Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk

Gui, Jicong; Brašić, James Robert; Liu, X.-D.; Gong, Gordon; Zhang, G.-M.; Liu, C.-J.; Gao, Guanghui

doi:10.1007/s00198-012-1895-z

Cited by 45 publications

(45 citation statements)

References 38 publications

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“…Similar effects of calcium and/or vitamin D fortified milk on bone parameters have been observed in Asian populations. A 16-weeks calcium or calcium/ vitamin D fortified milk trial in post-menopausal Asian women demonstrated reductions in PTH and bone turnover of about 10% and ≥ 20% respectively [25,26]. Two longer term intervention studies with a duration between 18 and 30 months using vitamin D fortified dairy with or without calcium have shown beneficial effects on bone turnover and/or total and site-specific BMD in postmenopausal women [26,27].…”

Section: Discussionmentioning

confidence: 99%

A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study

et al. 2019

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Alterations in musculoskeletal health with advanced age contribute to sarcopenia and decline in bone mineral density (BMD) and bone strength. This decline may be modifiable via dietary supplementation. To test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of bone health. Participants (n 380) were participants of the PROVIDE study, a 13-week, multicenter, randomized, controlled, double-blind, 2 parallel-group study among nonmalnourished older participants (≥ 65 years) with sarcopenia [determined by Short Physical Performance Battery (SPPB; 0-12) scores between 4 and 9, and a low skeletal muscle mass index (SMI; skeletal muscle mass/BW × 100) ≤ 37% in men and ≤ 28% in women using bioelectric impedance analysis] Supplementation of a vitamin D, calcium and leucine-enriched whey protein drink that comprises a full range of micronutrients (active; 2/day) was compared with an iso-caloric control. Serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), biochemical markers of bone formation (osteocalcin; OC, procollagen type 1 amino-terminal propeptide; P1NP) and resorption (carboxy-terminal collagen crosslinks; CTX), insulin like growth factor 1 (IGF-1) and total-body BMD were analysed pre-and post-intervention. Serum 25(OH) D concentrations increased from 51.1 ± 22.9 nmol/L (mean ± SD) to 78.9 ± 21.1 nmol/L in the active group (p < 0.001 vs. control). Serum PTH showed a significant treatment difference (p < 0.001) with a decline in the active group, and increase in the control group. Serum IGF-1 increased in the active group (p < 0.001 vs. control). Serum CTX showed a greater decline in the active group (p = 0.001 vs. control). There were no significant differences in serum OC or P1NP between groups during the intervention. Total body BMD showed a small (0.02 g/cm 2 ; ~ 2%) but significant increase in the active group after supplementation (p = 0.033 vs. control). Consuming a vitamin D, calcium and leucine-enriched whey protein supplement for 13 weeks improved 25(OH)D, suppressed PTH and had small but positive effects on BMD, indicative of improved bone health, in sarcopenic non-malnourished older adults.

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Section: Discussionmentioning

confidence: 99%

A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study

et al. 2019

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“…Supplementation of as low as 500 mg of calcium could effectively slow lumbar spine bone loss in Japanese perimenopausal women with low calcium intake [Nakamura et al, ]. Similar beneficial effects have been observed in postmenopausal women from Hong Kong [Lau et al, ; Haines et al, ; Lee et al, ; Lau et al, ; Ho et al, ], China [Gui et al, ], Chile [Rodriguez and Novik, ], Argentina [Malpeli et al, ] and Nigeria [Umaretiya et al, ]. Interestingly, however, calcium supplementation failed to produce consistent effects on BMD in studies from calcium sufficient areas [Aloia et al, ; Chevalley et al, ; Barger‐Lux et al, ].…”

Section: Implications In Global Health Perspectives – Fracture and Camentioning

confidence: 90%

Calcium, Is It Better to Have Less?—Global Health Perspectives

Shin

Kim

2015

J of Cellular Biochemistry

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Appropriate calcium intake is necessary for the accrual and maintenance of bone mass. A significant proportion of the world's population does not have adequate calcium intake, and thus, supplementation plays a key role in maintaining bone homeostasis and other aspects of health. Since a series of reports from the Auckland calcium study and meta-analysis indicated that calcium supplementation was associated with an increased risk for adverse cardiovascular events, concern over the safety of calcium supplementation has grown; however, considerable inconsistencies in the reproducibility were found and questions regarding the study methodologies have been raised. In addition, since the increased adverse cardiovascular events by calcium supplementation were observed in calcium-replete subjects, it should be clarified whether the same risk profile would be observed in countries with low calcium intake. Dietary calcium intake varies widely across the world; cardiovascular event risk factors and outcomes also vary and appear to be the opposite of calcium intake levels. Furthermore, the effects of calcium supplementation were shown to depend on dietary calcium intake, with a better bone mineral density response for low calcium intake subjects compared to that in calcium-replete subjects. Based on these evidences, the risk-benefit ratio of calcium supplement is likely to be different in different region of the world. Therefore, accumulation of evidence to establish population-specific guidelines for calcium supplementation is warranted before extrapolating the results obtained from a limited number of studies to the other people with different age, gender, ethnicity and risk profile across the world.

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“…1 Low calcium intake has been associated with lower bone density in some cross-sectional studies, [4][5][6] though not all. 7 Interventions to increase calcium intake in postmenopausal women have shown beneficial effects on bone density, [8][9][10] though in some studies the benefit Gastrointestinal complaints are common with calcium supplements and can be mitigated with osmotic cathartics (mixed in the same pill or not) or with dose adjustment.…”

Section: ■ Calcium Intake and Bone Densitymentioning

confidence: 99%

Optimizing calcium and vitamin D intake through diet and supplements

Kilim

Rosen

2018

CCJM

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Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk

Abstract: Daily consumption of milk containing 250 mg calcium over 18 months prevents BMD loss at the hip and the femoral neck in postmenopausal Chinese women.

Cited by 45 publications

References 38 publications

A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study

A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study

Calcium, Is It Better to Have Less?—Global Health Perspectives

Optimizing calcium and vitamin D intake through diet and supplements

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