Bone mineral content of the radius: Good correlations with physicochemical determinations in iliac crest trabecular bone of normal and osteoporotic subjects

Manicourt, Daniel; Orloff, Serge; Brauman, J; Schoutens, André

doi:10.1016/0026-0495(81)90219-5

Cited by 44 publications

(15 citation statements)

References 16 publications

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“…Magnesium contributes macroelement quantities to bone ash and is essential for appropriate calcium metabolism, affecting calcium balance (46,49). Cancellous bone in osteoporotic women has been shown to have a low magnesium content, which is associated with crystals that are more "perfect" and brittle than those seen in magnesium-replete bone (50,51). Despite the experimental and circumstantial evidence supporting the role of magnesium in maintaining bone health and preventing osteoporosis, few studies have evaluated this relation in humans.…”

Section: Discussionmentioning

confidence: 99%

Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women

Tucker

Hannan²,

Chen³

et al. 1999

The American Journal of Clinical Nutrition

610

396

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Background: Osteoporosis and related fractures will be growing public health problems as the population ages. It is therefore of great importance to identify modifiable risk factors. Objective: We investigated associations between dietary components contributing to an alkaline environment (dietary potassium, magnesium, and fruit and vegetables) and bone mineral density (BMD) in elderly subjects. Design: Dietary intake measures were associated with both cross-sectional (baseline) and 4-y longitudinal change in BMD among surviving members of the original cohort of the Framingham Heart Study. Dietary and supplement intakes were assessed by food-frequency questionnaire, and BMD was measured at 3 hip sites and 1 forearm site. Results: Greater potassium intake was significantly associated with greater BMD at all 4 sites for men and at 3 sites for women (P < 0.05). Magnesium intake was associated with greater BMD at one hip site for both men and women and in the forearm for men. Fruit and vegetable intake was associated with BMD at 3 sites for men and 2 for women. Greater intakes of potassium and magnesium were also each associated with less decline in BMD at 2 hip sites, and greater fruit and vegetable intake was associated with less decline at 1 hip site, in men. There were no significant associations between baseline diet and subsequent bone loss in women. Conclusion: These results support the hypothesis that alkalineproducing dietary components, specifically, potassium, magnesium, and fruit and vegetables, contribute to maintenance of BMD.Am J Clin Nutr 1999;69:727-36.

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Section: Discussionmentioning

confidence: 99%

Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women

Tucker

Hannan²,

Chen³

et al. 1999

The American Journal of Clinical Nutrition

610

396

View full text Add to dashboard Cite

show abstract

“…While most body Mg, 50-60%, resides in the skeleton, and skeletal Mg reflects Mg status, studies have reported low, normal or high bone Mg content in osteoporosis [39][40][41][42][43][44][45].…”

Section: Mg Status In Patients With Osteoporosismentioning

confidence: 99%

Magnesium deficiency and osteoporosis: animal and human observations

Rude

Gruber

2004

The Journal of Nutritional Biochemistry

287

170

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“…A number of studies have reported signi®cant reductions in serum Mg and bone Mg content in postmenopausal women with osteoporosis (Manicourt et al, 1981;Cohen, 1988;Reginster et al, 1989;Cohen & Laor, 1990;Stendig-Lindberg et al, 1993). However, epidemiological studies relating Mg intake to bone mass or rate of bone loss have been con¯icting (Yano et al, 1985;Fruedenheim et al, 1986;Angus et al, 1988;Tucker et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

The effect of magnesium supplementation on biochemical markers of bone metabolism or blood pressure in healthy young adult females

1999

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Objectives: To investigate the effects of increasing Mg intakes, above the usual dietary intake, on blood pressure and on biomarkers of bone metabolism in healthy young adult females. Design: A double-blind, placebo-controlled, randomised crossover Mg intervention trial. Setting: The study was conducted in the Department of Nutrition, University College, Cork, Ireland. Subjects: Twenty-six healthy (normotensive) adult females aged 20 ± 28 y were recruited from University College, Cork. Intervention: Subjects were randomly assigned to their self-selected diets ( $ 11 mmol Mgad) or their selfselected diet with a 10 mmolad Mg supplement as Mg(OH) 2 ( $ 22 mmol Mgad) for 28 d followed by cross-over to the alternative diet for a further 28 d. During each dietary period urines (last 3 d) and blood (morning of 27 d) were collected and blood pressure was measured on the morning of 28 d. Results: Increasing Mg intake from the usual level (11 mmolad) to 22 mmolad for 28 d increased urinary excretion of Mg by 36% and erythrocyte Mg content by 5% but had no effect on serum Mg, Ca, PTH, osteocalcin or bone-speci®c alkaline phosphatase (biomarkers of bone formation), urinary pyridinium crosslinks of collagen (biomarkers of bone resorption), or on blood pressure. Conclusion: Increasing the mean Mg intake in healthy young adult females above the usual dietary intake, which is currently above the US EAR (estimated average requirement), but below the US RDA for Mg, does not affect blood pressure or the rate of bone turnover. Sponsorship: Funding from the Department of Agriculture and Food, Dublin.

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Bone mineral content of the radius: Good correlations with physicochemical determinations in iliac crest trabecular bone of normal and osteoporotic subjects

Cited by 44 publications

References 16 publications

Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women

Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women

Magnesium deficiency and osteoporosis: animal and human observations

The effect of magnesium supplementation on biochemical markers of bone metabolism or blood pressure in healthy young adult females

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