Bone Mass After Long-Term Euthyroidism in Former Hyperthyroid Women Treated with 131I

Serraclara, Alicia; Sarabia, Francisco; Hawkins, Federico

doi:10.1385/jcd:4:3:249

Cited by 13 publications

(13 citation statements)

References 30 publications

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“…This was demonstrated by, for example, Campos-Pastor et al (12) and Serraclara et al (27), who both reported a larger bone loss in postmenopausal than premenopausal women with hyperthyroidism.…”

Section: Hyperthyroidism and Bone-mentioning

confidence: 83%

Hyperthyroidism, Bone Mineral, and Fracture Risk—A Meta-Analysis

Vestergaard

Mosekilde

2003

Thyroid

260

161

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This study examined changes in bone mineral and fracture risk after treatment for hyperthyroidism in a meta-analysis. The PubMed and EMBASE were searched using the MESH terms "hyperthyroidism," "bone mineral density" (BMD), and "fracture," resulting in retrieval of 289 references. Twenty references describing BMD and five describing fracture risk were included in the meta-analysis. BMD was significantly decreased in patients with untreated hyperthyroidism. Upon treatment BMD increased significantly and reversed to normal levels with a temporary increase above normal levels 1-4 years after diagnosis. The risk of hip fractures increased significantly with age at diagnosis of hyperthyroidism. The hip fracture risk after diagnosis predicted from studies on BMD was close to that observed in clinical studies comparing fracture risk in hyperthyroid patients with normal controls. Thus BMD is significantly decreased and fracture risk increased in untreated hyperthyroidism. Upon normalization of the hyperthyroid state BMD return to normal even though no specific antiosteoporotic measures are taken other than normalizing the hyperthyroid state.

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Section: Hyperthyroidism and Bone-mentioning

confidence: 83%

Hyperthyroidism, Bone Mineral, and Fracture Risk—A Meta-Analysis

Vestergaard

Mosekilde

2003

Thyroid

260

161

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“…Variable degrees of bone mass recovery after treatment of hyperthyroidism have been observed in some longitudinal (Linde & Friis, 1979;Diamond et al, 1994;Obermayer-Pietsch et al, 2000) or cross-sectional studies (Nielsen et al, 1979;Grant et al, 1995;Langdahl et al, 1996;Jodar et al, 1997;Serraclara et al, 2001). Natural symptomatic hyperthyroidism apparently affects the patients for a limited period of time before its diagnosis and treatment because the patients seek medical assistance for their symptoms; the other conditions, usually of lower intensity, may go on for long periods of time before they are recognized.…”

Section: Discussionmentioning

confidence: 99%

Bone mineral density in hyperthyroidism

Karga¹,

Papapetrou²,

Korakovouni³

et al. 2004

Clinical Endocrinology

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Overt symptomatic hyperthyroidism is associated with decreased BMD during the first 3 years after diagnosis and treatment of the disease. After this interval, former hyperthyroid women have a Z-score near zero and not different from women without a history of the disease, apparently because of recovery of the bone density lost early during the course of the disease. Symptomatic hyperthyroidism does not seem to be a cause of long-lasting osteoporosis, and the age of the patient during the first episode is irrelevant.

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“…Numerous studies have evaluated BMD after the successful treatment of hyperthyroidism and reported a significant, though incomplete, recovery of bone density with effective antithyroid treatment within the first years after initiation of therapy [54, 56, 59–66]. Despite significant increases in BMD at the lumbar spine, femoral neck, and distal radius after 9–12 months of antithyroid therapy, bone density remained 5–16% lower than controls at 18–24 months of followup [50, 67].…”

Section: Reversibility Of Hyperthyroidism-induced Bone Loss With Tmentioning

confidence: 99%

Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density

Gorka

Taylor-Gjevre

Arnason

2013

International Journal of Endocrinology

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In 1891, Von Recklinghausen first established the association between the development of osteoporosis in the presence of overt hyperthyroidism. Subsequent reports have demonstrated that BMD loss is common in frank hyperthyroidism, and, to a lesser extent, in subclinical presentations. With the introduction of antithyroid medication in the 1940s to control biochemical hyperthyroidism, the accompanying bone disease became less clinically apparent as hyperthyroidism was more successfully treated medically. Consequently, the impact of the above normal thyroid hormones in the pathogenesis of osteoporosis may be presently underrecognized due to the widespread effective treatments. This review aims to present the current knowledge of the consequences of hyperthyroidism on bone metabolism. The vast number of recent papers touching on this topic highlights the recognized impact of this common medical condition on bone health. Our focus in this review was to search for answers to the following questions. What is the mechanisms of action of thyroid hormones on bone metabolism? What are the clinical consequences of hyperthyroidism on BMD and fracture risk? What differences are there between men and women with thyroid disease and how does menopause change the clinical outcomes? Lastly, we report how different treatments for hyperthyroidism benefit thyroid hormone-induced osteoporosis.

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Bone Mass After Long-Term Euthyroidism in Former Hyperthyroid Women Treated with 131I

Cited by 13 publications

References 30 publications

Hyperthyroidism, Bone Mineral, and Fracture Risk—A Meta-Analysis

Hyperthyroidism, Bone Mineral, and Fracture Risk—A Meta-Analysis

Bone mineral density in hyperthyroidism

Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density

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