“…In unselected series of patients with prostatic cancer, the frequency of bone metastases detected by bone scintigraphy varies from 30% to 51% (22). Since the sinusoid of the red bone marrow is the site for metastatic spread and the adult red bone marrow is located in the axial skeleton, bone marrow metastases are usually located within these areas (20,32). In hematologic disease, chronic anemia, malignancy, chemotherapy, or irradiation, the red marrow may extend into the extremities (14,20,24,27,29,31), thus increasing the risk of peripheral metastases.…”