Bone Mineral Density and Importance of a Gluten-Free Diet in Patients With Celiac Disease in Childhood

Kalaycı, Ayhan Gazi; Kansu, Aydan; Girgin, Nurten; Küçük, Ömer; Araş, Gülseren

doi:10.1542/peds.108.5.e89

Cited by 111 publications

(102 citation statements)

References 23 publications

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“…Osteopenia/osteoporosis is present at diagnosis of CD in all ages and in patients who fail to adhere to the gluten-free diet. 15,16 Treatment with gluten-free diet reduces or normalises the osteopenia. 17 A special form of epilepsy with occipital calcifications is also linked to CD.…”

Section: Box 1 Difficulties In Complex Inheritancementioning

confidence: 99%

Searching for genes influencing a complex disease: the case of coeliac disease

et al. 2007

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Recently, a few genes have been reported to be causative in inflammatory diseases. Still, we are waiting for the vast majority to be discovered. New tools for genotyping and statistical analysis have been developed and emphasis has been put on study design. Coeliac disease (CD) is a disorder, where prolamins in dietary wheat gluten and related proteins from rye or barley are not tolerated. It is one of the most common chronic diseases in humans exceeding a population prevalence of 1%. In this article, we will summarise what is currently known about the genetics influencing CD with the emphasis on the non-HLA genetic component. We will discuss some difficulties when searching for susceptibility genes in disorders with complex inheritance patterns.

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Section: Box 1 Difficulties In Complex Inheritancementioning

confidence: 99%

Searching for genes influencing a complex disease: the case of coeliac disease

et al. 2007

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“…It can be prevented by adherence to a glutenfree diet and is reversed in children and young adults within one year of diagnosis through dietary compliance (49)(50)(51). Whether asymptomatic individuals detected by screening will have the same incidence of osteopenia and osteoporosis is not yet established.…”

Section: Osteoporosismentioning

confidence: 99%

Practical considerations for the identification and follow-up of children with celiac disease

Dirks

2004

Paediatrics &Amp; Child Health

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Celiac disease is an immune-mediated enteropathy affecting 0.5% to 1% of children and is induced by dietary gluten in susceptible individuals carrying the human leukocyte antigen DQ2 or DQ8 heterodimer. If serological screening is positive or if a patient displays suggestive symptoms, an endoscopic biopsy of the distal duodenum is required to confirm the diagnosis. Symptoms of celiac disease are often mild or absent. Overt malabsorption occurs in only 2% to 10% of children. Individuals with a higher risk of developing celiac disease, including first-degree relatives of affected patients and children with type I diabetes, Turner syndrome, Williams syndrome or Down syndrome, should be offered screening for celiac disease along with a discussion of the implications. If serological testing is negative, a high index of suspicion should remain if malabsorption, iron deficiency or osteopenia is present. Also, immunoglobulin A deficiency should be excluded. At-risk individuals should undergo serial serological screening. Lifelong adherence to a gluten-free diet is the only treatment. If left untreated, symptomatic children with celiac disease carry an increased risk of developing osteoporosis and have a greater lifetime risk of cancer. The long-term outcome of undiagnosed or untreated asymptomatic individuals is less clear.Key Words: Celiac disease; Gluten-free diet; Gluten-sensitive enteropathy; IgA deficiency; Tissue transglutaminase; Type I diabetes Des considérations pratiques pour dépister et suivre les enfants atteints d'une maladie coeliaqueLa maladie coeliaque est une entéropathie d'origine immunologique qui touche de 0,5 % à 1,0 % des enfants et qui est induite par le gluten diététique chez des individus susceptibles porteurs de l'antigène HLA DQ2 ou DQ8 hétérodimère. Si le dépistage sérologique est positif ou si un patient présente des symptômes évocateurs, une biopsie endoscopique du duodénum distal s'impose pour confirmer le diagnostic. Les symptômes de maladie coeliaque sont souvent légers ou inexistants. Une malabsorption patente ne s'observe que chez 2 % à 10 % des enfants. Les individus plus vulnérables à la maladie coeliaque, y compris les parents au premier degré des patients atteints et les enfants souffrant

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“…There is a debate in the literature about whether the gluten-free diet (GFD) may help in the restoration of bone mass; while some authors have found benefit (6)(7)(8), others deny it (9,10). A third group found out that bone mineral density values normalize only in children that follow a strict GFD (11).…”

Section: Introductionmentioning

confidence: 99%

Impact of a gluten-free diet on bone mineral density in celiac patients

Kotze¹,

Skare²,

Vinholi³

et al. 2015

Rev Esp Enferm Dig

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Background: Osteoporosis (OP) is a metabolic bone illness that may complicate celiac disease (CD). It can lead to devastating consequences because of low bone mass and fragility fractures.Purpose: To study the OP prevalence in a group of Brazilian patients with CD and the value of a gluten free diet (GFD).Methods: Retrospective study of celiac female patients from a single University Center followed with bone densitometries. Results from densitometry made at first visit were compared with a second study after a median time of 5 years. During this period, patients were submitted to a GFD according to orientations from special program training. Calcium and vitamin D were prescribed to those patients who did not reach the minimal daily requirement through diet.Results: Forty-one celiac female patients, mean age 46.1 ± 14.8 years, were included. The prevalence of osteopenia at first visit was 56.1% and that of osteoporosis 29.2%. Osteoporosis was associated with longer disease duration (p = 0.01). The second densitometry was performed in a median time of 5 years (range 1 to 13 years) and disclosed 58.9% osteopenia and 28.2% osteoporosis. The GFD improved bone mass, mainly at (of) spine (comparison of T score with p = 0.03 and of bone mass in g/cm

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Bone Mineral Density and Importance of a Gluten-Free Diet in Patients With Celiac Disease in Childhood

Cited by 111 publications

References 23 publications

Searching for genes influencing a complex disease: the case of coeliac disease

Searching for genes influencing a complex disease: the case of coeliac disease

Practical considerations for the identification and follow-up of children with celiac disease

Impact of a gluten-free diet on bone mineral density in celiac patients

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