Bone mineral density and bone turnover markers in women with connective tissue dysplasia

Smetanin, M. Yu.; Nurgalieva, S. Yu.; Kononova, Natalia; Пименов, Л. Т.; Чернышова, Т Е

doi:10.32000/2072-1757-2019-4-102-106

Cited by 4 publications

(2 citation statements)

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“…«Рецепт», 2024, том 27, № 1 Со временем происходит уменьшение синтеза коллагена типа I, а коллагеновые волокна фрагментируются и истончаются [16,17].…”

Section: резюме _____________________________________________________...unclassified

The Role of Oral Forms of Collagen in Cosmetology Practice

Шилова,

Левончук,

Панкратов

2024

Рецепт

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Коллаген – основной структурный компонент дермы. Основное вещество соединительной ткани представлено во всех органах в виде стромы, перемычек между тканями, волокнах дермы. Заболевание, при котором наблюдается дефицит коллагена с правильной пространственной организацией волокон и/или избыток дефектного фрагментированного коллагена, называется дисплазией соединительной ткани. Основными клиническими признаками недифференцированной дисплазии соединительной ткани у пациентов косметологического профиля являются ранние инволюционные изменения кожи, положительная щипковая проба и кожная гиперрастяжимость. Высокая распространенность таких пациентов в практике косметологов и дерматологов привела к созданию скрининговой анкеты по выявлению и протоколов коррекции недифференцированной дисплазии соединительной ткани. При наличии признаков недифференцированной дисплазии соединительной ткани у пациента следует минимизировать агрессивность процедур, назначить аминокислотную заместительную терапию и препараты пищевого коллагена в качестве дополнительной поддержки синтеза коллагена. Collagen is the main structural component of the dermis. The main substance of connective tissue is represented in all organs in the form of stroma, bridges between tissues, and fibers of the dermis. A disease in which there is a deficiency of collagen with the correct spatial organization of fibers and/or an excess of defective fragmented collagen is called connective tissue dysplasia. The main clinical signs of undifferentiated connective tissue dysplasia in cosmetology patients are early involutional skin changes, a positive pinch test and skin hyperextension. The high prevalence of such patients in the practice of cosmetologists and dermatologists has led to the creation of a screening questionnaire for the identification and correction protocols of undifferentiated connective tissue dysplasia. If there are signs of undifferentiated connective tissue dysplasia in the patient, the aggressiveness of the procedures should be minimized, amino acid replacement therapy and dietary collagen preparations should be prescribed as additional support for collagen synthesis.

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Section: резюме _____________________________________________________...unclassified

The Role of Oral Forms of Collagen in Cosmetology Practice

Шилова,

Левончук,

Панкратов

2024

Рецепт

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“…One of the key patterns of osteoarthrosis progressing is the disorder of metabolic processes in articular connective tissue and, in particular, the disorder of collagen synthesis and disorganization of the spatial orientation of collagen molecules, pyridinoline (PYD) being the integral indicator of this disorganization. The functional value of PYD is to ensure the stability of cross-links in collagen fibers and elastin forming from hydroxylysyl and lysyl residues and catalyzed by lysyl oxidase [2]. PYD was first isolated from bovine achilles tendon and described by D. Fujimotto, et al (1977) [3], it is comprised in collagen fibers of bone and cartilage tissues while never found in skin collagen [4].…”

Section: Relevancementioning

confidence: 99%

Pyridinoline in Evaluation of Subchondral Remodeling and Cartilaginous Tissue Metabolism in Patients With Early Signs of Knee Osteoarthrosis

