Bone Mineral Content Deficits of the Spine and Whole Body in Children at Time of Diagnosis With Celiac Disease

Jatla, Muralidhar; Zemel, Babette S.; Bierly, Patricia; Verma, Ritu

doi:10.1097/mpg.0b013e318177e621

Cited by 28 publications

(25 citation statements)

References 48 publications

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“…However, the optimal timing of this in children is not clear. There are recent data to suggest that there are a number of risk factors in children with CD, including reduced bone density, the severity of the small bowel lesion, and low body mass index 84. The frequency of bone densitometry in both adults and children should be guided by a number of factors including the age of the patient, menopausal status, the presence of low minimal trauma fractures, the initial bone density, and the presence of ongoing intestinal changes 85.…”

Section: Long Term Management Of CDmentioning

confidence: 99%

Diagnosis and management of coeliac disease in children

Steele¹

2010

Postgraduate Medical Journal

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Coeliac disease (CD) remains under diagnosed with only 10-20% of patients identified. Genes encoding HLA DQ2 or DQ8 are found in the vast majority of those with CD and testing for their presence can be useful to rule out the possibility CD. CD is more common in certain ethnic groups including those of North Indian origin. The classical presentation tends to occur in younger children, while atypical presentations occur at an older age. The number of children being diagnosed with CD is increasing; this may be due to greater recognition of the more atypical presentations, improved serologic tests, and the screening of asymptomatic groups at increased risk, but may also be due to an overall increased prevalence. Although serologic testing has become more reliable, there still remain significant problems around testing, particularly in those <18 months of age. All children should undergo a duodenal biopsy on a gluten containing diet in order to diagnose CD before recommending a gluten-free diet (GFD). A GFD should be offered to all children diagnosed with CD even when perceived as asymptomatic, as there is significant morbidity associated with CD later in life.

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Section: Long Term Management Of CDmentioning

confidence: 99%

Diagnosis and management of coeliac disease in children

Steele¹

2010

Postgraduate Medical Journal

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“…Анализ взаимосвязи между антропометрическими показателями и костным возрастом детей с целиакией подчеркивает существующую прямую корреляцию между нарушением скорости роста и задержкой созревания костного скелета [51,52]. Замедление темпов линейного роста закономерно приводит к снижению МПКТ [52].…”

Section: Vdr Vdrunclassified

“…Замедление темпов линейного роста закономерно приводит к снижению МПКТ [52]. По данным R. Heyman и соавт., задержка костного возраста и снижение минерализации костной ткани формируются у 59% пациентов [51].…”

Section: Vdr Vdrunclassified

Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease

Klimov¹,

Абрамская²,

Stoian³

et al. 2017

Med. sov.

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“…Despite recent advances in testing, delay in diagnosis remains an issue and children may have longstanding mucosal damage and malabsorption prior to diagnosis [5]. Previous studies have shown that altered bone metabolism and decreased bone mineral content in children with CD leads to osteoporosis and potential increased risk of fracture [3,6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Malabsorption is secondary to loss of villous cells in the small intestine leading to impaired absorption of nutrients [1]. With this loss, alteration of calcium absorption negatively influences bone development and bone density [3,4]. Despite recent advances in testing, delay in diagnosis remains an issue and children may have longstanding mucosal damage and malabsorption prior to diagnosis [5].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Variation in Use of Screening DXA Scans in Pediatric Patients with Celiac Disease

Webster¹,

Shaw²,

Shea³

et al. 2017

IJCD

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Celiac disease (CD) is an immune-mediated genetic disorder occurring secondary to gluten exposure and increasing the likelihood of low bone mineral density (BMD). As there are no published guidelines for dual-x-ray absorptiometry (DXA) scanning in pediatric CD patients, we characterized current practices of pediatric gastroenterologists in ordering screening DXA scans for pediatric CD patients. To accomplish this, A REDCap survey was distributed to the NASPGHAN listserv. There was a total of 231 (11%) responses. The majority (60%) of clinicians do not order screening DXA scans because they don't believe it is clinically necessary. Patient factors influenced ordering screening DXA scans with fracture history driving ordering and tissue transglutaminase (tTG) level not affecting practice. Physician factors such as practice type and experience were not associated with ordering screening DXA scans. Case scenarios, showed wide variation in management based on DXA results.

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Bone Mineral Content Deficits of the Spine and Whole Body in Children at Time of Diagnosis With Celiac Disease

Abstract: Newly diagnosed children with CD may benefit from screening for low bone mineral content. Patients with low body mass index and those with advanced histological damage (Marsh grade IIIc) particularly may be at risk for osteopenia.

Cited by 28 publications

References 48 publications

Diagnosis and management of coeliac disease in children

Diagnosis and management of coeliac disease in children

Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease

Understanding the Variation in Use of Screening DXA Scans in Pediatric Patients with Celiac Disease

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