Bone marrow iron score as an indicator for secondary iron overload in acute myeloid leukemia patients

Hoeks, Marlijn; Pol, Marit van der; Middelburg, Rutger A.; Evers, Dorothea; Kraaij, Marian van; Zwaginga, Jaap Jan

doi:10.1111/ejh.13145

Cited by 2 publications

(2 citation statements)

References 17 publications

(25 reference statements)

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“…The study found that the iron overload could promote the level of serum ferritin. Serum ferritin has been taken as an alternate marker for iron overload, while its feature as a protein in the acute phase reduces its specificity to examine iron overload under concurrent infection and/or inflammation 23 . Moreover, it is often found that elevated levels of serum ferritin prior to transplantation closely correlated with increased mortality within 5 years of the recipients receiving allo‐HSCT 24 .…”

Section: Discussionmentioning

confidence: 99%

“…Serum ferritin has been taken as an alternate marker for iron overload, while its feature as a protein in the acute phase reduces its specificity to examine iron overload under concurrent infection and/or inflammation. 23 Moreover, it is often found that elevated levels of serum ferritin prior to transplantation closely correlated with increased mortality within 5 years of the recipients receiving allo-HSCT. 24 Enhanced iron content in BM might be a sign of poor survival in allo-HSCT recipients and BM assessment before transplantation would be a promising diagnostic method of iron overload.…”

Section: Allo-hsct In An Iron-overloaded Mice Negatively Impacts Sumentioning

confidence: 99%

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Iron overload as a risk factor for poor graft function following allogeneic hematopoietic stem cell transplantation

Lin

Chen

et al. 2020

The Kaohsiung J of Med Scie

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Hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, iron overload is a frequent adverse effect of allo-HSCT and is associated with poor prognosis. In the present study, we investigated hematopoiesis in iron-overloaded mice and elucidated the effects of iron overload on the bone marrow (BM) microenvironment. Ironoverloaded BALB/C mice were generated by injecting 20 mg/mL saccharated iron oxide intraperitoneally. Hematoxylin-eosin staining was performed to evaluate the effects of an iron overload in mice. BM cells obtained from C57BL/6 mice were transplanted into irradiated BALB/C mice (whole-body irradiation of 4 Gy, twice with a 4-hours interval) by tail vein injection. Two weeks after allo-HSCT, the hematopoietic reconstitution capacity was evaluated in recipients by colony-forming assays. Histopathological examinations showed brown-stained granular deposits, irregularly arranged lymphocytes in the liver tissues, and blue-stained blocks in the BM collected from mice received injections of high-dose saccharated iron oxide (20 mg/mL). Ironoverloaded mice showed more platelets, higher-hemoglobin (HGB) concentration, fewer granulocyte-macrophage colony-forming units (CFU-GM), erythrocyte colonyforming units (CFU-E), and mixed granulocyte/erythrocyte/monocyte/megakaryocyte colony-forming units (CFU-mix) than healthy mice. Iron-overloaded recipients presented with reduced erythrocytes and HGB concentration in peripheral blood, along with decreased marrow stroma cells, CFU-GM, CFU-E, and CFU-mix relative to healthy recipients. Taken together, our findings demonstrate that iron overload might alter the number of red blood cells after transplantation in mice by destroying the

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Section: Discussionmentioning

confidence: 99%

Section: Allo-hsct In An Iron-overloaded Mice Negatively Impacts Sumentioning

confidence: 99%

Iron overload as a risk factor for poor graft function following allogeneic hematopoietic stem cell transplantation

Lin

Chen

et al. 2020

The Kaohsiung J of Med Scie

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Too much iron: A masked foe for leukemias

et al. 2020

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The role of iron in non-erythroid hematopoietic lineages and its implication in hemato-oncogenesis are still debated. Iron exerts an important role on hematopoietic stem cell transformation and on mature white blood cell differentiation. Iron acts experimentally as an oncogenic cofactor but its exact role in the transformation of the myelodysplastic syndrome into leukemia continues to be discussed. Body iron overload frequently develops mainly as the result of multiple erythrocyte transfusions in patients with leukemia or myelodysplastic syndrome, and, in the latter, as a result of increased ineffective erythropoiesis. Iron overload, especially through the deleterious effects of reactive oxygen species, leads to organ damage that likely impacts the global outcome of patients, especially after hematopoietic stem cell transplantation (HSCT). In these pathological settings (before and after HSCT), oral iron chelation should be considered whenever body iron overload has been firmly established, ideally by magnetic resonance imaging.

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Bone marrow iron score as an indicator for secondary iron overload in acute myeloid leukemia patients

Cited by 2 publications

References 17 publications

Iron overload as a risk factor for poor graft function following allogeneic hematopoietic stem cell transplantation

Iron overload as a risk factor for poor graft function following allogeneic hematopoietic stem cell transplantation

Too much iron: A masked foe for leukemias

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