Bone Marrow, Peripheral Blood, or Umbilical Cord Blood: Does the Source of Allogeneic Hematopoietic Progenitor Cells Matter?

Seitz, Rainer; Hilger, A.; Heiden, M.

doi:10.4172/2155-9864.s1-007

Cited by 3 publications

(3 citation statements)

References 26 publications

(24 reference statements)

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“…Apheresis as a form of donation first appears in our data in 1999, so we run our regressions using just the observations for those individuals donating after 1999. Although apheresis is significantly less burdensome for the donor, some authors still consider bone marrow donation via aspiration preferable (Seitz et al, 2012.) Yet, because the financial and physical barriers to apheresis are lower than for aspiration, one might expect an increase in this type of donation, in particular from donors on the margin between donating and not donating.…”

Section: Bone Marrow Donations: Main Resultsmentioning

confidence: 99%

Removing financial barriers to organ and bone marrow donation: The effect of leave and tax legislation in the U.S.

Lacetera

Macis

Stith

2014

Journal of Health Economics

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Standard-Nutzungsbedingungen:Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden.Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen.Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. www.econstor.eu The Institute for the Study of Labor (IZA) in Bonn is a local and virtual international research center and a place of communication between science, politics and business. IZA is an independent nonprofit organization supported by Deutsche Post Foundation. The center is associated with the University of Bonn and offers a stimulating research environment through its international network, workshops and conferences, data service, project support, research visits and doctoral program. IZA engages in (i) original and internationally competitive research in all fields of labor economics, (ii) development of policy concepts, and (iii) dissemination of research results and concepts to the interested public. Terms of use: Documents in D I S C U S S I O N P A P E R S E R I E SIZA Discussion Papers often represent preliminary work and are circulated to encourage discussion. Citation of such a paper should account for its provisional character. A revised version may be available directly from the author. In an attempt to alleviate the shortfall in organs and bone marrow available for transplants, many U.S. states passed legislation providing leave to organ and bone marrow donors and/or tax benefits for live and deceased organ and bone marrow donations and to employers of donors. We exploit cross-state variation in the timing and passage of such legislation to analyze its impact on organ donations by living and deceased persons, on measures of the quality of the organs transplanted, and on the number of bone marrow donations. We find that these provisions did not have a significant impact on the quantity of organs donated. The leave legislation, however, did have a positive impact on bone marrow donations. We also find some evidence of a positive impact on the quality of organ transplants, measured by post-transplant survival rates. Our results suggest that these types of legislation work for moderately invasive procedures such as bone marrow donation, but may be too low for organ donation, which is riskier and more burdensome to the donor.JEL Classification: D64, H41, I12, J18, K32

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Section: Bone Marrow Donations: Main Resultsmentioning

confidence: 99%

Removing financial barriers to organ and bone marrow donation: The effect of leave and tax legislation in the U.S.

Lacetera

Macis

Stith

2014

Journal of Health Economics

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“…Stem cell transplants and cord blood transplants are substitutes for one another, but they are not perfectly substitutable. Cord blood transplants have three important advantages over stem cell transplants (Seitz et al, 2012). First, if a matching cord blood deposit exists, then it is usually available much more quickly than a transplant from an adult donor.…”

Section: Some Medical Backgroundmentioning

confidence: 99%

Saving lives with stem cell transplants

2015

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Blood stem cell transplants can be life-saving for some patients, but the chances of finding a matching donor are small unless a large number of potential donors are evaluated. Many nations maintain large registries of potential donors who have offered to donate stem cells if they are the best available match for a patient needing a transplant. An alternative source of stem cells, umbilical cord blood, is stored in banks. Everyone faces a small probability of needing a transplant which will increase their likelihood of survival. The registries and cord blood banks are thus an interesting example of a pure public good with widely dispersed benefits. This paper explores the gains in survival probability that arise from increased registry and bank sizes and uses value of statistical life methods to estimate benefits and compare them to costs. Our results suggest that for the United States and for the world as a whole, the sum of marginal benefits of an increase in either the adult registry or the cord blood bank exceeds marginal costs. However, marginal benefit-cost ratios for the adult registry are much greater than those for the cord blood banks, which suggests that to the extent that these two sources of life saving compete for public funds it may be preferable to prioritize expansion of the adult registry over cord blood banks.

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“…MSCs can be isolated from various sources of adult tissues, including bone marrow, adipocyte cells, umbilical cord, and peripheral blood. [4] Stem cells involve in bone remodeling as evidenced by RANKL expression in MSCs cultures or stromal cells and functionally contribute to osteoclastogenesis in vitro. MSCs populations also play an indirect role as a progenitor source of osteoblasts which is responsible for anabolic from homeostatic balance and regulate osteoclastogenesis through RANKL and OPG expression.…”

Section: Introductionmentioning

confidence: 99%

The Significant Effect of Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells in Histological Improvement of Cartilage Defect in Wistar Rats

Soetjahjo¹,

Hidayat²,

Sujuti³

et al. 2018

Turk J Immunol

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Introduction: Mesenchymal stem cells are multipotent cells present in multiple tissues that have potential for future disease treatment including cartilage damage. This study was aimed to investigate the effect of conditioned medium of umbilical cord stem cells in improving the histological conditions of damaged cartilage in rats. Materials and Methods: Twenty-four of 3-month old male rats that were divided into 6 groups (3 control groups and 3 treatment groups) with different evaluation time (month 2, month 3, and month 4). Treatment in each group was repeated 5 times. The cartilage defect was induced manually and mechanically at the medial condyle of rats' right femur using a Kirschner Wire (D=1.0 mm; h=1.0 mm). The umbilical cord stem cell cultures were obtained from pregnant rats (19 days). Rats in treatment groups were injected with mesenchymal stem cell-conditioned medium (1 mL/kg BW) 5 times with interval a week after cartilage defect. Histopathological examination of chondrocytes formation and fibrosis tissues was done through Haematoxylin Eosin staining. Data were assessed with O'driscoll scoring and analyzed statistically using Kruskal-Wallis test with SPSS 16.0 software statistically using Kruskal-Wallis Test with SPSS 16.0 software. Results: The conditioned medium of umbilical cord mesenchymal stem cells was able to repair the damage in cartilage tissue of Wistar rats. It is indicated by the higher score of nature of predominant tissue, surface regularity, structural integrity, bonding with adjacent cartilage and the level of new tissue formed in the treatment group compared to control group. Statistically, there is a significant difference of bonding to the adjacent cartilage score (0.028, p<0.05) in treatment group than in control group. There is no significant difference of nature of the predominant tissue score (0.064, p>0.05), surface regularity (0.064, p>0.05), structural integrity (0.075, p>0.05), level of newly formed tissue (0.088, p>0.05). Conclusion: The supplementation of conditioned medium of umbilical cord mesenchymal stem cell ameliorate the repair of damaged cartilage.

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Bone Marrow, Peripheral Blood, or Umbilical Cord Blood: Does the Source of Allogeneic Hematopoietic Progenitor Cells Matter?

Cited by 3 publications

References 26 publications

Removing financial barriers to organ and bone marrow donation: The effect of leave and tax legislation in the U.S.

Removing financial barriers to organ and bone marrow donation: The effect of leave and tax legislation in the U.S.

Saving lives with stem cell transplants

The Significant Effect of Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells in Histological Improvement of Cartilage Defect in Wistar Rats

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