Bone Mineral Density in Healthy Female Adolescents According to Age, Bone Age and Pubertal Breast Stage

Oliveria, Maria Regina Moretto de; Silva, Carla Cristiane da; Kurokawa, Cilmery Suemi; Fortes, Cristina Maria Teixeira; Capela, Renata Campos; Teixeira, Altamir Santos; Dalmas, José Carlos; Goldberg, Tamara Beres Lederer

doi:10.2174/1874325001105010324

Cited by 18 publications

(7 citation statements)

References 38 publications

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“…Bone mineral content increases gradually during childhood and then accelerates during adolescence in both genders, i.e. , the rate of bone formation exceeds the rate of bone resorption, resulting in bone modeling and remodeling [32,33,34,35]. After the cessation of growth, bone mass continues to increase for some years until reaching a peak, which can be defined as the maximum amount of bone mass a person accumulates from birth to skeletal maturity [36,37,38].…”

Section: Adolescence: Anthropometry and Evaluation Of Bone Mineralmentioning

confidence: 99%

Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?

2013

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Obesity and osteoporosis are important global health problems characterized by increasing prevalence with high impact on morbidity and mortality. The objective of this review was to determine whether excess weight during adolescence interferes with bone mass accumulation. If bone mineral gain can be optimized during puberty, adults are less likely to suffer from the devastating complications of osteoporosis. The increased fracture risk in obese children has also been attributed to a lower bone mass for weight compared to non-obese children. Thus, adiposity present in this age group may not result in the protection of bone mass, in contrast to what has been observed in adults. However, studies involving adolescents have reported both protective and detrimental effects of obesity on bone. The results and mechanisms of these interactions are controversial and have not been fully elucidated, a fact highlighting the extreme relevance of this topic and the need to monitor intervening and interactive variables.

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Section: Adolescence: Anthropometry and Evaluation Of Bone Mineralmentioning

confidence: 99%

Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?

2013

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“…The period of puberty is characterized by the occurrence of a fundamental process, i.e., the maximum acquisition of BMC [12, 21–24]. Bone tissue is composed of cells, called osteoblasts and osteoclasts, minerals (calcium and phosphorus), and an organic matrix consisting of collagen and non-collagen proteins.…”

Section: Introductionmentioning

confidence: 99%

“…In this respect, periods of skeletal growth, especially during adolescence, are fundamental for peak bone mass acquisition and to reduce the risk of developing skeletal morbidities such as osteopenia/osteoporosis and fragility fractures in old age [13, 14, 21, 27]. In both genders, peak bone mass acquisition occurs around seven or eight months after maximum longitudinal bone growth (growth spurt) as a result of high concentrations of hormones [22, 24, 25, 28, 29]. …”

Section: Introductionmentioning

confidence: 99%

Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?

Silva

Fiorelli

Silva³

et al. 2017

Nutr Metab (Lond)

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In recent years, there has been growing concern about the occurrence of metabolic syndrome (MetS) at an early age and its effects on bone mass in adolescents. Adolescence is considered a critical period for bone mass gain. Impaired bone acquisition during this phase can lead to “suboptimal” peak bone mass and increase the risk of osteopenia/osteoporosis and fractures in old age. The objective of this review was to perform a critical analysis of articles that specifically focus on this age group, evaluating the influence of MetS and its components on bone mineral density in adolescents. A possible relationship between this syndrome and bone mass has been demonstrated, but the number of studies addressing this topic in adolescents is small. Despite the scarcity of evidence, the results of those studies show that Metabolic Syndrome is negatively correlated with bone mass and also that some components of MetS are negatively correlated with bone mineral density in adolescents. However, the associations between MetS and bone mass development need to be further explored in the age group corresponding to adolescence. Further good-quality studies are necessary to complement the understanding of this relationship.

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“…However, there are no current data in the literature showing that the expected maximum bone mass during adolescence can be reverted when the COC is no longer taken, or the outcomes for COC users as they become elderly people. Thus, the future consequences of the low bone mass acquisition in COC users during the critical period of peak bone mass development remain unknown [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period

et al. 2015

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BackgroundLow-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs.MethodsThis was a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n = 41) taking 20 μg ethinylestradiol/150 μg desogestrel and COC non-user controls (n = 26), were evaluated by bone densitometry examinations at baseline and after 12 months. Comparisons between the groups at the study onset were performed using the Mann–Whitney test with the significance level fixed at 5% or p < 0.05. Comparisons between the groups at the study onset and after 12 months were based on variations in the median percentages for bone mass variables.ResultsThe COC users presented with low bone mass acquisition in the lumbar spine, and had BMD and BMC median variations of 2.07% and +1.57%, respectively, between the measurements at baseline and 12 months. The control group had median variations of +12.16% and +16.84% for BMD and BMC, respectively, over the same period. The total body BMD and BMC showed similar evolutions during the study in both groups. Statistical significance (p < 0.05) was seen for the BMC percentage variation between COC users and non-users.ConclusionsUse of a low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) was associated with lower bone mass acquisition in adolescents during the study period.Trial registrationRegistry Number, RBR-5h9b3c.

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Bone Mineral Density in Healthy Female Adolescents According to Age, Bone Age and Pubertal Breast Stage

Cited by 18 publications

References 38 publications

Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?

Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?

Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?

Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period

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