Bone mass status in different degrees of chronic renal failure

Efficacy and Safety of Denosumab for the Treatment of Osteoporosis in Patients with Chronic Kidney Disease

“…Patients with CKD are likely to be older and have lower levels of vitamin D. In addition, there is increasing evidence that CKD itself is a risk factor for low BMD [4][5][6][7]. Patients with impaired renal function have been found to have greater rates of bone loss [7,20]. Nickolas et al reported an independent correlation between an eGFR <60 mL/min/1.73 m 2 and the prevalence of hip fractures [21].…”

Association of Bone Mineral Density with Albuminuria and Estimated Glomerular Filtration Rate : The Dong-gu Study

“…Previous studies have investigated the associations between renal insufficiency and BMD, but the results were conflicting [8,9,10,11,12,13,34,35,36]. A few small studies have indicated that renal insufficiency is related to low bone mass [8,9,10,11,12,13], but data from more extensive studies have indicated that such an association could be explained by confounding factors, primarily sex, age, and weight [34,35,36]. …”

“…Furthermore, individuals with renal insufficiency may also exhibit reduced BMD as a result of vitamin D-parathyroid hormone (PTH) homeostasis and metabolic acidosis [7]. Previous studies have reported that kidney dysfunction is associated with BMD [8,9,10,11,12,13]. However, because of small sample sizes and the result that the associations disappeared after adjusting for key confounders, such as sex, age and weight, the significance of those findings is uncertain.…”

Causes and Consequences of Adynamic Bone Disease

“…Indeed, one study [12]found the development of ABD to be associated with a rising BMD. HPT poses the greatest risk for bone loss in most studies [22, 23, 24, 25, 26, 27, 28, 29, 30, 31], with the occasional exception [32]. Parathyroidectomy reduces, or even reverses the rate of bone loss [30, 33].…”