Bone Marrow Mesenchymal Stem Cells Inhibit the Function of Dendritic Cells by Secreting Galectin-1

Zhang, Yue; Ge, Xiahui; Guo, Xuejun; Guan, Sibin; Li, Xiaoming; Gu, Wen; Xu, Weiguo

doi:10.1155/2017/3248605

Cited by 29 publications

(24 citation statements)

References 34 publications

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“…A recent study reports that MSCs secrete Galectin-1 and the authors postulate that this factor is able to inhibit dendritic cell function [ 25 ]. Furthermore, they detected increased Gal-1, IL-10, and IL-12 concentrations in supernatants from the co-culture system.…”

Section: Discussionmentioning

confidence: 99%

Effects of Jaw Periosteal Cells on Dendritic Cell Maturation

Dai

Rottau

Köhler

et al. 2018

JCM

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Clinical application of tissue engineering products requires the exclusion of immune responses after implantation. We used jaw periosteal cells (JPCs) as a suitable stem cell source and analyzed herein the effects of JPCs on dendritic cell maturation after co-culturing of both cell types. Peripheral blood mononuclear cells (PBMCs) were differentiated to dendritic cells (DCs) by the addition of differentiation cocktails for 7 days in co-culture with undifferentiated and osteogenically induced JPCs. The effects of JPCs on DC maturation were analyzed at the beginning (day 7), in the middle (day 14), and at the end (day 21) of the osteogenesis process. We detected significantly lower DC numbers after co-culturing with JPCs that have previously been left untreated or osteogenically differentiated for 7, 14, and 21 days. Using gene expression analyses, significantly lower IL-12p35 and -p40 and pro-inflammatory cytokine (IFN-γ and TNF-α) levels were detected, whereas IL-8 mRNA levels were significantly higher in DCs. Furthermore, osteogenic media conditions enhanced significantly IL-10 gene expression. We concluded that undifferentiated and osteogenically differentiated JPCs had an overall inhibiting influence on dendritic cell maturation. Further studies should clarify the underlaying mechanism in depth.

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Section: Discussionmentioning

confidence: 99%

Effects of Jaw Periosteal Cells on Dendritic Cell Maturation

Dai

Rottau

Köhler

et al. 2018

JCM

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“…TSG-6 also inhibits the maturation and function of DCs [164,165]. Zhang et al found that galectin-1 from MSCs stimulates the formation of a tolerance immunophenotype on DCs via regulating the MAPK signalling pathway in DCs, thereby inhibiting their function [166]. The immunomodulatory effects of MSC-derived factors have been observed during both the antigen recognition/ presentation stage and T cell activation stage of the immune response.…”

Section: Immunomodulatory Factorsmentioning

confidence: 99%

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Fan

Zhang

et al. 2020

Cell. Mol. Life Sci.

369

282

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Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of various diseases. The therapeutic potential of MSCs is attributed to complex cellular and molecular mechanisms of action including differentiation into multiple cell lineages and regulation of immune responses via immunomodulation. The plasticity of MSCs in immunomodulation allow these cells to exert different immune effects depending on different diseases. Understanding the biology of MSCs and their role in treatment is critical to determine their potential for various therapeutic applications and for the development of MSC-based regenerative medicine. This review summarizes the recent progress of particular mechanisms underlying the tissue regenerative properties and immunomodulatory effects of MSCs. We focused on discussing the functional roles of paracrine activities, direct cell-cell contact, mitochondrial transfer, and extracellular vesicles related to MSC-mediated effects on immune cell responses, cell survival, and regeneration. This will provide an overview of the current research on the rapid development of MSC-based therapies. Keywords Regenerative potential • Integration of MSCs • Immunomodulation • Soluble factors • Cell-cell contact • Mitochondrial transfer • Extracellular vesicles Abbreviations AHR Airway hyper-responsiveness Alix ALG-2-interacting protein X Ang-1 Angiopoietin-1 ASCs Adipose-derived stem cells BAX BCL-2-associated X protein BCL-2 B-cell lymphoma 2 CASP3 Caspase 3 CX43 Connexin 43 CXCR4 Chemokine receptor type 4 DC Dendritic cell Cellular and Molecular Life Sciences

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“…Firstly, galectin 1 seems to induce sorafenib-resistance in hepatocellular carcinoma through induction of αvβ3 integrin expression and activation of PI3K-Akt signaling [ 81 ]. Galectin-1 is also expressed in human AML bone marrow both by the leukemic cells and by stromal cells in the stem cell niches [ 82 , 83 ]. A recent study could not find any association between galectin expression in primary human AML cells and prognosis after conventional chemotherapy, but further studies are needed to clarify whether galectin-1 dependent chemoresistance is important for subsets of patients or for kinase inhibitory strategies.…”

Section: Summarizing and Concluding Commentsmentioning

confidence: 99%

The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia

Johansen

Brenner

Bartaula-Brevik

et al. 2018

IJMS

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Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion molecules. The primary AML cells express various integrins. These heterodimeric molecules containing an α and a β chain are cell surface molecules that bind extracellular matrix molecules, cell surface molecules and soluble mediators. The β3 integrin (ITGB3) chain can form heterodimers only with the two α chains αIIb and αV. These integrins are among the most promiscuous and bind to a large number of ligands, including extracellular matrix molecules, cell surface molecules and soluble mediators. Recent studies suggest that the two β3 integrins are important for leukemogenesis and chemosensitivity in human AML. Firstly, αIIb and β3 are both important for adhesion of AML cells to vitronectin and fibronectin. Secondly, β3 is important for the development of murine AML and also for the homing and maintenance of the proliferation for xenografted primary human AML cells, and for maintaining a stem cell transcriptional program. These last effects seem to be mediated through Syk kinase. The β3 expression seems to be regulated by HomeboxA9 (HoxA9) and HoxA10, and the increased β3 expression then activates spleen tyrosine kinase (Syk) and thereby contributes to cytokine hypersensitivity and activation of β2 integrins. Finally, high integrin αV/β3 expression is associated with an adverse prognosis in AML and decreased sensitivity to the kinase inhibitor sorafenib; this integrin can also be essential for osteopontin-induced sorafenib resistance in AML. In the present article, we review the experimental and clinical evidence for a role of β3 integrins for leukemogenesis and chemosensitivity in AML.

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Bone Marrow Mesenchymal Stem Cells Inhibit the Function of Dendritic Cells by Secreting Galectin-1

Cited by 29 publications

References 34 publications

Effects of Jaw Periosteal Cells on Dendritic Cell Maturation

Effects of Jaw Periosteal Cells on Dendritic Cell Maturation

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia

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