Bone Marrow Stem Cells‐Seeded Polyethylene Terephthalate Scaffold in Repair and Regeneration of Rabbit Achilles Tendon

Cai, Jiangyu; Yang, Yimeng; Ai, Chengchong; Jin, Wenhe; Sheng, Dandan; Chen, Shiyi

doi:10.1111/aor.13298

Cited by 18 publications

(16 citation statements)

References 27 publications

(34 reference statements)

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“…Animal species used comprise small (rats [54, [106][107][108][109][110][111][112][113][114][115][116][117][118] and rabbits [119][120][121][122]) and large animals (dogs [123][124][125][126], sheep [127][128][129], and horses [130][131][132][133][134][135][136][137][138][139][140][141]).…”

Section: In Vivo Modelsmentioning

confidence: 99%

“…Several in vivo studies have investigated the effect of MSC treatment on tendon ECM composition and structure, as well as on tendon biomechanical parameters. In most of these studies, including an equine large animal study with a follow-up of 45 weeks, the ECM composition was improved by BMSC and ASC treatment, with higher expression of collagen I on gene and/or protein level [106,114,120,122,140]. Collagen III expression was found to be decreased after ASC implantation [110,125,126] but increased after BMSC implantation [106,122].…”

Section: In Vivo Evidencementioning

confidence: 99%

“…In most of these studies, including an equine large animal study with a follow-up of 45 weeks, the ECM composition was improved by BMSC and ASC treatment, with higher expression of collagen I on gene and/or protein level [106,114,120,122,140]. Collagen III expression was found to be decreased after ASC implantation [110,125,126] but increased after BMSC implantation [106,122]. Tenascin-C and decorin were found to be increased following BMSC and ASC treatment [112,114,140], and glycosaminoglycans were decreased after BMSC treatment [141].…”

Section: In Vivo Evidencementioning

confidence: 99%

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Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

Burk¹

2019

Tendons

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Multipotent mesenchymal stromal cells (MSCs) are a promising therapeutic tool to treat tendon disease. Aiming to establish successful treatment approaches and to fully exploit the regenerative potential of the MSC, it is crucial to understand their mechanisms of action. However, these can be multifaceted and strongly context-sensitive and are still not well-understood in the context of tendon disease. This review aims to shed light on the different possible mechanisms, including engraftment, tenogenic differentiation, extracellular matrix synthesis and remodeling, immunomodulation, pro-angiogenetic effects, trophic support, and protection of resident tendon cells. Evidence from experimental and clinical (veterinary) case studies was compiled and interpreted in conjunction with the respective in vitro and animal models used.

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Section: In Vivo Modelsmentioning

confidence: 99%

Section: In Vivo Evidencementioning

confidence: 99%

Section: In Vivo Evidencementioning

confidence: 99%

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Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

Burk¹

2019

Tendons

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“…Jiangyu Cai et al of Fudan University, Shanghai, China, evaluated the effect of bone marrow stem cells (BMSCs)‐seeded polyethylene terephthalate (PET) scaffold for Achilles tendon repair in a rabbit model. Sixteen mature New Zealand rabbits underwent surgery to establish a 2‐cm Achilles tendon defect model.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Artificial Organs 2018: A Year in Review

Malchesky¹

2019

Artificial Organs

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In this Editor's Review, articles published in 2018 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed special issues this year included contributions from the 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, and the 25th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Marvin Slepian. Additionally, many editorials highlighted the worldwide survival differences in hemodialysis and perspectives on mechanical circulatory support and stem cell therapies for cardiac support. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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“…The fabrication of intraoral appliances for prevention of self-inflicted soft tissue injury has been reported in special needs patients (7-9) and in those with habitual biting of the oral mucosa (10,11). Polyethylene terephthalate has been used in the fields of medicine (12,13) and dentistry, particularly orthodontics (14). This material has been used for the fabrication of orthodontic aligners, mouth guards, and splints (15,16).…”

Section: Introductionmentioning

confidence: 99%