Bone metabolism and incretin hormones following glucose ingestion in young adults with pancreatic insufficient cystic fibrosis

Lei, Wang Shin; Kilberg, Marissa J; Zemel, Babette S.; Rubenstein, Ronald C.; Harris, Clea; Sheikh, Saba; Kelly, Andrea; Kindler, Joseph M.

doi:10.1016/j.jcte.2022.100304

Cited by 2 publications

(1 citation statement)

References 53 publications

(76 reference statements)

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“…Patients with cystic fibrosis and pancreatic insufficiency have been used as human cases in studies exploring the relation between a loss of GIP function and changes in bone resorption. In these patients, the decrease in CTX during an oral glucose tolerance test correlated with the increase in GIP [46]. A randomized controlled cross-over study with GIP-RA/ GLP-2 receptor agonist co-administration reported a larger suppression of bone resorption markers compared to treatment with either GIP or GLP-2 alone in ten healthy men [47 && ].…”

Section: Glp-1mentioning

confidence: 99%

Effect of incretins on skeletal health

Starup-Linde

Hygum

Langdahl

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewThe incretin hormones, glucagon like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), have been shown to decrease bone resorption in humans. The aim of this review is to collate evidence and current advances in the research within the last year on the effect of incretins on skeletal health. Recent findingsPreclinical studies show potential direct beneficial effects on bone by GLP-1 and GIP, however real world epidemiological data show no effects of GLP-1 receptor analogues on fracture risk. This may be due to the weight loss accompanied by GLP-1 treatment which may have detrimental effects on bone. GIP is shown to reduce bone resorption and increase bone formation. Further evidence suggests an additive effect of GIP and glucagon like peptide-2, which could affect bone by different mechanisms.

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Section: Glp-1mentioning

confidence: 99%