Bone Mineral Density in Patients on Maintenance Hemodialysis and Effect of Chronic Hepatitis C Virus Infection

Yücel, Ahmet Eftal; Hamide, Kart-Koseoglu; Işıklar, I.; Kuruinci, E.; Özdemir, F.N.; Arslan, Hande

doi:10.1081/jdi-120038501

Cited by 19 publications

(17 citation statements)

References 23 publications

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“…In this bone DXA densitometry-based study, we detected that osteoporosis was common in dialysis patients, observed in 23% of cases. Indeed, literature data showed that the prevalence of osteoporosis varied from 4 to 47% at the lumbar spine and from 10 to 64% at the femoral site [7][8][9][10][11][12][13][14][15]. Moreover, Avramovski et al [16] demonstrated that the progression of bone mass loss was significantly greater in chronic hemodialysis patients than in general population patients.…”

Section: Discussionmentioning

confidence: 99%

Mineral bone disorder and osteoporosis in hemodialysis patients

et al. 2020

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Background: Bone disease is common in patients undergoing hemodialysis. It is the result of bone turnover abnormalities and the decrease of bone mineral density (BMD). We aimed to determine the usefulness of serum bone turnover markers and BMD measurement by dual-energy x-ray absorptiometry (DXA) in hemodialysis patients. Methods: We conducted a cross-sectional study including 90 hemodialysis for more than 12 months. Bone mineral density was assessed by DXA. Peripheral blood samples were obtained from each patient before dialysis in a fasting state within a week of the DXA. Biochemical variables of calcium and phosphate were measured. One bone formation marker (bone-specific alkaline phosphatase (bAP), one bone resorption marker (carboxy-terminal telopeptides of type 1 collagen (CTX)) were measured. Total alkaline phosphatase (TAP), intact parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) which is a bone-derived hormone were also measured. Results: CTX values were 6.25 times higher than the normal limit of the assay. Bone alkaline phosphatase levels were less than 10 ng/mL in 28.8% of cases. 23% of patients have osteoporosis and 45% have osteopenia. Femoral BMD had negative correlations with age and PTH levels. FGF23 levels were significantly increased in patients with osteoporosis affecting the lumbar. The levels of bAP and CTX showed a positive correlation. Both circulating bAP and CTX levels showed also positive correlations with PTH levels. Fractures, observed in 12.2% of cases, were associated with low PTH values and the existence of osteoporosis. Conclusions: Our study showed that osteoporosis and fracture are common in dialysis patients. The reduced BMD was associated with advanced age and elevated levels of PTH. Markers of bone turnover and FGF23 may play a role in the diagnosis of bone disease in hemodialysis patients. DXA measurement is necessary for the monitoring for bone loss.

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Section: Discussionmentioning

confidence: 99%

Mineral bone disorder and osteoporosis in hemodialysis patients

et al. 2020

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“…The incidence of musculoskeletal problems increases with time on dialysis [14]. In addition to this, malnutrition may also frequently affect the health status of the dialysis patients [15].…”

Section: Discussionmentioning

confidence: 99%

The Frequency of Fibromyalgia Syndrome and the Quality of Life in Patients with Peritoneal Dialysis

Okumuş¹,

Parpucu²,

Kocaoğlu³

et al. 2012

OJRA

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Objective: The aim of this study was to determine the frequency of fibromyalgia (FM) in patients on Peritoneal Dialysis (PD) and to investigate its impact on the quality of life of that population. Methods: A hundred and twenty four patients with end stage renal disease who had undergone PD, and a control group of 54 age and sex-matched healthy volunteers were included to the study. Demographic characteristics including age, sex, disease and dialysis duration were recorded. Fibromyalgia Impact Questionnaire (FIQ) and Nottingham Health Profile (NHP) were also measured. Results: The mean age of the patients (68 female, 56 male) and control subjects (36 female, 18 male) were 43.5 ± 13.4 and 41.2 ± 9.2 years respectively. The prevalence of FM in the PD patients and controls were determined as 9.7% (12 patients) and 11.1% (6 controls) respectively and were found to be similar (p = 0.983). The mean score of subgroups of NHP except pain and emotion subgroups, were significantly higher in PD patients than in the control group. The mean FIQ levels, the scores of all the subgroups of NHP except the social subgroup were significantly higher in PD patients with FM than in those without FM. Conclusion: In conclusion although the prevalence of FM appears to be similar in PD patients and control subjects, the functional disability is common and quality of life is worse in PD patients with FM than in patients without FM. Detection and treatment of FM may lead to improvement in the quality of life of PD patients with this syndrome.

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“…3 In our study, because patients aged beyond 60 years was an exclusion criterion, we could not compare our results with those of Wolfe' s group. 27 In order to remove this confounding factor we paired the 2 groups according to length of therapy. Corroborating with our results are those of Yuceturk' s 23 which could reflect the studied population.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of musculoskeletal disturbances due to multifactorial causes rises with time on dialysis. 27 In order to remove this confounding factor we paired the 2 groups according to length of therapy. Other factors, such as the index of dialysis adequacy (Kt/V) and the body mass index were evaluated.…”

Section: Discussionmentioning

confidence: 99%

Fibromyalgia: Its prevalence and impact on the quality of life on a hemodialyzed population

Couto

Natour

Carvalho

2008

Hemodialysis International

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Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It has negative effects on quality of life and has been poorly investigated in specific populations. Our aim was to determine the prevalence of FMS in Brazilian hemodialysis (HD) patients and to investigate its effects on the quality of life. We investigated 311 patients on HD who were submitted to physical examination towards the classification of FMS. All subjects from FMS and control groups were submitted to laboratorial investigation and completed questionnaires of quality of life. The prevalence of FMS was 3.9%, which was close to that of the general population. Most patients were females and from non-Caucasian races. No difference between FMS and control groups was observed regarding race, dialysis adequacy, nutritional status and level of schooling. Ionized calcium was higher in the FMS group than in the control group. There was no association between FMS and secondary hyperparathyroidism. On the other hand, FMS was associated with worse quality of life, depression and anxiety. In conclusion, the prevalence of FMS in HD patients was similar to that of the general population. It was associated with decreasing quality of life in HD patients, in addition to higher degrees of depression and anxiety. No laboratory tests could identify FMS patients on HD. Fibromyalgia syndrome subsequently follows without a well-established mechanism of pathogenesis, and seems to be due to multifactorial causes. Its true impact on the quality of life of HD patients deserves more attention by nephrologists.

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Bone Mineral Density in Patients on Maintenance Hemodialysis and Effect of Chronic Hepatitis C Virus Infection

Abstract: However the mean BMD values for all three sites in the 76 HD patients were low HCV infection may not be a risk factor for low BMD in this population.

Cited by 19 publications

References 23 publications

Mineral bone disorder and osteoporosis in hemodialysis patients

Mineral bone disorder and osteoporosis in hemodialysis patients

The Frequency of Fibromyalgia Syndrome and the Quality of Life in Patients with Peritoneal Dialysis

Fibromyalgia: Its prevalence and impact on the quality of life on a hemodialyzed population

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