Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells

Nojszewska, N.; Idilli, O.; Sarkar, D.; Ahouiyek, Z.; Arroyo-Berdugo, Y.; Sandoval, C.; Amin-Anjum, MS; Bowers, S.; Greaves, D.; Saeed, L.; Khan, M.; Salti, S.; Al-Shami, S.; Topoglu, H.; Punzalan, JK; Farias, JG; Calle, Y.

doi:10.1016/j.ejcb.2023.151334

European Journal of Cell Biology

2023

DOI: 10.1016/j.ejcb.2023.151334

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Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells

N. Nojszewska,

O. Idilli,

D. Sarkar

et al.

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2023

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Cited by 2 publications

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Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells

Atiya,

Gorecki,

Garcia

et al. 2023

Biomolecules

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The ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell–cell adhesion and the acquisition of motile and stem-like phenotypes. A critical modulator of EMT in cancer cells is the stromal tumor microenvironment (TME), which can promote the acquisition of a mesenchymal phenotype through direct interaction with cancer cells or changes to the broader microenvironment. In this review, we will explore the role of stromal cells in modulating cancer cell EMT, with particular emphasis on the function of mesenchymal stromal/stem cells (MSCs) through the activation of EMT-inducing pathways, extra cellular matrix (ECM) remodeling, immune cell alteration, and metabolic rewiring.

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Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells

Atiya,

Gorecki,

Garcia

et al. 2023

Biomolecules

View full text Add to dashboard Cite

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Application of Quantitative Structure-Activity Relationships in the Prediction of New Compounds with Anti-Leukemic Activity

Sandoval,

Torrens,

Godoy

et al. 2023

IJMS

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Leukemia invades the bone marrow progressively and, through unknown mechanisms, outcompetes healthy hematopoiesis. Protein arginine methyltransferases 1 (PRMT1) are found in prokaryotes and eukaryotes cells. They are necessary for a number of biological processes and have been linked to several human diseases, including cancer. Small compounds that target PRMT1 have a significant impact on both functional research and clinical disease treatment. In fact, numerous PRMT1 inhibitors targeting the S-adenosyl-L-methionine binding region have been studied. Through topographical descriptors, quantitative structure-activity relationships (QSAR) were developed in order to identify the most effective PRMT1 inhibitors among 17 compounds. The model built using linear discriminant analysis allows us to accurately classify over 90% of the investigated active substances. Antileukemic activity is predicted using a multilinear regression analysis, and it can account for more than 56% of the variation. Both analyses are validated using an internal “leave some out” test. The developed model could be utilized in future preclinical experiments with novel drugs.

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Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells

Cited by 2 publications

References 80 publications

Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells

Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells

Application of Quantitative Structure-Activity Relationships in the Prediction of New Compounds with Anti-Leukemic Activity

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