Bone metabolism and oxidative stress in postmenopausal rats with iron overload

Isomura, Haruo; Fujie, Katsutoshi; Shibata, Kouichi; Inoue, Nozomu; Iizuka, Tadashi; Takebe, Gen; Takahashi, Kazuhiko; Nishihira, Jun; Izumi, Hiroshi; Sakamoto, Wataru

doi:10.1016/j.tox.2003.12.006

Cited by 131 publications

(87 citation statements)

References 26 publications

(28 reference statements)

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“…By searching for factor(s) other than estrogen deficiency in osteoporosis, we found that both dietary iron deficiency and overload affect bone in animal studies (8,18,19,21,23,29). One recent report showed that osteoporosis patients are slightly iron deficient, having lower serum iron and higher transferrin as compared with the control group (7).…”

Section: Iron and Osteoporosismentioning

confidence: 99%

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Jian

Pelle

Huang

2009

Antioxidants & Redox Signaling

142

125

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Estrogen deficiency has been regarded as the main causative factor in menopausal symptoms and diseases. Here, we show that although estrogen decreases by 90%, a concurrent but inverse change occurs in iron levels during menopausal transition. For example, levels of serum ferritin are increased by two-to threefold from before menopause to after menopause. This observation has led us to hypothesize that, in addition to estrogen deficiency, increased iron as a result of menopause could be a risk factor affecting the health of postmenopausal women. Further studies on iron and menopause are clinically relevant and may provide novel therapeutic treatments.

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Section: Iron and Osteoporosismentioning

confidence: 99%

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Jian

Pelle

Huang

2009

Antioxidants & Redox Signaling

142

125

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“…[9][10][11] Three iron chelation therapies have been approved for clinical use: deferoxamine (DFO), deferiprone (DFP) and deferasirox (DFX). 12 DFO inhibits DNA synthesis, osteoblast and fibroblast proliferation, and collagen formation, and enhances osteoblast apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels

et al. 2014

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“…3 Both in vitro and animal experiments indicate that iron may play a role in bone formation and/or destruction. [6][7][8] An increased amount of iron has been associated with reduced in vitro osteoblast proliferation 9 and extracellular calcium deposition. 10 In a mouse model, iron dextran injection increased the osteoclast population in the bone structure and reduced the number and thickness of trabeculae.…”

Section: Introductionmentioning

confidence: 99%

Predictors of osteoclast activity in patients with sickle cell disease

Nouraie¹,

Cheng²,

Niu³

et al. 2011

Haematologica

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BackgroundBone changes are common in sickle cell disease, but the pathogenesis is not fully understood. Tartrate-resistant acid phosphatase (TRACP) type 5b is produced by bone-resorbing osteoclasts. In other forms of hemolytic anemia, increased iron stores are associated with osteoporosis. We hypothesized that transfusional iron overload would be associated with increased osteoclast activity in patients with sickle cell disease. Design and MethodsWe examined tartrate-resistant acid phosphatase 5b concentrations in patients with sickle cell disease and normal controls of similar age and sex distribution at steady state. Serum tartrateresistant acid phosphatase 5b concentration was measured using an immunocapture enzyme assay and plasma concentrations of other cytokines were assayed using the Bio-Plex suspension array system. Tricuspid regurgitation velocity, an indirect measure of systolic pulmonary artery pressure, was determined by echocardiography. ResultsTartrate-resistant acid phosphatase 5b concentrations were higher in 58 adults with sickle cell disease than in 22 controls (medians of 4.4 versus 2.4 U/L, respectively; P=0.0001). Among the patients with sickle cell disease, tartrate-resistant acid phosphatase 5b independently correlated with blood urea nitrogen (standardized beta=0.40, P=0.003), interleukin-8 (standardized beta=0.30, P=0.020), and chemokine C-C motif ligand 5 (standardized beta=-0.28, P=0.031) concentrations, but not with serum ferritin concentration. Frequent blood transfusions (>10 units in life time) were not associated with higher tartrate-resistant acid phosphatase 5b levels in multivariate analysis. There were strong correlations among tartrate-resistant acid phosphatase 5b, alkaline phosphatase and tricuspid regurgitation velocity (r>0.35, P<0.001). ConclusionsPatients with sickle cell disease have increased osteoclast activity as reflected by serum tartrateresistant acid phosphatase 5b concentrations. Our results may support a potential role of inflammation rather than increased iron stores in stimulating osteoclast activity in sickle cell disease. The positive relationships among tartrate-resistant acid phosphatase 5b, alkaline phosphatase and tricuspid regurgitation velocity raise the possibility of a common pathway in the pulmonary and bone complications of sickle cell disease.Key words: sickle cell disease, osteoclast activity, bone turnover, inflammation, TRACP 5b, pulmonary complications.Citation: Nouraie M, Cheng K, Niu X, Moore-King E, Fadojutimi-Akinsi MF, Minniti CP, Sable C, Rana S, Dham N, Campbell A, Ensing G, Kato GJ, Gladwin MT, Castro OL, and Gordeuk VR. Predictors of osteoclast activity in sickle cell disease patients. Haematologica 2011;96(8):1092-1098. doi:10.3324/haematol.2011 This is an open-access paper. Predictors of osteoclast activity in patients with sickle cell disease

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Bone metabolism and oxidative stress in postmenopausal rats with iron overload

Cited by 131 publications

References 26 publications

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?

Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels

Predictors of osteoclast activity in patients with sickle cell disease

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