Bone marrow mononuclear cell implantation in myocardial laser channels in the ischemic heart disease surgery. Long-term results

Abstract

Abstract. Background: The problem of incomplete myocardial revascularization for diffuse and distal lesions of the myocardium is still relevant. We assessed the clinical and instrumental long-term results of autologous bone marrow cell (BMC) implantation in laser channels in ischemic heart disease with diffuse and distal coronary disease. 35 coronary heart disease (CHD) patients with diffuse and distal coronary disease during coronary artery bypass grafting (CABG) underwent BMC implantation in laser channels. The control group consisted of 29 patients. All patients in this group underwent only CABG. Clinical and instrumental assessment of the method's effect was carried out at two weeks, six months, and six years after surgery. Indirect revascularization showed more significant decreasing of the functional class (FC) New York Heart Association (NYHA), myocardial perfusion and contractility improvement. Autologous BMC implantation in laser channels is an effective method of CHD surgical treatment if it is impossible to perform direct myocardial revascularization. The indirect revascularization effect is formed in the first six months after surgery and remains at the same level for six years.

Transmiocardial laser revascularization in combination with bone marrow cells implantation in the ischemic heart disease surgery: long-term results

“…First results of this study was reported in Proceedings of the XXV Conference on High-Energy Processes in Condensed Matter (HEPCM 2017): Dedicated to the 60th anniversary of the Khristianovich Institute of Theoretical and Applied Mechanics Siberian branch of Russian Academy of Sciences (5-9 June 2017, Novosibirsk, Russia) [16].…”