Bone Mineral Density Changes in Patients with Recent-Onset Rheumatoid Arthritis

Hafez, Eman A.; Mansour, Hoda Anwer; Hamza, Sherin H.; Moftah, Sherine George; Younes, Takwa B.; Ismail, Mohd Nazari

doi:10.4137/cmamd.s7773

Cited by 27 publications

(21 citation statements)

References 24 publications

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“…This is in agreement with another study that has evaluated BMD and disease activity in RA patients as done in Birmingham 1996. Our finding did not match with the study done in Cairo, Egypt 2011 27 which state that BMD changes do occur in patients with early RA, and are not necessarily correlated with disease activity (DAS-28). It is important to mention that disease duration of more than five years is associated with bone loss in particular at FN regardless of treatment.…”

Section: Resultscontrasting

confidence: 99%

Bone mineral density changes in patients with rheumatoid arthritis

Saleh¹,

Media

2017

ZJMS

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Section: Resultscontrasting

confidence: 99%

Bone mineral density changes in patients with rheumatoid arthritis

Saleh¹,

Media

2017

ZJMS

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“…In 30 Egyptian RA patients (aged 35.7 years), osteopenia and osteoporosis were reported in 50% and 13.3%, respectively. [ 11 ] In a Finnish study in premenopausal women with RA ( n = 78), mean LS BMD was 1.157 g/cm 2 , which is slightly higher to that observed in our patients (1.05 g/cm 2 ). [ 12 ] In a Korean study involving 234 RA patients (aged 60 years), osteopenia and osteoporosis were observed in 52% and 39%, respectively.…”

Section: Discussioncontrasting

confidence: 52%

Lean mass and disease activity are the best predictors of bone mineral loss in the premenopausal women with rheumatoid arthritis

Sharma

Dhakad

Wakhlu

et al. 2018

Indian J Endocr Metab

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Background and Objectives:Factors determining bone mineral (BM) loss in rheumatoid arthritis (RA) are not well known. This study aimed to determine the occurrence and predictors of BM loss in the young premenopausal women with RA.Methods:Ninety-six females with RA and 90 matched controls underwent clinical, biochemical, BM density (BMD), and body composition assessments. RA disease activity was assessed using disease activity score-28 (DAS-28) and hand X-ray.Results:In the young premenopausal females with RA having median symptom and treatment duration of 30 (18–60) and 4 (2–12) months, respectively, with moderate disease activity (DAS-28, 4.88 ± 1.17), occurrence of osteoporosis and osteopenia was 7.29% and 25% at spine, 6.25% and 32.29% at hip, and 17.7% and 56.25% at wrist, respectively (significantly higher than controls). RA patients had lower BMD at total femur, lumbar spine (LS), radius total, and radius ultra-distal. Total lean mass (LM) and BM content were significantly lower in RA (P = 0.022 and <0.001, respectively). In RA, BMD at majority of sites (LS, neck of femur, greater trochanter, radius total, and radius 33%) had the strongest positive correlation with LM followed by body fat percent. RA patients with most severe disease had lowest BMD at different sites and lowest LM. Stepwise linear regression revealed LM followed by DAS-28 to be best predictors of BMD. RA patients receiving glucocorticoids did not have significantly different BMDs from patients not taking glucocorticoids.Interpretation and Conclusion:BM loss is a significant problem in the young premenopausal women with recent-onset RA. LM and disease severity were the best predictors of BMD.

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“…Nevertheless, in our study, osteoporosis at all sites was more common in females than in males, without any statistically significant intergroup difference. Furthermore, in the study of Yoon J et al and in similar studies, gender of the patients was significantly associated with osteoporosis (13) . Spine was the most common site of osteoporosis in patients with RA with BMD of 16 %, followed by hip with BMD of 12%.…”

Section: Discussionmentioning

confidence: 72%

Bone Mineral Density in Patients With Early- Onset Rheumatoid Arthritis

Rexhepi¹,

Rexhepi²,

Rexhepi³

et al. 2020

BMJ

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Objective: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease that affects 0.5-1% of the world's population and commonly leads to significant disability and consequent impairment of quality of life. Osteoporosis is an early and common feature in RA and occurs during the course of the disease as extra-articular manifestation of rheumatoid arthritis, which may result in increased risk of fractures, morbidity, and mortality. The aim of this study was to evaluate changes in bone mineral density in patients with early-onset rheumatoid arthritis including its correlation with disease activity. Method: Ther study was performed with 50 patients diagnosied as early-onset rheumatoid made less than two years ago n the Private Clinic "Rheuma", who fulfilled the diagnostic criteria of American College of Rheumatology/ European League Against Rheumatism and 30 healthy volunteers as controls. Bone mineral density of these patients was measured at lumbar spine and hip by using dual energy x-ray absorptiometry scan (DEXA Stratos 800). Demographic and clinical data including age, gender, BMI, menstrual status, disease duration, laboratory tests, and disease activity scale (DAS28) scores were collected. Results: From a total of 50 patients with RA, 36 were females and 14 were males with an overall mean age of 27-57 (33.7±7.87 years), fulfilling ACR/EULAR Criteria. The patients with RA, had osteoporosis (16%), osteopenia (65%) and normal BMD (30%) values. In the group of RA patients with osteoporosis had higher disease activity scores (DAS-28) without any statistically significant correlation compared to RA patients with normal BMD values or osteopenia. Conclusion: Patients with RA are more likely to have bone loss compared to normal age subjects. Lower BMD values were found in patients at earlier stage of the rheumatoid arthritis with higher disease activity. Dual energy x-ray absorptiometry is an important tool to assess BMD in early RA patients.

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Bone Mineral Density Changes in Patients with Recent-Onset Rheumatoid Arthritis

Cited by 27 publications

References 24 publications

Bone mineral density changes in patients with rheumatoid arthritis

Bone mineral density changes in patients with rheumatoid arthritis

Lean mass and disease activity are the best predictors of bone mineral loss in the premenopausal women with rheumatoid arthritis

Bone Mineral Density in Patients With Early- Onset Rheumatoid Arthritis

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