Bone Mineral Density and Bone Loss Measured at the Radius to Predict the Risk of Nonspinal Osteoporotic Fracture

Gnudi, S; Malavolta, Nazzarena; Lisi, Lucia; Ripamonti, C

doi:10.1359/jbmr.2001.16.6.1130

Cited by 22 publications

(19 citation statements)

References 29 publications

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“…Our results indicated that distal forearm bone loss is a predictor of incident non-vertebral fracture, independent of baseline BMD, in postmenopausal women and can be compared with data from other prospective studies [14][15][16][17][18][19], only one of them including men [19]. Riis et al reported that baseline forearm bone mass and rate of bone loss predisposed to the same extent to fractures [14], whereas, Gnudi et al reported that rate of bone loss at the proximal but not distal radius was significantly associated with fracture risk in women over the age of 65 years [15].…”

Section: Discussionsupporting

confidence: 51%

“…Riis et al reported that baseline forearm bone mass and rate of bone loss predisposed to the same extent to fractures [14], whereas, Gnudi et al reported that rate of bone loss at the proximal but not distal radius was significantly associated with fracture risk in women over the age of 65 years [15]. Nevertheless, in the OFELY study, women with incident fractures had 38-53% higher rates of bone loss prior to fracture compared with those without fracture, and bone loss in the highest tertiles at the distal, mid-, and ultra-distal radius was significantly associated with increased risk of all fractures [17].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, with studies suggesting that BMD change plays a stronger part [14][15][16][17] and others suggesting BMD change to be an independent but weak predictor of future fracture risk [18,19], the role of bone loss as a predictor of fracture risk still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Bone loss and the risk of non-vertebral fractures in women and men: the Tromsø study

et al. 2009

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Bone loss and the risk of non-vertebral fractures in women and men: the Tromsø study

et al. 2009

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“…9 As the life expectancy is increasing even in the developing countries, by the year 2035 the maximum number of osteoporosis cases in the world will be in India and China. 10 The current study had shown that increasing age has negative correlation with T-score forearm. More number of osteoporotic subjects were in 56-60 years age group as compared to 46-50 years.…”

Section: Discussionmentioning

confidence: 48%

Forearm bone mineral density in postmenopausal Indian women: correlation with calcium nutrition

Sharma¹,

Agarwal

Sharma

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Osteoporosis is characterized by low bone mass with micro architectural deterioration of bone tissue leading to enhanced bone fragility, thus increasing the susceptibility to fracture. This study was conducted with the objective of measuring forearm bone mineral density in postmenopausal Indian women and to establish a correlation with indices of calcium nutrition i.e. dietary calcium intake, calcium supplements, serum calcium, serum phosphorus, serum alkaline phosphatase and serum intact parathyroid hormone.Methods: Fifty healthy, ambulatory postmenopausal women were selected and a prospective observational study was conducted to correlate the BMD with indices of calcium nutrition. Patient’s laboratory investigations (serum calcium, serum phosphorous, serum alkaline phosphatase and serum intact parathyroid hormone were done and BMD was assessed with dual-energy X-ray absorptiometry at non-dominant forearm; T-scores and Z-score were derived. Correlation analysis was done to investigate the relationship between indices of calcium nutrition and BMD.Results: The proportion of osteoporosis in forearm was 22%in the deficient group, 60% in the insufficient group and 18% in the sufficient group. Among the study group 15 subjects were osteoporotic by T score mid forearm where as 7 were osteoporotic with T score ultra distal forearm and 11 subjects had osteoporosis with T score total forearm.Conclusions: Out of all the indices of calcium nutrition, the correlation between the serum alkaline phosphatase and T score forearm was statistically significant.

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“…The rate of bone loss, which is variable among postmenopausal women, has been postulated to be an independent risk factor for fracture [4,5]. However, few prospective studies have assessed the association between the rate of bone loss and the risk of fracture [6][7][8][9][10]. In three of these studies however, the rate of bone loss was only obtained from the forearm site [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Loss of hip bone mineral density over time is associated with spine and hip fracture incidence in osteoporotic postmenopausal women

et al. 2009

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The objective of the study assess the relationship between bone mineral density (BMD) loss over time and fracture incidence in postmenopausal women. This is a posthoc analysis that includes women from the placebo group of two large randomized controlled trials having assessed the efficacy of a new anti-osteoporotic drug. BMD was assessed every 6 months during 3 years at the lumbar spine, the femoral neck and the total proximal femur. Vertebral fractures were assessed using a semiquantitative method. Hip fractures were based on written documentation. All patients received calcium and vitamin D. In the present study that included 1,775 patients (with complete data at baseline and after 3 years), the logistic regression analysis, adjusted for covariates, showed that 3-year change in lumbar BMD was not statistically associated with the new vertebral fractures after 3 years. However, femoral neck and total proximal femur BMD changes was statistically correlated with the incidence of new vertebral fractures (P < 0.001). When considering change in BMD after the first year of follow-up, a decrease in total proximal femur BMD was statistically associated with an increase in the incidence of new vertebral fractures during the last 2 years of follow-up (P = 0.048). The 3-year change in femoral neck and total proximal BMD was statistically correlated with the incidence of hip and fragility fracture after 3 years (all P < 0.001). In this elderly osteoporotic population receiving calcium and vitamin D, a decrease in hip BMD after 1 or 3 year of follow-up, is associated with an increased risk of fracture incidence. However, spine BMD changes do not influence vertebral fracture incidence.

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Bone Mineral Density and Bone Loss Measured at the Radius to Predict the Risk of Nonspinal Osteoporotic Fracture

Cited by 22 publications

References 29 publications

Bone loss and the risk of non-vertebral fractures in women and men: the Tromsø study

Bone loss and the risk of non-vertebral fractures in women and men: the Tromsø study

Forearm bone mineral density in postmenopausal Indian women: correlation with calcium nutrition

Loss of hip bone mineral density over time is associated with spine and hip fracture incidence in osteoporotic postmenopausal women

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