Bone Marrow Transplantation Between Mixed Leukocyte Culture Reactive Siblings

Thirty-three patients with acute leukemia (15 with lymphoblastic leukemia and 18 with myeloblastic leukemia) were entered into a program of high-dose radiochemotherapy followed by allogeneic bone-marrow transplantation. These patients were in various clinical stages of disease. Of 10 in complete hematologic remission at the time of transplantation, seven were alive without maintenance therapy at the time of evaluation, eight to 35 months after grafting; one was in relapse. Of 11 who received transplants during partial remission, six were in remission without further treatment eight to 33 months after transplantation. In 12 the disease was refractory to chemotherapy when preparation for transplantation was started, and only one of them was alive and free of disease after 10 months. Recurrent leukemia, graft-versus-host disease, viral pneumonia, and early therapy-related toxicity were the major causes of failure. High-dose chemotherapy and total-body irradiation followed by allogeneic marrow transplantation performed during complete or partial remission can produce long-term remission of acute leukemia.

show abstract

Bone Marrow Transplantation Between Mixed Leukocyte Culture Reactive Siblings

Cited by 4 publications

References 0 publications

Histocompatibility Testing for Clinical Bone Marrow Transplantation and Prospects for Identification of Donors Other than HLA Genotypically Identical Siblings

Histocompatibility Testing for Clinical Bone Marrow Transplantation and Prospects for Identification of Donors Other than HLA Genotypically Identical Siblings

Clinical Side Effects of Immunosuppressive Therapy (as Demonstrated in Bone Marrow Graft Recipients)

Bone-Marrow Ablation and Allogeneic Marrow Transplantation in Acute Leukemia

Contact Info

Product

Resources

About