Bone marrow-inspired hydrogel/graphene composite scaffolds to support <i>in vitro</i> expansion of hematopoietic stem cells

Hong, Jing; Zhu, Zhanchi; Cui, Leisha; Wang, Zhaojun; Hao, Ying; Tian, Xiaopeng; Cheng, Guosheng

doi:10.1039/d3tb02448b

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02448b

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Bone marrow-inspired hydrogel/graphene composite scaffolds to support in vitro expansion of hematopoietic stem cells

Jing Hong,

Zhanchi Zhu,

Leisha Cui

et al.

Abstract: Hematopoietic stem cell (HSC) expansion offers a key strategy to address the source limitation and donor shortage of HSCs for the treatment of various blood disorders. Specific remodeling of complex...

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Are we ready to integrate 3D culture systems in acute myeloid leukemia and bone marrow microenvironment research?

Sharipol,

Frisch

2024

Front. Hematol.

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Acute myeloid leukemia (AML) is the most aggressive adult leukemia and results in a dismal 5-year survival rate of less than 30%. While research has primarily focused on identifying intrinsic mutations driving leukemogenesis, the role of the bone marrow microenvironment (BMME) in disease progression remains poorly understood. For this purpose, conventional 2D cultures inadequately replicate the complex BMME interactions crucial for the maintenance of normal hematopoiesis and leukemia pathogenesis. In recent years, 3D cultures or microphysiological systems (MPS), have emerged as promising tools for in vitro modeling of the human BMME. These approaches provide a promise for a more physiologically relevant platform for investigating the mechanistic underpinnings of AML interactions with BMME components, as well as exploring chemoresistance mechanisms and facilitating drug discovery efforts. This review discusses the considerations in biomaterials, biophysical, and biochemical factors to develop the BMME in vitro for AML studies, the state-of-the-art 3D models of the BMME, and the challenges and prospects of adopting MPS for AML research.

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Are we ready to integrate 3D culture systems in acute myeloid leukemia and bone marrow microenvironment research?

Sharipol,

Frisch

2024

Front. Hematol.

View full text Add to dashboard Cite

show abstract

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Bone marrow-inspired hydrogel/graphene composite scaffolds to support in vitro expansion of hematopoietic stem cells

Abstract: Hematopoietic stem cell (HSC) expansion offers a key strategy to address the source limitation and donor shortage of HSCs for the treatment of various blood disorders. Specific remodeling of complex...

Cited by 1 publication

References 39 publications

Are we ready to integrate 3D culture systems in acute myeloid leukemia and bone marrow microenvironment research?

Are we ready to integrate 3D culture systems in acute myeloid leukemia and bone marrow microenvironment research?

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