Bone mineral density and osteoporosis in relation to all-cause and cause-specific mortality in NHANES: A population-based cohort study

Cai, Shengguan; Fan, Jiaqi; Zhu, Lina; Ye, Jianhong; Rao, Xianming; Fan, Chunhong; Zhong, Yaohong; Li, Yingjun

doi:10.1016/j.bone.2020.115597

Cited by 40 publications

(29 citation statements)

References 38 publications

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“…NHANES, as a major program of the National Center for Health Statistics (NCHS), aims to evaluate the health and nutrition of adults and children in the United States ( 12 , 13 ). The survey adopts a complex multistage sampling method every year to extract nationally representative data of ~5,000 people ( 14 ). The data collection process in NHANES contained two parts, an in-person interview (including demographic, socioeconomic, dietary, and health-related questions) and a physical examination (including medical, dental, and physiological measurements, as well as laboratory tests) performed in the Mobile Examination Center (MEC) ( 14 , 15 ).…”

Section: Methodsmentioning

confidence: 99%

“…The survey adopts a complex multistage sampling method every year to extract nationally representative data of ~5,000 people ( 14 ). The data collection process in NHANES contained two parts, an in-person interview (including demographic, socioeconomic, dietary, and health-related questions) and a physical examination (including medical, dental, and physiological measurements, as well as laboratory tests) performed in the Mobile Examination Center (MEC) ( 14 , 15 ). https://www.cdc.gov/nchs/nhanes/about_nhanes.htm .…”

Section: Methodsmentioning

confidence: 99%

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Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

et al. 2022

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AimThe aim of this study was to assess the relationship of circadian syndrome and stroke.MethodsWe performed a cross-sectional analysis of 11,855 participants from the National Health and Nutrition Examination Survey (NHANES) database between 2005 and 2018, and collected the baseline characteristics. Multivariate logistic regression models were developed to explore the association between circadian syndrome and stroke. Simultaneously, subgroup analyses based on the difference of gender, race, and components associated with circadian syndrome also were performed. The odds ratio (OR) and 95% CI were calculated in this study.ResultsAll the participants were divided into the non-stroke group and the stroke group. There were approximately 3.48% patients exclusively with stroke and 19.03% patients exclusively with circadian syndrome in our study. The results suggested that the risk of stroke in patients with circadian syndrome was higher than that in patients without circadian syndrome (OR = 1.322, 95 CI%: 1.020–1.713). Similar associations were found in women with circadian syndrome (OR = 1.515, 95 CI%: 1.086–2.114), non-Hispanic whites with circadian syndrome (OR = 1.544, 95 CI%: 1.124–2.122), participants with circadian syndrome who had elevated waist circumference (OR = 1.395, 95 CI%: 1.070–1.819) or short sleep (OR = 1.763, 95 CI%: 1.033–3.009).ConclusionCircadian syndrome was associated with the risk of stroke. Particularly, we should pay more close attention to the risk of stroke in those populations who were female, non-Hispanic whites, had the symptoms of elevated waist circumference or short sleep.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

et al. 2022

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“…Importantly, by using the NHANES data, we have further extended such associations between NoT and mortality in the context of the US community-dwelling population, after accounting for the baseline systemic comorbidities. The motivation to consider femoral neck BMD as a risk factor for all-cause mortality was based on a recent report [32], which similarly conducted analysis based on the NHANES data. Cai and colleagues identified that femoral neck BMD was predictive of the all-cause mortality after controlling for correlated risk factors.…”

