Bone mass increases in less than 4 wk of voluntary exercising in growing rats

Holy, Xavier; Zérath, E.

doi:10.1097/00005768-200009000-00006

Cited by 34 publications

(36 citation statements)

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“…This difference might have been caused by the difference in the age of the rats. The age of the rat in the exercise and food restriction phase was lower in our study (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) weeks old) than in Dimarco et al's study (17-30 weeks old). Our findings could suggest that young female rats may be sensitive to the negative effects of the interaction of voluntary running exercise and food restriction.…”

Section: Discussioncontrasting

confidence: 75%

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The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats

et al. 2015

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There is a concern that the combination of exercise with food intake reduction has a risk of reducing bone strength and bone mass in young female athletes. We examined the influence of the interaction of voluntary running exercise and food restriction on bone in young female rats. Seven-week-old female Sprague-Dawley rats were divided into four groups: the sedentary and ad libitum feeding group (SED), voluntary running exercise and ad libitum feeding group (EX), sedentary and 30 % food restriction group (SED-FR), and voluntary running exercise and 30 % food restriction group (EX-FR). The experiment lasted 12 weeks. Statistical analysis was carried out by two-way analysis of variance with exercise and restriction as the between-subjects factors. As a result, there were significant interactions of running and restriction on energy availability, breaking force, breaking energy, and bone mineral density (BMD). Breaking force and energy in the EX group were significantly higher than in the SED group; breaking force and energy were significantly lower in the EX-FR group than in the EX group, and breaking force in the EX-FR group was significantly lower than that in the SED-FR group. BMD in the EX-FR group was significantly lower than in the EX and SED-FR groups. These results suggest that food restriction induced low bone strength in young female rats engaging in voluntary running exercise. Also, through the interaction of exercise and food restriction, voluntary running exercise combined food restriction, unlike ad libitum feeding conditions, induced low bone strength, and low BMD in young female rats.

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Section: Discussioncontrasting

confidence: 75%

“…In previous studies, it has been reported that running exercise under ad libitum feeding conditions in female rats induced high bone mass [16] or high BMD [3,17]. However, the influence of running exercise on bone in female rats has not been reported under food restriction conditions.…”

Section: Introductionmentioning

confidence: 95%

The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats

et al. 2015

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“…We have no explanation for the apparent discrepancy, but we note that blood withdrawn during animal sacrifice only represents a snapshot at a single time point and not the sustained activity of osteoblasts and/or osteoclasts throughout the training period. In support, several studies have demonstrated training-induced elevations in BMD in the absence of any alterations in serum biomarkers (7,19). Therefore, we recognize the significant limitation of extrapolating on bone cell activity fi-om a single serum sample taken at one time point.…”

Section: Discussionmentioning

confidence: 95%

High Volumes of Resistance Exercise Are Not Required for Greater Bone Mineral Density during Growth

Ahles

Singh²,

Joo³

et al. 2013

Medicine &Amp; Science in Sports &Amp; Exercise

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“…In both instances, resumption of activity leads to restoration of bone. It is also known that bone mass increases with mechanical stress (Maddalozzo & Snow, 2000;Swezey, Swezey, & Adams, 2000), and that those who engage in aerobic activity have higher bone density than those who do not (Bidoli, Schinella, & Franceschi, 1998;Coupland et al 1999;Holy & Zerath, 2000;Kano, 1998). The relationship between calcium intake and bone is well established (Holm & Walker, 1990;Reid, Ames, Evans, Sharpe, & Gamble, 1994;Soroko, Holbrook, Edelstein, & Barrett-Connor, 1994;Weaver, 2000;Wolf et al, 2000).…”

Section: Physical Activitymentioning

confidence: 99%

A Longitudinal Study of Bone Density in Midlife Women

Holm

Dan

Wilbur

et al. 2002

Health Care for Women International

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A longitudinal study of 386 healthy Black and White women aged 35-60 years was conducted to determine the effects of physical activity and other related factors on lumbar bone mineral density over 24 months. Bone mineral density of the lumbar spine, L2-L4, was measured using dual energy x-ray (Hologic 1000). Physical activity levels in three dimensions (leisure, household, and occupational) from both a lifelong and current perspective were obtained by questionnaire. Body mass index was calculated from measured weight in kilograms divided by measured height in meters squared. Calcium, caffeine, and alcohol intake was estimated using a food frequency questionnaire. Age, race, and smoking were determined by self-report. Radioimmunoassays of follicle stimulating hormone (FSH) and estradiol were used to validate self-reports of menopausal status. Multiple regression analysis revealed that race, age, weight, FSH, calcium, and years of tobacco intake formed the best model at baseline (r(2) = 0.32) and at 24 months (r(2) = 0.303). Physical activity was not a significant predictor for bone mineral density at either time point. There were cross-sectional changes of bone mineral density with race, age, and menopausal status. Black women had significantly higher bone mineral density than White women. However, an age-related decline in bone mineral density was exhibited in both Black and White women. Perimenopausal women had significantly lower bone mineral density as compared with premenopausal women. Furthermore 37 (9.6%) women at baseline and 34 (11%) at 24 months were designated at risk for fracture.

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Bone mass increases in less than 4 wk of voluntary exercising in growing rats

Abstract: Daily spontaneous exercise training induced an increase in bone mass and bone volume in less than 4 wk. Further studies are needed to fully investigate these changes during the very first days of exercising.

Cited by 34 publications

References 0 publications

The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats

The Interaction of Voluntary Running Exercise and Food Restriction Induces Low Bone Strength and Low Bone Mineral Density in Young Female Rats

High Volumes of Resistance Exercise Are Not Required for Greater Bone Mineral Density during Growth

A Longitudinal Study of Bone Density in Midlife Women

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