Bone mass and bone modelling markers in hypertensive postmenopausal women

Abstract

Numerous phosphocalcium alterations associated with bone mineral density in hypertension have been described, but very few studies assess them. This study assesses bone mass in hypertensive postmenopausal women and the hypertension influence determining both calcium homeostasis and bone turnover markers. Blood and urine samples were analysed for calcium metabolism-related parameters. Densitometry studies were conducted in the lumbar spine (L2-L4). Hypertensive osteoporotic womenFselected from 82 women, with 22% osteoporosis prevalence, similar to the rate for the same age in the Spanish populationFhad significantly higher levels of body mass index (29 7 4 vs 26 7 4, P ¼ 0.019), calciuria (293 7 146 vs 210 7 116 mg/ 24 h, P ¼ 0.023) and calcium/creatinine ratio (0.33 7 0.2 vs 0.22 7 0.1 P ¼ 0.003) vs hypertensive nonosteoporotic women. No relation was found between systolic and diastolic blood pressure with bone mass. However, there was a negative osteocalcin correlation (r ¼ À0.386, P ¼ 0.0001, and r ¼ À0.242, P ¼ 0.033). Calciuria is associated with bone mass decrease in hypertensive women, and there is no relation between bone mass and blood pressure.

Reparação de defeitos ósseos em fêmures de ratos machos e fêmeas espontaneamente hipertensos: estudo histológico e histométrico

“…Some bone pathologies may be aggravated in hypertensive individuals due to their pattern of calcium regulation, which induces bone loss in hypertensive human individuals [1][2][3] as well as in spontaneously hypertensive rats (SHR) [4][5][6] . Thus, bone mineral density (BMD) is reduced in hypertensive humans [1][2][3] and in SHR [4][5][6] , when compared to normal normotensive controls.…”

Bone healing of mandibular critical-size defects in spontaneously hypertensive rats

“…Hypercalciuria and a higher calcium/creatinine ratio are found mainly in osteoporotic groups, but bone mineral density (BMD) and osteoporosis percentages in the postmenopausal period are similar between hypertensive and normotensive women. 3 Urinary calcium excretion is inversely correlated to BMD, whereas serum total and ionized calcium levels in hypertensive women are not different from those observed in normotensive women. 4,5 Diastolic hypertensive men have reduced bone mineral content when compared with normotensive subjects.…”

Ação local do alendronato sódico na reparação óssea de ratos espontaneamente hipertensos (SHR)

“…The systemic arterial hypertension consists of a disease related to important bone alterations, that can cause mainly the decrease of the bone mineral density 1,4,[15][16][17] . Some authors suggest the existence of positive relationship between the alterations of the factors of regulation of the calcium and the tendency to the bone loss in hypertensive individuals 18,19 .…”