Bone mineral density and trabecular bone score in Chinese subjects with sarcopenia

Qi, Hanmei; Sheng, Yunlu; Chen, Shu; Siting, Wang; Zhang, Aisen; Cai, Jinmei; Lai, Bin; Ding, Guoxian

doi:10.1007/s40520-019-01266-8

Cited by 21 publications

(17 citation statements)

References 22 publications

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“…In this study, TLM was significantly associated with bone quantity and quality in both males and females. Participants with poor bone quantity and quality were more likely to have less TLM; similar results were found in previous studies [ 25 , 26 ]. Locquet et al reported that a decline in the skeletal muscle mass index was associated with a lower spine BMD (OR = 2.12), hip BMD (2.42), and TBS (3.99) [ 25 ].…”

Section: Discussionsupporting

confidence: 89%

Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults

Lin

Juan

Chan

et al. 2021

JCM

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Background: The utility of muscle health for predicting asymptomatic vertebral fracture (VF) is uncertain. We aimed to determine the effects of muscle health on bone quantity and quality in the older adults and to integrate these factors into a predictive model for VF. Methods: We prospectively recruited participants with a body mass index <37 kg/m2. The total lean mass (TLM), appendicular skeletal muscle index, presence of sarcopenia, and bone mineral density were determined by dual-energy X-ray absorptiometry, and bone quality by the trabecular bone score (TBS). VF was diagnosed based on spine radiography. Results: A total of 414 females and 186 males were included; 257 participants had VF. Lower TLM was significantly associated with poorer bone quantity and quality in both males and females. A low TBS (OR: 11.302, p = 0.028) and sarcopenia (Odds ratio (OR): 2.820, p = 0.002) were significant predictors of VF in males, but not bone quantity. Moreover, integrating TBS and sarcopenia into the predictive model improved its performance. Conclusions: Although TLM was associated with bone quantity and quality in both sexes, sarcopenia and a low TBS were significant predictors of asymptomatic VF only in male participants.

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Section: Discussionsupporting

confidence: 89%

Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults

Lin

Juan

Chan

et al. 2021

JCM

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“…In contrast, muscle strength assessed by grip strength but not by muscle mass was related to bone status in an elderly cohort of Chinese men and women with higher grip strength being associated with a lower risk of osteoporosis [26]. Similar to our findings, Qi et al found that muscle strength (grip strength) was positively associated with hip and spine aBMD in women (40-90 years) but not in their male counterparts [27]. However, they did find that muscle mass (relative appendicular skeletal muscle mass) was positively associated with aBMD in both sexes.…”

Section: Discussionsupporting

confidence: 87%

Muscle-Bone Interactions in Chinese Men and Women Aged 18–35 Years

Chen

Baker

et al. 2020

Journal of Osteoporosis

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To characterize bone mineral density (BMD), bone strength, muscle and fat mass, and muscle strength and power in Chinese women (n = 25) and men (n = 28) classified as in the bone accrual phase (18–25 years) or in the peak bone mass phase (26–35 years). Calcium intakes, physical activity levels, and serum vitamin D were measured. Dual-energy X-ray absorptiometry (DXA) assessed body composition, lumbar spine, and hip areal BMD (aBMD) variables and peripheral quantitative computed tomography (pQCT) assessed cortical and trabecular volumetric BMD (vBMD) and bone strength. Muscle strength and power were assessed by grip strength, leg press, and vertical jump tests. Calcium, serum vitamin D, and physical activity levels were similar across age and sex groups. Significant sex differences p<0.05 were found for most body composition variables, hip aBMD, tibia variables, and muscle strength and power. Adjusting for height and weight eliminated most of the significant sex differences. Women showed stronger positive correlations between body composition and bone variables (r = 0.44 to 0.78) than men. Also, correlations between muscle strength/power were stronger in women vs. men (r = 0.43 to 0.82). Bone traits were better related to body composition and muscle function in Chinese women compared to Chinese men aged 18 to 35 years, and peak bone mass seems to be achieved by 25 years of age in both Chinese men and women since there were no differences between the two age groups.

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“…In older Chinese adults, higher handgrip strength was associated with lower risk of osteoporosis [27]. Although, in older Chinese women with osteoporosis, handgrip strength was correlated with femoral neck, hip and lumbar spine BMD, in the same study such correlations were not found in men's group [30]. As mentioned earlier, handgrip strength was also associated with lean mass, appendicular lean mass, arm and leg lean mass and SMMI.…”

Section: Discussionmentioning

confidence: 59%

Associations Between Muscle Mass, Muscle Morphology and Bone Health in Older Men With Sarcopenia: A Cross-sectional Study

Mastavičiūtė

Kilaite²,

Petroška³

et al. 2020

Preprint

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Background: The aim of this study was to explore the association between muscle mass, morphology, bone mineral density, and physical function in community-dwelling older men with sarcopenia.Methods: A total of 151 men, 60 years or older were included in this study. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Low bone mineral density was diagnosed if T-score was equal to or below -1.0 SD of mean young men reference range. Sarcopenia was diagnosed according to European Working Group on Sarcopenia in Older People (EWGSOP) criteria: low muscle mass and low muscle strength or low physical performance. Physical performance was evaluated by short physical performance battery. Microbiopsy of musculus vastus lateralis was performed with disposable muscle microbiopsy system. The perimeter and cross-section area of muscle fibers were calculated using image analysis software in whole slide images; type of fiber and their distribution were evaluated as well. Relationship between variables were examined using Spearman’s and Pearson’s correlations. The level of significance (p-value) of < 0.05 was considered as statistically significant.Results: Mean age of the subjects was 72.9 ± 8.02 years. Sarcopenia was diagnosed in 45 (29.8%) men. In the sarcopenia group, 25 muscle biopsies were examined. The average muscle fiber length was 217.47 ± 25.22 microm and average fiber cross-sectional area was 2446 ± 608.87 microm2. In 9 sarcopenic men with T-scores equal or below -2.5, the muscle fiber area had a significant correlation with balance test (r = 0.73, p = 0.025). Multiple significant correlations were found between bone mineral density, lean mass, appendicular lean mass, arm and leg lean mass, gait speed, balance test and handgrip strength.Conclusions: In men with sarcopenia, low lean muscle mass was associated with low femoral neck and hip BMD, and lower muscle strength. In sarcopenic men with osteoporosis, lower muscle fiber area was associated with lower scores of balance test.Trial registration: study protocol has been approved by Lithuanian regional biomedical research ethics committee (No. 158200-03-208-75).

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Bone mineral density and trabecular bone score in Chinese subjects with sarcopenia

Cited by 21 publications

References 22 publications

Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults

Integrating Muscle Health in Predicting the Risk of Asymptomatic Vertebral Fracture in Older Adults

Muscle-Bone Interactions in Chinese Men and Women Aged 18–35 Years

Associations Between Muscle Mass, Muscle Morphology and Bone Health in Older Men With Sarcopenia: A Cross-sectional Study

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