Bone mineral density assessed by dual-energy X-ray absorptiometry in patients with viral or alcoholic compensated cirrhosis. A prospective study

Mahmoudi, Abdelhalim; Sellier, N.; Reboul‐Marty, Jeanne; Chalès, Gérard; Lalatonne, Yoann; Bourcier, Valérie; Grando, Véronique; Barget, Nathalie; Beaugrand, Michel; Trinchet, J.C.; Ganne-Carrié, Nathalie

doi:10.1016/j.clinre.2011.07.009

Cited by 20 publications

(16 citation statements)

References 22 publications

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“…Loss of BMD has been observed in chronic cholestatic disease, alcoholic cirrhosis, viral hepatitis, hemochromatosis and also in liver transplant patients . The prevalence of osteoporosis and osteopenia described in different series of patients with CLD of various etiologies ranges between 11–45% and 18–48%, respectively …”

Section: Introductionmentioning

confidence: 99%

Association between nutritional screening via the Controlling Nutritional Status index and bone mineral density in chronic liver disease of various etiologies

López-Larramona

Lucendo

Tenías³

2014

Hepatology Research

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Section: Introductionmentioning

confidence: 99%

Association between nutritional screening via the Controlling Nutritional Status index and bone mineral density in chronic liver disease of various etiologies

López-Larramona

Lucendo

Tenías³

2014

Hepatology Research

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“…High rates of osteoporosis and bone fracture have been observed in adults with chronic cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), and cirrhosis of any cause. (1)(2)(3) Metabolic bone disease is also common in children with chronic cholestasis or end-stage liver disease, but fewer studies have been conducted to characterize the bone mineral deficits in this vulnerable population.…”

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confidence: 99%

Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis

et al. 2018

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CIC patients had significant bone deficits that persisted after adjustment for height and weight and generally did not correlate with degree of cholestasis. In ALGS, low BMD and BMC reference Z-scores were explained by poor growth. Anthropometrically-adjusted DXA measures in ALGS correlate with markers of cholestasis and fx history. Reduced bone density in this population is multifactorial and related to growth, degree of cholestasis, fracture vulnerability, and contribution of underlying genetic etiology. This article is protected by copyright. All rights reserved.

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“…Osteoporosis and osteopenia are a common complication among cirrhotic patients. Up to 11% of patients with viral or alcoholic compensated Child-Pugh A cirrhosis suffer from osteoporosis at the lumbar spine 3 . As the degree of liver failure and decompensation rises from Child-Pugh A to C, so does the risk of osteoporosis 2,4 .…”

Section: Discussionmentioning

confidence: 99%

Multiple vertebral fractures in a liver transplant recipient with HCV cirrhosis: A case report

Tournis¹

2019

JRPMS

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Cirrhosis is a known major risk factor for osteoporosis. The already compromised bone health of cirrhotic patients tends to deteriorate further after liver transplantation, mainly as a result of immunosuppressive treatment. This case report describes a 63-year-old man who presented with multiple vertebral fractures and severe osteoporosis, one year after orthotopic liver transplantation (OLT) because of end-stage HCV cirrhosis. At his initial consultation, the patient was taking everolimus and mycophenolate, while previously the immunosuppressive regimen included corticosteroids. We present follow-up data of the patient after anti-osteoporotic treatment, including consecutive measurements of bone mineral density, vertebral morphometry, biomarkers of bone turnover and related hormones. Two years after OLT, during which he followed treatment with calcium, vitamin D supplements and zolendronic acid (intravenous infusion of 5mg once a year), the patient showed remarkable improvement in bone densitometry, hormones and biomarkers of bone metabolism, with the exception of persistent secondary hyperparathyroidism. As the survival rates of liver transplant recipients improve, osteoporosis constitutes an important long-term complication among these patients. Consequently, prompt diagnosis and treatment of osteoporosis in cirrhotic and liver transplanted patients is crucial, with biphosphonates, and in particular zolendronic acid, a potent possible first-line therapeutical option.

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Bone mineral density assessed by dual-energy X-ray absorptiometry in patients with viral or alcoholic compensated cirrhosis. A prospective study

Cited by 20 publications

References 22 publications

Association between nutritional screening via the Controlling Nutritional Status index and bone mineral density in chronic liver disease of various etiologies

Association between nutritional screening via the Controlling Nutritional Status index and bone mineral density in chronic liver disease of various etiologies

Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis

Multiple vertebral fractures in a liver transplant recipient with HCV cirrhosis: A case report

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