Bone marrow involvement in systemic oxalosis presenting as pancytopenia and uremia – a first reported case in Malay population

Hassan, Mohd Nazri; Rahman, Wan Suriana Wan Abd; Zulkafli, Zefarina; Abdullah, Wan Zaidah; Aziz, Nor Azah Farhah Abd; Ibrahim, Iluni Hayati; Salleh, Sinari

doi:10.13070/rs.en.1.1129

Cited by 2 publications

(3 citation statements)

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“…The patient underwent bone marrow studies for evaluation of pancytopenia which led to the diagnosis of primary hyperoxaluria based on bone marrow biopsy findings. In general, bone marrow is an unusual route for the diagnosis of hyperoxaluria [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the case presented here, bone marrow oxalosis detected during the evaluation of pancytopenia led to the diagnosis of PH. There are few reports of bone marrow oxalosis associated with variable degrees of cytopenias, leukoerythroblastic reaction, and resistance to erythropoietin in English literature; some of them show marrow oxalosis [ 6 , 19 – 21 ]. Pancytopenia resulting from oxalate crystal deposition in bone marrow is a rare complication of PH.…”

Section: Discussionmentioning

confidence: 99%

“…Crystal deposition in kidneys is followed by deposits in bone marrow and other tissues. Diffuse replacement of marrow parenchyma by crystals leads to pancytopenia and a leukoerythroblastic reaction [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Hyperoxaluria Diagnosed Based on Bone Marrow Biopsy in Pancytopenic Adult with End Stage Renal Disease

Nematollahi

Mohammadizadeh

2015

Case Reports in Hematology

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Inborn errors of metabolism cause increase of metabolites in serum and their deposition in various organs including bone marrow. Primary hyperoxaluria (PH) is a rare inborn error in the pathway of glyoxylate metabolism which causes excessive oxalate production. The disease is characterized by widespread deposition of calcium oxalate (oxalosis) in multiple organs. Urinary tract including renal parenchyma is the initial site of deposition followed by extrarenal organs such as bone marrow. This case report introduces a 54-year-old woman with end stage renal disease presenting with debilitating fatigue and pancytopenia. The remarkable point in her past medical history was recurrent episodes of nephrolithiasis, urolithiasis, and urinary tract infection since the age of 5 years and resultant end stage renal disease in adulthood in the absence of appropriate medical evaluation and treatment. She had an unsuccessful renal transplantation with transplant failure. The patient underwent bone marrow biopsy for evaluation of pancytopenia. Microscopic study of bone marrow biopsy led to the diagnosis of primary hyperoxaluria.

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Section: Discussionmentioning

confidence: 99%