Bone marrow WT1 levels in patients with myeloid neoplasms treated with 5‐azacytidine: Identification of responding patients

Santaliestra, Marta; Garrido, Ana; Carricondo, Maite; Bussaglia, Elena; Pratcorona, Marta; Blanco, María Laura; Gich, Ignasi; Hoyos, Montserrat; Esquirol, Albert; García‐Cadenas, Irene; Brunet, Salut; Martino, Rodrigo; Sierra, Jorge; Nomdedéu, Josep F.

doi:10.1111/ejh.13275

Cited by 9 publications

(1 citation statement)

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“…1 Preliminary data suggest that MRD positivity after non-intensive induction is also associated with poor outcomes. [60][61][62][63] 2. Selecting the technique, material, and appropriate time points for MRD assessment MFC MRD has been established as prognostic factor after induction chemotherapy on BM.…”

Section: Mrd As Prognostic Risk Factormentioning

confidence: 99%

2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

Heuser

Freeman

Ossenkoppele

et al. 2021

Blood

379

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Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML) that is used for prognostic, predictive, monitoring, and efficacy-response assessments. The European LeukemiaNet (ELN) MRD working party evaluates standardization and harmonization of MRD in an ongoing manner and has updated the 2018 ELN MRD recommendations based on significant developments in the field. New and revised recommendations were established during in-person and online meetings, and a two-stage Delphi poll was conducted to optimize consensus. All recommendations are graded by levels of evidence and agreement. Major changes include technical specifications for next generation sequencing (NGS)-based MRD testing and integrative assessments of MRD irrespective of technology. Other topics include use of MRD as a prognostic and surrogate endpoint for drug testing; selection of the technique, material, and appropriate time points for MRD assessment; and clinical implications of MRD assessment. In addition to technical recommendations for flow- and molecular- MRD analysis, we provide MRD thresholds and define MRD response, and detail how MRD results should be reported and combined if several techniques are used. MRD assessment in AML is complex and clinically relevant, and standardized approaches to application, interpretation, technical conduct, and reporting are of critical importance.

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