Bone Marrow Morphologic Findings in Patients with Human Immunodeficiency Virus (HIV) Infection

Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis

“…By choosing to establish the diagnosis of haemophagocytic syndrome using these criteria we intended to do better than defining the cases only on the basis of haemophagocytosis. Indeed, we think that evidence of active haemophagocytosis in bone marrow is not sufficient to establish the diagnosis of haemophagocytic syndrome because it is probable that HIV itself can cause various degrees of histiocytic reaction without any associated disease [12,30,31]. However, the validity of such an adaptation of the original criteria cannot be defined.…”

Progenitor Cell Types in HIV-1 Infection: Bioactivity and Emerging Targets for Treatment

“…Certain bone marrow abnormalities associated with HIV infection have been identified clinically; with necrotic bodies and dysplasic lesions having been observed at autopsy, in conjunction with reduced iron stores, hypercellularity, and increased incidence of lmphomas [19][20][21]. It has been suggested that these bone marrow abnormalities may in part account for the incomplete restoration of immune function after antiretroviral therapy [21].…”