Bone mineral density in children with steroid-sensitive nephrotic syndrome

Op, Mishra; Meena, Santosh K.; Singh, Santosh Kumar; Prasad, Rajniti; Mishra, Rahul

doi:10.1007/s12098-009-0256-1

Cited by 23 publications

(28 citation statements)

References 9 publications

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“…[7,19,20] However, other studies have reported that cumulative steroid dose does not affect bone density in steroid-sensitive NS patients. [21,22] Similarly, we did not find a statistically significant difference between the cumulative dose of steroid and bone density.…”

Section: Discussioncontrasting

confidence: 54%

The Effects of Steroid Therapy on Bone and Eyes in Children with Nephrotic Syndrome

Yüzüak¹

2017

South Clin Ist Euras

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Section: Discussioncontrasting

confidence: 54%

The Effects of Steroid Therapy on Bone and Eyes in Children with Nephrotic Syndrome

Yüzüak¹

2017

South Clin Ist Euras

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“…The values of E, Z, ∆S and ∆G estimated by Coats-Redfern method are presented in Table 2. The value of ∆S is large and negative and small value of Z suggests that the transition state is in highly ordered state than individual reactant and it is a rate-determining step [27,28]. The kinetic parameters show a somewhat different trend from that of thermal stability.…”

Section: Kinetics Of Decompositionmentioning

confidence: 92%

Synthesis, characterization, biological and electrical conductivity studies of some Schiff base metal complexes

Yaul¹,

Dhande²,

Pethe³

et al. 2014

Bull. Chem. Soc. Eth.

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ABSTRACT. Metal complexes of VO(IV), Zr(IV), Th(IV) and UO2(VI) with Schiff base ligands derived from 4-nitrobenzoylhydrazide with 2-hydroxy-5-methylacetophenone (H2L 1 ) or 2-hydroxy-5-chloroacetophenone (H2L 2 ) have been prepared. All the complexes have been characterized on the basis of elemental analyses, magnetic susceptibility measurement, electronic and IR spectra and thermogravimetric analysis. The IR spectral data suggested that the ligands behave as dibasic tridentate moiety towards the central metal ion coordinating through phenolic oxygen, enolic oxygen and azomethine nitrogen atoms. The elemental analyses show a 1:1 metal:ligand stoichiometry for all the complexes except Th(IV) which has 1:2 stoichiometry. The thermal analysis evidenced that thermal transformations of complexes are processes according to TG curves including dehydration, thermolysis and oxidative degradation of Schiff base. The final product of decomposition is the most stable metallic oxide. The kinetic analysis of the thermogravimetric data was performed by using the Coats-Redfern method. Solid state electrical conductivity of the complexes has been measured in their compressed pellet form over a 310-413 K temperature range. All the complexes show semiconducting behavior as their conductivity increases with increasing temperature and a function of ionic size. All the complexes along with ligands were also screened for their antibacterial and antifungal activities.

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“…They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33]. Ligands having nitrogen donors received considerable attention because of their mixed hard-soft donor character, versatile coordination behavior [34][35] and for their biological activity (i.e., toxicity against bacterial growth [36], anticancer [37] and other biochemical properties [38]). The coordination geometry and nature of donor atoms play key roles in determining the binding extent of complexes to DNA.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

Tak¹

2017

IJRASET

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Novel complexes of copper (II), cobalt (II) and nickel (II) with sulphapyridine and aminothiazole were synthesized and characterized using spectral and analytical techniques. The interaction of cobalt (II) complexes with herring sperm DNA has been performed using absorption titration, viscometric measurements and cyclic voltammetry. The protective activity of metal complexes has been carried out using arose gel electrophoresis. The results indicate that cobalt (II) complex bind to DNA via electrostatic or groove binding with binding constant K b = 4.5 x 10 4 M -1. The antioxidant activity for cobalt (II) complex was also checked. Keywords: hypochromism, peak potential and binding constant. I. INTRODUCTIONThe binding of metal complexes to DNA has been extensively studied over the past decade. Many coordination compounds are able to bind DNA as structural probes[1], DNA foot printing [2], DNA cleaving agents [3][4] and as potential anticancer drugs [5][6]. It is generally believed that many anticancer, antiviral, and antiseptic agents take action through binding DNA [4,[7][8], since the interaction between small molecules and DNA can often cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death [9][10][11]. Many studies indicate that transition metal complexes can bind to DNA via both covalent (replacement of labile coordinating ligand by nitrogen base of DNA (i.e. adenine, Cytosine, guanine, thymine) and or non covalent interaction (intercalation, electrostatic or groove binding) [12]. Many important applications of these complexes require that they can bind via intercalative mode or groove binding [13]. Therefore interaction of complexes especially with planar aromatic heterocyclic ligands, which can insert into the base pairs of DNA duplex has attracted considerable attention [14][15][16]. is an essential element widely distributed in biological system [6,[17][18]. Numerous cobalt complexes has been studied as hydrolytic agent for DNA cleavage [19-20], antitumor, antproli-ferative[21-23], antimicrobial[24-26] and antifungal [21,27], antiviral [28,29], antioxidant [12 ,30] and ant inflammatory activity [30]. They have exhibited antitumorogenic activity by reducing the number and size of carcinogen induced colon tumors and play synergistic role on the activity of certain antitumor drugs, although the mechanism has not been completely clarified [31][32][33]. Ligands having nitrogen donors received considerable attention because of their mixed hard-soft donor character, versatile coordination behavior [34][35] and for their biological activity (i.e., toxicity against bacterial growth [36], anticancer [37] and other biochemical properties [38]). The coordination geometry and nature of donor atoms play key roles in determining the binding extent of complexes to DNA. The importance of central metal ion at the core of the structure is noteworthy [39,40]. Many DNA heterocyclic compounds such as benzothiazole and benzopyra zine derivatives have been evaluated and f...

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Bone mineral density in children with steroid-sensitive nephrotic syndrome

Abstract: Bone mineral density in steroid sensitive nephrotic syndrome is unaffected by cumulative dose of prednisolone therapy both in first episode as well as relapser group of patients.

Cited by 23 publications

References 9 publications

The Effects of Steroid Therapy on Bone and Eyes in Children with Nephrotic Syndrome

The Effects of Steroid Therapy on Bone and Eyes in Children with Nephrotic Syndrome

Synthesis, characterization, biological and electrical conductivity studies of some Schiff base metal complexes

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

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