Белова

Гладкова

Zubavlenko

et al. 2022

Preprint

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Osteoarthrosis is a polyetiological disease affecting 15 to 85 percent of people over 40 years of age. It makes as much as 50 percent of all articular pathology cases, so the interest of the scientific community in this problem keeps growing. One of the key patterns of osteoarthrosis progressing is the disorder of metabolic processes in articular connective tissue and, in particular, the disorder of collagen synthesis and disorganization of the spatial orientation of collagen molecules. Pyridinoline (PYD) is the integral indicator of this disorganization; it ensures the stability of collagen matrix due to the formation of pyridine crosslinks. Some research claim the predictive value of PYD determining in patients with rheumatoid arthritis and other connective tissue pathologies in joints. Our study involved 42 patients aged 36-50 years with early signs of knee osteoarthrosis and 19 virtually healthy individuals without articular pathologies. All patients underwent standard radiography of their knee joints in the anterior (maximally extended position of the knee joint) and lateral (joint flexion up to 15º) projections in the supine position. Bone formation was assessed by osteocalcin (OC) content and bone resorption by CrossLaps and PYD levels while cartilage matrix destruction by cartilage oligomeric matrix protein (COMP) and cartilage glycoprotein (YKL-40) serum concentrations with enzyme immunoassay (ELISA) method. Our findings showed that the disorders of bone formation (increased OC level) and bone resorption (increased CrossLaps and PYD levels) as well as the rearrangement of the cartilage matrix structure featured by the increased COMP and YKL-40 contents were specific for patients with early signs of knee osteoarthrosis lacking evident clinical and radiological manifestations of the disease. Interestingly, the significant (p<0.05) increase in pyridinoline serum concentration possibly resulted from the intermolecular disbanding in collagen polypeptide chains as a structure-forming component of the extracellular matrix in connective tissue. The sensitivity and specificity assessment of changes in PYD serum concentrations reneders the use of this indicator in the comprehensive evaluation of the condition of patients with early signs of knee osteoarthrosis aimed at increasing the effectiveness of diagnostic approaches to early osteoarthrosis detection and the designning pathogenetic therapy to be a promising trend for further research.

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Protocols on correction of signs of undifferentiated connective tissue dysplasia using hardware and injection techniques in cosmetic patients

Svechnikova¹,

Morzhanaeva

Gorskaya³

et al. 2023

Medicinskij sovet

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Undifferentiated connective tissue dysplasia (UCTD) is a genetically determined condition with a progressive course characterized by defects in the fibrous structures and the basic connective tissue substance, leading to impaired formation of organs and systems, which determines the features of the associated pathology, as well as the pharmacokinetics and pharmacodynamics of drugs. In dermatological and cosmetological practice, the issue of UCTD is very topical, as individual external presentations of the connective tissue dysmorphogenesis among young people can reach 85.4%. In recent decades, a real revolution has taken place in aesthetic medicine, which is associated with the emergence of new injectable products, development of hardware, cellular and thread techniques. Every year mew methods of treatment emerge and the existing ones are improved. Statistics of the past years show that minimally invasive non-surgical interventions are becoming more and more popular in all countries, their number significantly exceeds the number of surgical operations. To date, there are 2 groups of methods aimed at collagen stimulation: hardware techniques and injection methods. The effectiveness of the use of polylactic acid drugs as the first-line drugs for the correction of UCTD in order to prevent premature ageing was evaluated in the presented clinical cases. Patients with a cosmetology profile were treated according to the complex protocols that included amino acid replacement therapy, IV therapy, contour correction with drugs containing polylactic acid and hardware techniques (microneedle RF lifting with insulated and non-insulated needles, ultrasonic SMAS lifting, ablative laser techniques, Ipl-therapy). As a result, an algorithm for managing a patient with UCTD was developed in the cosmetology practice. The provided clinical cases show that the detection of signs of UCTD can significantly improve the patient’s quality of life and prevent premature aging.

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Bone mineral density and bone turnover markers in women with connective tissue dysplasia

Cited by 4 publications

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The Role of Oral Forms of Collagen in Cosmetology Practice

The Role of Oral Forms of Collagen in Cosmetology Practice

Pyridinoline in Evaluation of Subchondral Remodeling and Cartilaginous Tissue Metabolism in Patients With Early Signs of Knee Osteoarthrosis

Protocols on correction of signs of undifferentiated connective tissue dysplasia using hardware and injection techniques in cosmetic patients

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