Bone mass in Saudi women aged 20–40 years: the association with obesity and vitamin D deficiency

Albaik, Mai; Khan, Jalaluddin A.; Sindi, Ikhlas A.; Åkesson, Kristina; McGuigan, Fiona

doi:10.1007/s11657-022-01164-z

Cited by 5 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dual-energy X-ray absorptiometry (DEXA) is the preferred golden standard tool for the assessment of BMD. A recent Saudi study of females between the ages of 20 and 40 reported a low T-score in 19% of the participants using DEXA, the golden standard test [43]. Evaluation of low BMD in premenopausal women is challenging.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Z-Score of Bone Mineral Density among Premenopausal Saudi Females in Different Age Groups: A Cross Sectional Study

Sultan,

Taha,

El Tarhouny

et al. 2023

Nutrients

View full text Add to dashboard Cite

This is a comparative multicenter cross-sectional study that evaluated the potential determinants of Z-scores among premenopausal Saudi women before and after the age of peak bone density. The Study concluded that for better BMD among premenopausal women, attention should be paid to early physical activity and healthy nutrition, especially vitamin D, during the childbearing period. Objective: To explore the potential determinants of Z-scores among premenopausal Saudi females in different age groups before and after the expected age of peak bone density (PBD). Methods: This multicenter comparative cross-sectional study was conducted in Madinah and Jeddah, Saudi Arabia, between August 2021 and March 2022. We recruited 886 premenopausal females (605 (68.3%) below and 281 (31.7%) at or above the age of 30). The structured pre-coded Arabic questionnaire included sociodemographic data, a BMD questionnaire, menstrual history, an Arab Teen Lifestyle Study questionnaire, and food frequency data. Metabolic Equivalents (METs) were calculated from physical activity. Analysis of serum PTH, 25(OH) vitamin D (VD) was performed with chemiluminescent immunoassay. BMD was measured with a calcaneal qualitative ultrasound. Results: Most women had age-matched Z-scores, with very few (24 (2.7%)) being non-age-matched with no identified secondary causes. Significant Z-score determinants before PBD were BMI (OR: 0.167, p = 0.003) and total METs (OR: 0.160, p < 0.005). After the age of PBD, significant predictors were parity (OR: 0.340, p = 0.042), history of vitamin D deficiency (OR: 0.352, p = 0.048), and BMI (OR: 0.497, p = 0.019). Conclusions: Early determinants of Z-scores among premenopausal women were the nutritional status and physical activity. After the age of PBD, parity and vitamin D status offer additional determinants. For better BMD, attention should be paid to early physical activity and healthy nutrition, especially for vitamin D, with intensification of efforts during the childbearing period.

show abstract

Section: Discussionmentioning

confidence: 99%

Determinants of Z-Score of Bone Mineral Density among Premenopausal Saudi Females in Different Age Groups: A Cross Sectional Study

Sultan,

Taha,

El Tarhouny

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…47 Chain et al, 48 further suggest that muscle strength losses or dynapenia, obesity, and their combination may affect bone density in a sex-dependent manner, in that the presence of dynapenia, and excess fat mass appears to exert a protective effect on bone density in women, but not in men. However, not all agree, and the obese subject can be found to have a have lower bone quality rather than a higher one, regardless of their obesity phenotype, 1 women who are in the normal weight range, but younger than post menopausal women may have low bone mineral density, 49 and although bone mineral density is found to be higher on average in obese young women, this may not be beneficial later in life in the face of any persistent vitamin D deficiency. 50 Recommendations by Bialo et al, 51 appear relevant here.…”

Section: Discussionmentioning

confidence: 99%

Obesity and bone health: key 2020–2022 highlights and implications

Marks¹

2022

AOWMC

View full text Add to dashboard Cite

Sound bone health is crucial for life affirming activities, but is bone physiology impacted in the face of excess body weight? Since fractures and osteoporosis are on the rise, is obesity a risk factor for, as well as a possible negative albeit remediable correlate of bone health in the older adult? To examine this premise the PUBMED and GOOGLE SCHOLAR data bases were sourced for relevant data published between January 1 2020 and November 1 2022 in an effort to capture post COVID-19 possible research observations on the topic. These data bases show while a pervasive idea has been that obesity may be beneficial in some respects to bone mineral density attributes and impart fracture protection, several current publications tend to portray a negative impact of obesity on bone health via multiple proposed mechanisms. However, the research points to a strong need for continued research as well as clinical vigilance of vulnerable individuals both young and old in a period where obesity rates in all age groups appear to be on the rise, along with cases of bone fragility and osteoarthritis that can both foster high morbidity and mortality rates and possibly more challenging weight issues in the face of painful fractures or joint derangement.

show abstract

“…Obese individuals have difficulty absorbing vitamin B12 and vitamin D, which is not conducive to bone tissue remodeling ( 30 ). In a previous study, 86.2% of obese women were reported to be deficient in vitamin D and had difficulty absorbing calcium ( 31 ). Vitamin D deficiency can alter adipogenesis, lipogenesis and lipolysis, and exacerbate obesity ( 32 ).…”

Section: Obesity-induced Osteoporosismentioning

confidence: 99%

Obesity and lipid metabolism in the development of osteoporosis (Review)

Wang,

Zhang,

Zhao

et al. 2024

Int J Mol Med

View full text Add to dashboard Cite

Osteoporosis is a common bone metabolic disease that causes a heavy social burden and seriously threatens life. Improving osteogenic capacity is necessary to correct bone mass loss in the treatment of osteoporosis. Osteoblasts are derived from the differentiation of bone marrow mesenchymal stem cells, a process that opposes adipogenic differentiation. The peroxisome proliferator-activated receptor γ and Wnt/β-catenin signaling pathways mediate the mutual regulation of osteogenesis and adipogenesis. Lipid substances play an important role in the occurrence and development of osteoporosis. The content and proportion of lipids modulate the activity of immunocytes, mainly macrophages, and the secretion of inflammatory factors, such as IL-1, IL-6 and TNF-α. These inflammatory effectors increase the activity and promote the differentiation of osteoclasts, which leads to bone imbalance and stronger bone resorption. Obesity also decreases the activity of antioxidases and leads to oxidative stress, thereby inhibiting osteogenesis. The present review starts by examining the bidirectional differentiation of BM-MScs, describes in detail the mechanism by which lipids affect bone metabolism, and discusses the regulatory role of inflammation and oxidative stress in this process. The review concludes that a reasonable adjustment of the content and proportion of lipids, and the alleviation of inflammatory storms and oxidative damage induced by lipid imbalances, will improve bone mass and treat osteoporosis. Contents1. Introduction 2. Obesity-induced osteoporosis 3. Balance of osteogenesis and adipogenesis 4. Hyperlipemia-induced pathological changes and osteoporosis 5. Lipids and osteoporosis 6. Obesity in postmenopausal osteoporosis 7. Lipid metabolism disorders in osteoporotic patients with diabetes 8. discussion

show abstract

Bone mass in Saudi women aged 20–40 years: the association with obesity and vitamin D deficiency

Cited by 5 publications

References 34 publications

Determinants of Z-Score of Bone Mineral Density among Premenopausal Saudi Females in Different Age Groups: A Cross Sectional Study

Determinants of Z-Score of Bone Mineral Density among Premenopausal Saudi Females in Different Age Groups: A Cross Sectional Study

Obesity and bone health: key 2020–2022 highlights and implications

Obesity and lipid metabolism in the development of osteoporosis (Review)

Contact Info

Product

Resources

About