Abstract:Patients at high risk of fracture due to metabolic diseases frequently undergo long-term antiresorptive therapy. However, in some patients treatment is unsuccessful in preventing fractures or causes severe adverse health outcomes. Understanding load driven bone remodelling, i.e. mechanoregulation, is critical to understand which patients are at risk for progressive bone degeneration and may enable better patient selection or adaptive therapeutic intervention strategies. Bone microarchitecture assessment using … Show more
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