Section: Discussionmentioning

confidence: 99%

Number of teeth is associated with all-cause and disease-specific mortality

Cheung

Steffensen

et al. 2021

BMC Oral Health

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Background Tooth loss has been shown to correlate with multiple systemic comorbidities. However, the associations between the number of remaining natural teeth (NoT) and all-cause mortality have not been explored extensively. We aimed to investigate whether having fewer NoT imposes a higher risk in mortality. We tested such hypotheses using three groups of NoT (20–28,10–19, and 0–9), edentulism and without functional dentition (NoT < 19). Methods The National Health and Nutrition Examination Survey in the United States (NHANES) (1999–2014) conducted dental examinations and provided linkage of mortality data. NHANES participants aged 20 years and older, without missing information of dental examination, age, gender, race, education, income, body-mass-index, smoking, physical activities, and existing systemic conditions [hypertension, total cardiovascular disease, diabetes, and stroke (N = 33,071; death = 3978), or with femoral neck bone mineral density measurement (N = 13,131; death = 1091)] were analyzed. Cox proportional hazard survival analyses were used to investigate risks of all-cause, heart disease, diabetes and cancer mortality associated with NoT in 3 groups, edentulism, or without functional dentition. Results Participants having fewer number of teeth had higher all-cause and disease-specific mortality. In fully-adjusted models, participants with NoT0-9 had the highest hazard ratio (HR) for all-cause mortality [HR(95%CI) = 1.46(1.25–1.71); p < .001], mortality from heart diseases [HR(95%CI) = 1.92(1.33–2.77); p < .001], from diabetes [HR(95%CI) = 1.67(1.05–2.66); p = 0.03], or cancer-related mortality [HR(95%CI) = 1.80(1.34–2.43); p < .001]. Risks for all-cause mortality were also higher among the edentulous [HR(95%CI) = 1.35(1.17–1.57); p < .001] or those without functional dentition [HR(95%CI) = 1.34(1.17–1.55); p < .001]. Conclusions Having fewer NoT were associated with higher risks for all-cause mortality. More research is needed to explore possible biological implications and validate our findings.

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“…Data on 21,939 participants were available for analysis of the total femur, femur neck, and trochanter and intertrochanter of the femur, and 18,116 participants were available for analysis of the lumbar spine. The detailed description of the NHANES was published elsewhere (6,19). All authors declared that all methods in this study were carried out in accordance with relevant guidelines and regulations.…”

Section: Study Populationmentioning

confidence: 99%

“…Approximately 10.2 million people aged 50 years and over had osteoporosis in 2010 in the US, and the number is expected to reach 13.5 million by 2030 (1,2). Osteoporosis, characterized by reduced bone mass, low bone mineral density (BMD), and bone microstructure deterioration (3,4), increases the risk of all-cause mortality, including cardiovascular-and cancer-related mortality (5)(6)(7). The etiology of reduced bone mass and the development of osteoporosis is related to multiple factors, including genetic, environmental, and dietary factors (8,9).…”

Section: Introductionmentioning

confidence: 99%

Association between dietary selenium intake and bone mineral density in the US general population

Xue¹,

Liu²

2022

Ann Transl Med

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Background: Osteoporosis, characterized by reduced bone mineral density (BMD) increases the risk of allcause mortality. Assessments of whether dietary selenium intake is related to bone health are scarce, with few relevant studies limited by a small sample size. The aim of the present study was to investigate the association between dietary selenium intake and BMD levels in the National Health and Nutrition Examination Survey (NHANES) database. Methods:We extracted and aggregated data from 4 cycles of the NHANES [2005][2006][2007][2008][2009][2010][2013][2014].Dietary selenium intake was obtained from 24-hour dietary recall interviews. BMD measurement, including the femur, femur neck, trochanter and intertrochanter of the femur, and lumbar spine, was performed using dual-energy X-ray absorptiometry. The multivariable linear regression model for the association between dietary selenium intake and BMD and the generalized additive model (GAM) for the dose-response relationship were used.Results: A total of 21,939 participants were included. The mean age was 40.68±22.42 years, and 51.28% were male. In the multivariable adjustment model, participants with the highest quintiles of dietary selenium intake (Q5) were associated with increased BMD levels in the total femur (β=0.

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Bone mineral density and osteoporosis in relation to all-cause and cause-specific mortality in NHANES: A population-based cohort study

Cited by 40 publications

References 38 publications

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

Number of teeth is associated with all-cause and disease-specific mortality

Association between dietary selenium intake and bone mineral density in the US general population

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