Bone marrow necrosis associated with a Mucor infection

Caraveo, Juan; Trowbridge, Arthur A.; Amaral, Barbara; Green, Jacob B.; Cain, Phillip T.; Hurley, Douglas L.

doi:10.1016/0002-9343(77)90838-5

Cited by 33 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…cause many diseases, and other members of the Mucorales family act as opportunistic human pathogens (27). Mucorales infections are observed in a variety of disease states that cause immunosuppression associated with leukemia (28), aplastic anemia (29), organ or bone marrow transplantation (28), renal disease (30), and asthma (31). Therefore, new effective drugs for mucormycosis are required immediately.…”

Section: Structural Characterization Of Oligosaccharides Of Ngls-mentioning

confidence: 99%

Newly Discovered Neutral Glycosphingolipids in Aureobasidin A-resistant Zygomycetes

Aoki

Uchiyama

Yamauchi

et al. 2004

Journal of Biological Chemistry

View full text Add to dashboard Cite

We found for the first time that Zygomycetes species showed resistance to Aureobasidin A, an antifungal agent. A novel family of neutral glycosphingolipids (GSLs) was found in these fungi and isolated from Mucor hiemalis, which is a typical Zygomycetes species. Their structures were completely determined by compositional sugar, fatty acid, and sphingoid analyses, methylation analysis, matrix-assisted laser desorption ionization time-of-flight/mass spectrometry, and 1 H NMR spectroscopy. They were as follows: Gal␤1-6Gal␤1-1Cer (CDS), Gal␣1-6Gal␤1-6Gal␤1-1Cer (CTS), Gal␣1-6Gal␣1-6Gal␤1-6Gal␤1-1Cer (CTeS), and Gal␣1-6Gal␣1-6Gal␣1-6Gal␤1-6Gal␤1-1Cer (CPS). The ceramide moieties of these GSLs consist of 24:0, 25:0, and 26:0 2-hydroxy acids as major fatty acids and 4-hydroxyoctadecasphinganine (phytosphingosine) as the sole sphingoid. However, the glycosylinositolphosphoceramide families that are the major GSLs components in fungi were not detected in Zygomycetes at all. This seems to be the reason that Aureobasidin A is not effective for Zygomycetes as an antifungal agent. Our results indicate that the biosynthetic pathway for GSLs in Zygomycetes is significantly different from those in other fungi and suggest that any inhibitor of this pathway may be effective for mucormycosis, which is a serious pathogenic disease for humans.

show abstract

Section: Structural Characterization Of Oligosaccharides Of Ngls-mentioning

confidence: 99%

Newly Discovered Neutral Glycosphingolipids in Aureobasidin A-resistant Zygomycetes

Aoki

Uchiyama

Yamauchi

et al. 2004

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…13,23,45,62,95 Case reports of mucormycosis 96 and Q fever 97 have been described in association with BMN in the absence of any underlying malignancy. Furthermore, Mycobacterium tuberculosis 61,98 has been described as a responsible agent.…”

Section: Underlying Disease Associationsmentioning

confidence: 99%

“…14 The aspirate can smear very unevenly. 96 Microscopy shows a background of amorphous extracellular eosinophilic proteinaceous material that surrounds cells that desintegrate 8 (Fig. 1).…”

Section: Cytologymentioning

confidence: 99%

Bone marrow necrosis

Janssens

Offner

Hove

2000

Cancer

118

View full text Add to dashboard Cite

“…Malignancy, especially hemopoietic neoplasia, is the most common cause of BMN [5][6][7][8][9][10][11][12][13][14][15]. Sickle cell disease (SCD), infections, sepsis, and drug ingestion are nonmalignant causes of BMN [16][17][18][19][20][21][22][23][24][25]. Some cytokines and new antineoplastic drugs, such as interferon alpha, G-CSF, ATRA, and fludarabine, which are commonly used drugs in hematology-oncology practice, may cause BMN [26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature

et al. 2002

View full text Add to dashboard Cite

Bone marrow necrosis (BMN) is a relatively uncommon clinicopathologic entity. The etiology is diverse, and malignancy, especially hematopoietic in origin, is the most common underlying disease of BMN. In this retrospective analysis, cases with BMN were re-evaluated for etiology, histopathologic details, and clinical manifestations. In the last 8 years, 23 cases of BMN were detected among the 1,083 bone marrow (BM) biopsies, and the prevalence was found to be 2.2%. Three of these 23 cases with BMN were children, and 20 cases were in adults. Sixteen of these cases (80%) had underlying malignant disease, and four (20%) had nonmalignant disease. Among the malignant cases, three cases had acute myeloblastic leukemia (AML), four had relapsed Hodgkin's disease (R-HD), one had acute lymphoblastic leukemia (ALL), two had chronic myelocytic leukemia (CML), two had non-Hodgkin's lymphoma (NHL), three had disseminated intravascular coagulation (DIC) associated with metastatic solid tumor, and one had myelodysplastic syndrome/myeloproliferative syndrome (MDS/MPS). Among the nonmalignant cases, two had tuberculosis infection, one had anti-phospholipid syndrome (APS), and one had a history of drug ingestion. The most common symptoms were bone pain, fever, fatigue, and jaundice. The most common laboratory findings were variable and associated with underlying disease, but anemia, leukopenia, thrombocytopenia, and high LDH and alkaline phosphatase levels were detected in the majority of the cases, as was also seen in other series. BMN was graded according to the extent of necrosis in the BM biopsy, and necrosis was extensive in 12 cases, moderate in five cases, and mild in three cases. Increased reticulin was found in 16 cases; four cases had severe, eight had moderate, and four had mild fibrosis, and this was found to be an interesting accompanying finding in BMN. In conclusion malignancy is the most common cause of BMN but some nonmalignant conditions such as tuberculosis and APS may be the underlying cause of BMN. Am.

show abstract

Bone marrow necrosis associated with a Mucor infection

Cited by 33 publications

References 11 publications

Newly Discovered Neutral Glycosphingolipids in Aureobasidin A-resistant Zygomycetes

Newly Discovered Neutral Glycosphingolipids in Aureobasidin A-resistant Zygomycetes

Bone marrow necrosis

Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature

Contact Info

Product

Resources

About