Bone mineral density and risk factors for osteoporosis—A population-based study of 1600 perimenopausal women

Kröger, Heikki; Tuppurainen, Marjo; Honkanen, Risto; Alhava, Esko; Saarikoski, Seppo

doi:10.1007/bf00310160

Cited by 202 publications

(136 citation statements)

References 42 publications

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“…The mean BMD at the lumbar spine was increased at follow-up (1?097 g/cm 3 ) compared with baseline (1?087 g/cm 3 ). About half of the women (54?5 %) currently used or had used HT at some time in their life.…”

Section: Resultsmentioning

confidence: 94%

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Alcohol consumption and bone mineral density in elderly women

Sommer

Erkkilä

Järvinen

et al. 2012

Public Health Nutr.

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Objective: Findings regarding alcohol consumption and bone mineral density (BMD) in elderly women have been inconsistent. The objective of the present study was to explore the association of alcohol intake with BMD in elderly women. Design: This cohort study included women from the population-based Kuopio Osteoporosis Risk Factor and Prevention -Fracture Prevention Study (OSTPRE-FPS). Alcohol intake and potential confounders were assessed at baseline and after 3 years of follow-up using a lifestyle questionnaire. In addition, an FFQ was distributed in the third year to measure dietary intake, including alcohol. Women underwent BMD measurements at the femoral neck and lumbar spine at baseline and after 3 years of follow-up. Setting: Kuopio Province, Finland. Subjects: Three hundred elderly women (mean age 67?8 years) who provided both BMD measurements and FFQ data. Results: Alcohol consumption estimated from the FFQ and lifestyle questionnaire was significantly associated with BMD at both measurement sites after adjustment for potential confounders, including lifestyle and dietary factors (P , 0?05). Using the FFQ, women drinking .3 alcoholic drinks/week had significantly higher BMD than abstainers, 12?0 % at the femoral neck and 9?2 % at the lumbar spine. Results based on the lifestyle questionnaire showed higher BMD values for all alcohol-consuming women at the femoral neck and for women drinking 1-3 alcoholic beverages/week at the lumbar spine, compared with non-users. Conclusions:The results from OSTPRE-FPS suggest that low to moderate alcohol intake may exert protective effects on bone health in elderly women.

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Section: Resultsmentioning

confidence: 94%

“…Among a group of peri-and postmenopausal women, alcohol consumption (mean intake of consumers was 125 g/week) was a positive predictor for spine BMD (3) . The women participating in the present study consumed at most 1-3 drinks/week or .3 drinks/week, respectively, which corresponds to weekly alcohol intake of 10-30 g or more.…”

Section: Discussionmentioning

confidence: 97%

Alcohol consumption and bone mineral density in elderly women

Sommer

Erkkilä

Järvinen

et al. 2012

Public Health Nutr.

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“…While excessive alcohol intake negatively affects BMD (28), moderate alcohol consumption seems to have a positive effect (21,29,30). Other studies, however, have failed to find such an effect for smoking and alcohol (18,21,(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Osteoporosis in the Thrace Region of Turkey: A Community-Based Study

