Bone mineral density correlates with fracture load in experimental side impacts of the pelvis

Beason, David P.; Dakin, Greg J.; López, Robert; Alonso, Jorge E.; Bandak, Faris A.; Eberhardt, Alan W.

doi:10.1016/s0021-9290(02)00330-5

Cited by 59 publications

(42 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the OVX group showed the lowest fracture load as expected. The differences in the fracture load among the groups exhibited a similar pattern to BMD, indicating these results are consistent with an earlier report 39 of a close relationship between BMD and the fracture load. Figure 7 shows the change of distribution of bone matrices observed from a trabecular bone and a cortical bone in the left tibia of ovariectomized rats.…”

Section: Bone Strength and Stiffnesssupporting

confidence: 92%

UltrafineAngelica gigasPowder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect

Choi

Lee

Paik

et al. 2012

Journal of Medicinal Food

View full text Add to dashboard Cite

The root of Angelica gigas (Korean angelica) is traditionally used to treat women's ailments that are caused by an impairment of menstrual blood flow and cycle irregularities. This study evaluated the effect particle size of Korean angelica powder on its efficacy for treating estrogen-related symptoms of menopause. Initially, Korean angelica roots were pulverized into ultrafine powder, and orally administered to the rats at a concentration of 500 mg/kg body weight for 8 weeks. The effects of Korean angelica powder particle size on extraction yield, contents of bioactive compounds (decursin and decursinol angelate), levels of serum ovarian hormones (estradiol and progesterone), reproductive hormones (luteinizing hormone and follicle-stimulating hormone), and experimental osteoporosis parameters (mineral density, strength, and histological features) were determined. A significant increase (fivefold) in the contents of decursin and decursinol angelate in the extract of the ultrafine Korean angelica powder was observed compared to coarse Korean angelica powder. Rats were divided into shamoperated or ovariectomized (OVX) groups that were fed coarse (CRS) or ultrafine (UF) ground Korean angelica root. The serum levels of estradiol in the OVX_UF group were 19.2% and 54.1% higher than that of OVX_CRS group. Serum bonealkaline phosphatase/total-alkaline phosphatase index in the OVX_UF group was half that of the OVX_CRS group. In addition, less trabecular bone loss and thick cortical areas were observed in rats administered ultrafine powder. Therefore, ultrafine grinding may enhance the bioactivity of herbal medicines and be especially useful when their extracted forms lose bioactivity during processing, storage, and oral intake.

show abstract

Section: Bone Strength and Stiffnesssupporting

confidence: 92%

UltrafineAngelica gigasPowder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect

Choi

Lee

Paik

et al. 2012

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…17 Furthermore, Beason et al 3 revealed a positive correlation between pelvic fracture force and total hip BMD using a drop tower to impact the greater trochanter of "isolated" bony pelves (abdominal viscera and surrounding soft tissues removed). Trochanteric soft tissues, on the other hand, have been shown to attenuate forces and increase energy absorption during experimental falls; 23 however, their role in motor vehicle collisions is uncertain.…”

Section: Studymentioning

confidence: 99%

“…12,14 Experimental side impacts using cadavers have produced similar fracture patterns. 3,[8][9][10]29 The severity of pelvic fractures is commonly classified according to the Abbreviated Injury Scale 1 (AIS), where closed pelvic fractures with or without dislocation are scored as AIS = 2; while open, displaced, or comminuted fractures are scored AIS = 3.…”

Section: Introductionmentioning

confidence: 99%

“…Although originally developed as an injury measure for soft tissues, the viscous criterion is "equally applicable to any deformable object" 30 and has been used as a pelvic injury criterion in experimental side impacts. 3,8,29 Both Cavanaugh et al 8 and Viano 29 found the viscous criteria and pelvic compression to be the best predictors of pelvic fracture in their experimental impacts; however, Bouquet et al 5 identified the force to fracture as the best predictor of pelvic tolerance to impact (Table 1). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Trochanteric Soft Tissues and Bone Density on Fracture of the Female Pelvis in Experimental Side Impacts

et al. 2005

View full text Add to dashboard Cite

Pelvic fractures continue to be a source of morbidity and mortality for occupants in motor vehicle side impacts, especially among women. Previous studies have produced fracture tolerances for the female pelvis, yet the roles of soft tissues and bone quality remain unclear. Presently, we studied the influence of trochanteric soft tissue thickness (T) and total hip bone mineral density (BMD) on pelvic fracture of 10 female human pelves subject to lateral impact centered over the greater trochanter. Multiple impacts of increasing severity were performed and impact force, energy, impulse, compression, and viscous criteria were quantified. BMD and T were found to be additive predictors of the fracture force. For a given BMD, the force to fracture was significantly higher than that found previously using isolated pelvic bones. Impulse was found to positively correlate with T; however, maximum compression, viscous criterion, and energy to fracture were independent of BMD and T. The force tolerance at 25% probability of fracture found presently (3.16 kN) is substantially below previously reported values. The results suggest that the trochanteric soft tissue thickness and total hip BMD have a significant bearing on fracture outcome for the female pelvis in automotive side impact.

show abstract

“…For pelvic fracture, 50% risk was defined at 9.6 kN. Beason et al (2003) impacted 12 cadaveric pelves at the greater trochanter using a custom-designed drop mass device. The soft tissues and muscles were removed from the pelves, and 6 pelves were impacted without padding and 6 were impacted with padding.…”

Section: Experimental Investigations Impacting the Pelvis Laterallymentioning

confidence: 99%

A Review of Pelvic Fractures in Adult Pedestrians: Experimental Studies Involving PMHS Used to Determine Injury Criteria for Pedestrian Dummies and Component Test Procedures

Arregui‐Dalmases

Kerrigan

Sánchez-Molina

et al. 2014

Traffic Injury Prevention

View full text Add to dashboard Cite

Bone mineral density correlates with fracture load in experimental side impacts of the pelvis

Cited by 59 publications

References 20 publications

UltrafineAngelica gigasPowder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect

UltrafineAngelica gigasPowder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect

Effects of Trochanteric Soft Tissues and Bone Density on Fracture of the Female Pelvis in Experimental Side Impacts

A Review of Pelvic Fractures in Adult Pedestrians: Experimental Studies Involving PMHS Used to Determine Injury Criteria for Pedestrian Dummies and Component Test Procedures

Contact Info

Product

Resources

About