Bone Mineral Density in Prediabetic Men

Lee, Yun Hyeong; Jung, Kyoung Hye; Kim, Min Kyeong; Jang, Hye Won; Kim, Tae Kyun; Kim, Hyun Jin; Jo, Young Suk; Shong, Minho; Lee, Tae Yong; Ku, Bon Jeong

doi:10.4093/kdj.2010.34.5.294

Cited by 20 publications

(19 citation statements)

References 26 publications

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“…Additionally, in this study, QUS parameters and the T-score positively correlated with BMI and WHR. Similar findings were reported in other studies, as QUS parameters were inversely correlated with age and positively correlated with weight and BMI; however, no correlation was found with height [ 92 , 93 ].…”

Section: Discussionsupporting

confidence: 90%

The Prevalence of Osteopenia and Osteoporosis Among Malaysian Type 2 Diabetic Patients Using Quantitative Ultrasound Densitometer

Abdulameer¹,

Sahib²,

Sulaiman³

2018

TORJ

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Background:Type 2 Diabetes Mellitus (T2DM) and osteoporosis are both chronic conditions and the relationship between them is complex.Objective:The aims of this study were to assess the prevalence of Low Bone Mineral density (LBMD, i.e., osteopenia and osteoporosis), as well as, the difference and associations between Quantitative Ultrasound Scan (QUS) parameters with socio-demographic data and clinical related data among T2DM in Penang, Malaysia.Method:An observational, cross-sectional study with a convenient sample of 450 T2DM patients were recruited from the outpatient diabetes clinic at Hospital Pulau Pinang (HPP) to measure Bone Mineral Density (BMD) at the heel bone using QUS. In addition, a self-reported structured questionnaire about the socio-demographic data and osteoporosis risk factors were collected. Moreover, the study included the retrospective collection of clinical data from patients’ medical records.Results:The mean value of T-score for normal BMD, osteopenic and osteoporotic patients’ were (-0.41±0.44), (-1.65±0.39) and (-2.76±0.27), respectively. According to QUS measurements, more than three quarters of T2DM patients (82%) were at high risk of abnormal BMD. The results showed that QUS scores were significantly associated with age, gender, menopausal duration, educational level and diabetic related data. Moreover, the QUS parameters and T-scores demonstrated significant negative correlation with age, menopausal duration, diabetic duration and glycaemic control, as well as, a positive correlation with body mass index and waist to hip ratio. The current study revealed that none of the cardiovascular disease risk factors appear to influence the prevalence of low BMD among T2DM Malaysian patients.Conclusion:The study findings revealed that the assessment of T2DM patients’ bone health and related factor are essential and future educational programs are crucial to improve osteoporosis management.

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Section: Discussionsupporting

confidence: 90%

The Prevalence of Osteopenia and Osteoporosis Among Malaysian Type 2 Diabetic Patients Using Quantitative Ultrasound Densitometer

Abdulameer¹,

Sahib²,

Sulaiman³

2018

TORJ

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“…This result is consistent with some previous studies. Firstly, Lee et al found no association between any prediabetes criteria and BMD in adult subjects (13). Another study in adolescent children with metabolic syndrome failed to show a relationship between glucose levels and BMD (18).…”

Section: Discussionmentioning

confidence: 98%

“…However, this conflict also exists among prediabetic patients. Whereas some studies report a positive association between prediabetes and bone mineral content or (BMC) (9,10), others suggest an inverse association (11,12) or no significant relationship (13). We aimed to investigate the relation between BMD and childhood obesity, and assess the effect of prediabetes on this relationship.…”

Section: Introductionmentioning

confidence: 99%

Prediyabeti olan obez çocukların kemik mineral dansitometreleri

Üstyol

Atabek

2018

Ege Tıp Dergisi

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The aim of this study was to evaluate the relationships between bone mineral density (BMD) vs metabolic risk factors in obese adolescents with prediabetes. Materials and Methods: A total of 131 obese children and adolescents, aged 6-18 years of age were enrolled the study. Prediabetes was determined by a fasting blood glucose level of ≥100 to 125 mg/dL or 2-hour oral glucose tolerance test value of ≥140 to 199 mg/dL. Five patients who were diagnosed as having type 2 diabetes were excluded and remaining participants were classified as normal glucose tolerance (NGT) and prediabetic. BMD was measured on calcaneus using quantitative ultrasound. BMD and metabolic parameters were investigated and compared in these two groups. Results: There was no significant difference in BMD between children and adolescents with prediabetes (n = 37) or NGT (n = 89). The parameters of prediabetes did not affect BMD and these results did not change when we adjusted for weight, height, age, sex, pubertal status. The multivariate linear regression analysis revealed that the only independent factor associated with higher BMD was higher BMI (OR=0.007 95%CI 0.002-0.013 p=0.013). No significant associations were found between BMD and waist circumference or biochemical measurements. Conclusion: Plasma glucose within the prediabetic range is not associated with bone mineral density in obese children. Thus, the positive association of BMI with BMD may be by means of alternative pathways.

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“…Стоит отметить, что хроническое воспаление усиливает агрегацию β-амилоида, который в сочетании с нарушением инсулин-сигнальной трансдукции снижает транспорт и утилизацию глюкозы в головном мозге, активирует гликогенсинтаз-киназы 3 (GSK3), что увеличивает гиперфосфорилирование тау-белка, в конечном итоге, приводя к нейродегенерации [23]. В дополнение к этому, воспалительные цитокины, экспрессируемые в ответ на активность инфламмасом NLRP3, вносят решающий вклад в развитие резистентности к инсулину путем активации различных киназ, тем самым нарушая передачу сигналов инсулина [15].…”

Section: статистический анализunclassified