Keskin¹,

Cekin²,

Gündüz³

et al. 2014

Turk J Phys Med Rehab

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Objective: This study was planned as a community-based research study to estimate the prevalence of osteoporosis and explore related risk factors in the Thrace region of Turkey. Material and Methods:The community-based study involved a total of 620 people, 498 women and 122 men, aged between 40 and 89 years. A questionnaire on the medical history and lifestyles of the participants was applied with a face-to-face interview. Body weight height, and arm span of each participant were measured, together with bone mineral density at the middle phalanges of the second, third, and fourth digits of the non-dominant hand using dual-energy X-ray laser absorptiometry. Results: Age, clothing, lack of regular exercise, and giving birth to more than two children seem to contribute to osteoporosis, while high education, high economic level, tea and moderate alcohol consumption, oral contraceptive use, and hormone replacement therapy seem to retard osteoporosis. Osteoporotic patients had more fractures in the past. Height and weight were significantly lower in osteoporotic women. Conclusion: Lifestyle affects the prevalence of osteoporosis. Drinking tea and alcohol seems to be controversial with regard to osteoporosis risk. Key Words: Osteoporosis, bone density, risk factors, lifestyle Özet Amaç: Çalışma, Türkiye'nin Trakya bölgesinde osteoporoz prevalansını kestirmek ve ilgili risk faktörlerini ortaya çıkarmak amacıyla tasarlandı. Gereç ve Yöntemler: Toplum temelli çalışma, yaşları 40 ile 89 arasında, 498 kadın ve 122 erkekten oluşan toplam 620 kişiyi kapsadı. Çalışmaya katılanların tıbbi geçmişlerini ve yaşam tarzlarını sorgulayan bir anket yüz yüze gerçekleştirildi. Kilo, boy, kulaç uzunluğu ve Dual-Enerji X-ray lazer absorpsiyometri ile baskın olmayan elin 2, 3 ve 4.parmaklarının orta falankslarından kemik mineral yoğunluğu ölçüldü. Bulgular: Yaş, giyinme, düzenli egzersiz yokluğu ve doğum sayısı osteoporoz ihtimalini arttırıyor görünürken iyi eğitimli olma, ekonomik seviyenin yüksekliği, çay ve hafif alkol tüketimi, doğum kontrol hapı kullanımı ve hormon replasman tedavisi osteoporozu yavaşlatıyor görünmektedir. Osteoporotik hastaların geçmişlerinde daha fazla kırık tespit edilmiştir. Osteoporotik kadınların boyu ve kilosu belirgin biçimde daha az bulunmuştur. Sonuç: Yaşam stili osteoporoz prevalansını etkilemektedir. Çay ve alkol içmenin osteoporoz riski açısından etkisi tartışmalı görünmektedir.

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“…Two related normally distributed groups were compared using the paired t-test. Since age and BMI are known risk factors for low BMD [29,30], general linear modelling was used to compare BMD between type 1 and type 2 diabetes after adjusting for these variables. Likewise, after adjusting for age and BMI, the effect of diabetic status on BMD was examined using a Generalised Estimating Equations procedure that recognised matching.…”

Section: Discussionmentioning

confidence: 99%

Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

et al. 2006

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Aims/hypothesis: We assessed the effects of type 1 and type 2 diabetes on bone density and metabolism.Materials and methods: We analysed bone mineral density (BMD) measured at the hip, spine and forearm using dual energy X-ray absorptiometry in 34 patients with type 1 and 194 patients with type 2 diabetes. Patients were from the community-based Fremantle Diabetes Study, and findings for them were compared with those from normal age-and sex-matched control subjects from the local community. Biochemical and hormonal markers of bone metabolism were measured in a subset of 70 patients. Results: After adjusting for age and BMI, there was a lower BMD at total hip (p<0.001) and femoral neck (p=0.012) in type 1 men vs control subjects, but type 1 women and matched controls had similar BMD at each site. There was a higher BMD at total hip (p=0.006), femoral neck (p=0.026) and forearm (p<0.001) in type 2 women vs control subjects, but diabetes status was not associated with BMD in type 2 men after adjustment for age and BMI. Serum oestradiol, BMI, C-terminal telopeptide of collagen type 1 and male sex were consistently and independently associated with BMD at forearm, hip and femoral neck and explained 61, 55 and 50% of the total variance in BMD, respectively, at these sites. Spine BMD was independently associated with BMI and ln(oestradiol). Conclusions/interpretation: Men with type 1 diabetes may be at increased risk of osteoporosis, while type 2 women appear to be protected even after adjusting for BMI. Low serum oestradiol concentrations may predispose to diabetes-associated osteoporosis regardless of sex.

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Bone mineral density and risk factors for osteoporosis—A population-based study of 1600 perimenopausal women

Cited by 202 publications

References 42 publications

Alcohol consumption and bone mineral density in elderly women

Alcohol consumption and bone mineral density in elderly women

The Prevalence of Osteoporosis in the Thrace Region of Turkey: A Community-Based Study

Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

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