Bone Mass and Soft Tissue Compartments in Adolescents with Anorexia Nervosa

Kooh, Sang Whay; Noriega, E.; Leslie, Karen; Müller, C.; Harrison, Joan E.

doi:10.1007/978-1-4899-1268-8_39

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Wong et al (2002) found that Hologic DXA has poor limits of agreement in comparison with the four-compartment model for body composition assessment in children. On the other hand, this technique has been frequently tested in paediatric subjects, including soft-tissue analysis (Chan, 1992;Ellis et al 1993;Faulkner et al 1993;Kooh et al 1993;Rico et al 1993;Skinner et al 2003), even in small infants and newborns (Venkataraman & Ahluwalia, 1992;Brunton et al 1993). It is considered a technique to measure body composition of potential use to the paediatric population (Goran, 1998).…”

Section: Discussionmentioning

confidence: 99%

Stunted children gain less lean body mass and more fat mass than their non-stunted counterparts: a prospective study

et al. 2004

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The aim of the present study was to analyse the changes in body composition of stunted children during a follow-up period and to test the hypothesis of a tendency to accumulate body fat as a consequence of undernutrition early in life. We selected fifty boys and girls aged 11 to 15, who were residents of slums in Sao Paulo, Brazil. Twenty were stunted (S) and thirty had normal stature (NS). The children's nutritional status and body composition were assessed through anthropometry and dual-energy X-ray absorptiometry, at the beginning of the present study and after 3 years, and changes in lean mass (LM and LM%) and fat mass (FM and FM%) were calculated. Stunted boys accumulated more body fat (FM%: S=1.62%, NS=-3.40%; P=0.003) and gained less lean mass (LM%: S=-1.46, NS=3.21%; P=0.004). Stunted girls gained less lean mass (S=7.87 kg, NS=11.96 kg; P=0.032) and had significantly higher values of FM% at follow-up when compared with their baseline values (P=0.008), whereas non-stunted girls had a non-significant difference in FM% over time (P=0.386). These findings are important to understand the factors involved in the increased prevalence of overweight and obesity among poor populations, which appear to be associated with hunger during infancy and/or childhood.

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Section: Discussionmentioning

confidence: 99%

Stunted children gain less lean body mass and more fat mass than their non-stunted counterparts: a prospective study

et al. 2004

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“…DXA is more accurate, with a coefficient of variation below 1%, and requires lower radiation exposure than other methods (22,23). Consequently, we measured the BMD of the lumbar spine using DXA in Japanese patients with anorexia nervosa, and then followed them to clarify how BMD is affected by the degree of weight gain or resumption of menses.…”

Section: Introductionmentioning

confidence: 99%

The importance of body weight history in the occurrence and recovery of osteoporosis in patients with anorexia nervosa: evaluation by dual X-ray absorptiometry and bone metabolic markers

Hotta

Shibasaki

Sato

et al. 1998

European Journal of Endocrinology

117

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In order to investigate the risk factors, pathogenesis and natural course of the osteoporosis frequently seen in anorexia nervosa, we measured the bone mineral density (BMD) of the lumbar spine using dual X-ray absorptiometry in 51 Japanese female patients with anorexia nervosa, and followed the change in BMD of 29 patients for 11 to 46 months. We also evaluated the serum osteocalcin and the urinary CrossLaps, degradation products of collagen I, in 103 samples obtained from 51 patients. There was a significant correlation between the spinal BMD and the duration of emaciation below a body mass index (BMI) of 15 kg/m 2 (r ¼ ¹0.652, P < 0.0001) and 16 kg/m 2 (r ¼ ¹0.647, P < 0.0001). The increase in BMD per year in the 29 patients significantly correlated with the BMI at the time of entry of each follow-up period (r ¼ 0.712, P < 0.0001). The critical BMI for a positive increase in BMD was 16.4 Ϯ 0.3 kg/m 2 (mean Ϯ S.E.M.). The serum osteocalcin declined, while the urinary CrossLaps increased in proportion to a decrease in BMI. Both markers were normalized in patients whose BMI was between 16.4 and 18.5 kg/m 2 . The ratio of urinary CrossLaps to serum osteocalcin correlated with BMI (r ¼ ¹0.664, P < 0.0001).We conclude that the body weight history is the most important predictor of the presence of osteoporosis as well as of recovery. The BMD of patients does not increase to the normal range even several years after the recovery from this disorder, and they remain a high-risk group for osteoporosis in the future.

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“…Restoration of menses has been shown to significantly improve BMD [24], but full recovery may not be attained [26]. Weight gain has been shown to lead to recovery of bone mineral deficits in some [5,7,[26][27][28][29], but not all adolescent studies [14,[30][31][32][33]. These studies are reviewed extensively elsewhere [34].…”

Section: Accepted Manuscriptmentioning

confidence: 99%