Bone Mass, Bone Microstructure and Biomechanics in Patients with Hand Osteoarthritis

Abstract

The impact of primary hand osteoarthritis (HOA) on bone mass, microstructure, and biomechanics in the affected skeletal regions is largely unknown. HOA patients and healthy controls (HCs) underwent high‐resolution peripheral quantitative computed tomography (HR‐pQCT). We measured total, trabecular, and cortical volumetric bone mineral densities (vBMDs), microstructural attributes, and performed micro–finite element analysis for bone strength. Failure load and scaled multivariate outcome matrices from distal radius and second metacarpal (MCP2) head measurements were analyzed using multiple linear regression adjusting for age, sex, and functional status and reported as adjusted Z‐score differences for total and direct effects. A total of 105 subjects were included (76 HC: 46 women, 30 men; 29 HOA: 23 women, six men). After adjustment, HOA was associated with significant changes in the multivariate outcome matrix from the MCP2 head (p < .001) (explained by an increase in cortical vBMD (Δz = 1.07, p = .02) and reduction in the trabecular vBMD (Δz = −0.07, p = .09). Distal radius analysis did not show an overall effect of HOA; however, there was a gender‐study group interaction (p = .044) explained by reduced trabecular vBMD in males (Δz = −1.23, p = .02). HOA was associated with lower failure load (−514 N; 95%CI, −1018 to −9; p = 0.05) apparent in males after adjustment for functional status. HOA is associated with reduced trabecular and increased cortical vBMD in the MCP2 head and a reduction in radial trabecular vBMD and bone strength in males. Further investigations of gender‐specific changes of bone architecture in HOA are warranted. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

Die periartikuläre Demineralisation bei rheumatoider Arthritis

“…AnhanddesHR-pQCTisteineDarstellungderKnochenmikro struktur und Knochengeometrie sowie eine volumetrische Kno chenmineraldichtemessung am distalen Radius sowie im Bereich derMetakarpophalangealgelenkeII-IVdurchführbar [16].Diege wonnenenvolumetrischenKnochenmineraldichtemessdatenkönn ten hier in Bezug auf die Gesamtknochenmineraldichte, trabeku läre Knochenmineraldichte und kortikale Knochenmineraldich tedifferenziertwerden [17].DasVerfahrenzeigteinesehrgute Reproduzierbarkeit(Knochengeometrie-Variationskoeffizient: 0,2 % -2,5 %; Mikrostruktur des trabekulären Knochens -Variati onskoeffizient:0,7%-2,4%;Knochenmineraldichte-Variations koeffizient:0,6%-1,7%undkortikaleDicke-Variationskoeffizient: 1,1%-1,3%) [18].…”

Association between radiographic hand osteoarthritis and bone microarchitecture in a population-based sample

“…Advanced technology such as high-resolution peripheral quantitative computed tomography (HRpQCT) provides new insight into the impact that HOA has on bone microarchitecture and to date there have been limited in vivo studies in this area. A recent study reported on the HRpQCT changes at the second metacarpal head (MCP2) and radius between healthy individuals and HOA patients [ 7 ]. While the study was relatively small, it suggested that clinical HOA was associated with reduced trabecular and increased cortical bone mass in the MCP2 head [ 7 ].…”

“…A recent study reported on the HRpQCT changes at the second metacarpal head (MCP2) and radius between healthy individuals and HOA patients [ 7 ]. While the study was relatively small, it suggested that clinical HOA was associated with reduced trabecular and increased cortical bone mass in the MCP2 head [ 7 ]. Our study aims to extend these findings by describing the relationship between radiographic HOA and HRpQCT measures of the hand, wrist, and radius in a population-based study of older adults.…”

Intra-articular low-dose parathyroid hormone (1-34) improves mobility and articular cartilage quality in a preclinical age-related knee osteoarthritis model

“… 9 - 18 Subchondral sclerosis is common in late-stage OA; however, some studies have observed thinning of the subchondral plate with increased porosity and deteriorated subchondral trabeculae with decreased bone density in early-stage OA. 15 , 19 - 22 Therefore, the role of subchondral bone in OA remains unclear.…”