Bone metastasis as primary presentation of pancreatic ductal adenocarcinoma: A case report and literature review

Argentiero, Antonella; Calabrese, Angela; Solimando, Antonio Giovanni; Notaristefano, Antonio; Panarelli, Marzia M.G.; Brunetti, Oronzo

doi:10.1002/ccr3.2412

Cited by 15 publications

(12 citation statements)

References 42 publications

(85 reference statements)

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“…However, there are only a few reports combining basic research and clinical aspects of MSPC. Therefore, it is necessary to encourage the enrollment of patients in clinical trials, including their genetic and molecular characterization, and to combine standard chemotherapy utilizing treatment by bone-modifying agents with MSPC is a clinical challenge with unexplained biological characteristics (32). The systemic treatment of MSPC would be an exciting and promising research topic.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and surgical treatment of spinal metastases from pancreatic cancer: a single-center retrospective study

Liu¹,

Zhou²,

Song³

et al. 2021

Ann Palliat Med

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Background: To improve the understanding of the characteristics of rare pancreatic cancer spinal metastatic disease and share our experience in coping with this disease. Although spinal metastasis of pancreatic cancer is extremely rare clinically, and the prognosis of the primary tumor is very poor, pancreatic cancer spinal metastasis has received insufficient attention in clinical practice and is only described in a limited number of case reports or series. The purpose of the present study is to discuss the clinical features, prognostic characteristics, and treatment of individuals with pancreatic cancer spinal metastases.Methods: Four patients with clinical symptoms caused by metastatic spinal pancreatic cancer (MSPC) were selected from patients treated in our department between January 2010 and January 2020. Patients' clinical and surgical records, imaging data, and pathology reports were reviewed by our team. A retrospective analysis of patient clinical data was conducted.Results: Of the four patients, one was male and three were female. The average age was 68.0 (range, 61-79) years old. The average time between the pancreatic cancer diagnosis and the diagnosis of spinal metastases was 10.5 (range, 0-24) months. Spinal metastatic disease was primarily found in the thoracic spine (n=3; 75.0%), and the lumbar spine (n=2; 50.0%). During follow-up, local tumor progression was found in all four patients (100%), all of whom died of pancreatic cancer during follow-up visits. The median time between spinal surgery and death was 16.3 (range, 12-19) months.Conclusions: Taken together, pancreatic cancer patient that have spinal metastases exhibit a poor prognosis, with a survival time shorter than for any other malignant tumor. Percutaneous vertebroplasty may become an effective treatment option for pancreatic cancer spinal metastasis, which can significantly improve the patient's symptoms.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and surgical treatment of spinal metastases from pancreatic cancer: a single-center retrospective study

Liu¹,

Zhou²,

Song³

et al. 2021

Ann Palliat Med

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“…[ 4 ] Furthermore, Argentiero et al . reported a PDAC patient with metastatic lesions in L3, T10, T11, the right iliac wing and crest, left clavicle, and bilateral ribs,[ 1 ] while an additional study reported a patient with severe lower back pain and osteoblastic lumbar vertebral lesions. [ 7 ] Finally, Rades et al .…”

Section: Discussionmentioning

confidence: 99%

Metastatic epidural spinal column compression due to pancreatic ductal adenocarcinoma causing subacute Cauda equina syndrome: A case report

Diaz-Aguilar

Sahyouni

Brown

et al. 2020

Surgical Neurology International

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Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy, which rarely metastasizes to the spine. Case Description: Here, we present a lytic lumbar metastatic PDAC resulting in severe epidural spinal cord compression (ESCC) with instability. The lesion required preoperative particle embolization, surgical decompression, and fusion. Conclusion: This case report shows that PDAC may metastasize to the lumbar spine requiring routine decompression with fusion.

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“… 124 In pancreatic cancer, the most common metastatic site is the liver, followed by the lungs, peritoneum, and bones. 125 – 127 Recently, Lee et al reported that activation of STAT3 in hepatocytes and the subsequent production of serum amyloid A1 and A2 in the bloodstream direct pancreatic cancer liver metastasis. 128 Interestingly, lineage-tracing analysis in a mouse model of pancreatic cancer revealed that metastases in the lung and liver are monoclonal, whereas those in the peritoneum and diaphragm tend to be polyclonal.…”

Section: Characteristics Of Pancreatic Cancermentioning

confidence: 99%

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

Wang

Zheng

Yang

et al. 2021

Sig Transduct Target Ther

173

128

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Pancreatic cancer is an increasingly common cause of cancer mortality with a tight correspondence between disease mortality and incidence. Furthermore, it is usually diagnosed at an advanced stage with a very dismal prognosis. Due to the high heterogeneity, metabolic reprogramming, and dense stromal environment associated with pancreatic cancer, patients benefit little from current conventional therapy. Recent insight into the biology and genetics of pancreatic cancer has supported its molecular classification, thus expanding clinical therapeutic options. In this review, we summarize how the biological features of pancreatic cancer and its metabolic reprogramming as well as the tumor microenvironment regulate its development and progression. We further discuss potential biomarkers for pancreatic cancer diagnosis, prediction, and surveillance based on novel liquid biopsies. We also outline recent advances in defining pancreatic cancer subtypes and subtype-specific therapeutic responses and current preclinical therapeutic models. Finally, we discuss prospects and challenges in the clinical development of pancreatic cancer therapeutics.

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Bone metastasis as primary presentation of pancreatic ductal adenocarcinoma: A case report and literature review

Abstract: PDAC bone metastases represent a clinical challenge characterized by multifaceted biological entity.

Cited by 15 publications

References 42 publications

Clinical characteristics and surgical treatment of spinal metastases from pancreatic cancer: a single-center retrospective study

Clinical characteristics and surgical treatment of spinal metastases from pancreatic cancer: a single-center retrospective study

Metastatic epidural spinal column compression due to pancreatic ductal adenocarcinoma causing subacute Cauda equina syndrome: A case report

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

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