Prevalence and associated risk factors

Silveira,

Vinícius-Souza,

Pereira

et al. 2023

Clinical Nutrition ESPEN

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Bone Mineral Density in the Noninstitutionalized Elderly: Influence of Sociodemographic and Anthropometric Factors

Cited by 4 publications

References 23 publications

Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women

Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women

Polymorphisms within RANKL and Osteoprotegerin Genes in Low Bone Mass among Postmenopausal Indonesian Women

Osteosarcopenia later in life: Prevalence and associated risk factors

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