Bone marrow histologic and immunohistochemical findings in peripheral T-cell lymphoma: A study of 38 cases

Gaulard, Philippe; Kanavaros, Panagiotis; Farcet, Jean‐Pierre; Rocha, Francisco Dário; Haı̈oun, Corinne; Diviné, Marine; Reyes, F; Zafrani, Élie Serge

doi:10.1016/0046-8177(91)90081-y

Cited by 59 publications

(25 citation statements)

References 30 publications

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“…Only a few previous reports have described the pathological features of BM involvement by peripheral T-cell lymphomas, and even fewer have included specific features of BM involvement by AITL. In our series of 13 AITL patients, 54% had lymphomatous BM involvement, a frequency similar to previous reports that range from 60-90% (Pangalis et al, 1978;Diebold et al, 1984;Ghani & Krause, 1985;Gaulard et al, 1991;Attygalle et al, 2004;Merchant et al, 2006). The composition of the lymphomatous infiltrate was similar to that seen in involved lymph nodes, consisting of a polymorphous cell population including small lymphocytes, histiocytes, immunoblasts, eosinophils and plasma cells.…”

Section: Discussionsupporting

confidence: 73%

Spectrum of bone marrow findings in patients with angioimmunoblastic T‐cell lymphoma

2007

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SummaryBone marrow (BM) biopsy is often performed early in the evaluation of patients with angioimmunoblastic T‐cell lymphoma (AITL), and may be the first diagnostic tissue sample; yet the BM histopathology associated with this disease has not been well described. In this study, BM specimens from 13 patients with AITL were reviewed. Seven (54%) were involved by AITL, which was characterised by paratrabecular and interstitial polymorphous infiltrates containing cytologically atypical lymphocytes, histiocytes and eosinophils. The neoplastic cells were positive for CD10 and CXCL13 by immunohistochemistry in a subset of cases. As in lymph nodes, the lymphomatous infiltrate in some BMs contained numerous small or scattered large B cells, resembling either benign lymphoid aggregates or T cell rich large B cell lymphoma, respectively. Secondary haematological changes were frequent and presented independent of BM involvement by AITL; these included trilineage haematopoietic hyperplasia and plasmacytosis. When BM biopsy preceded the diagnosis of AITL, these secondary changes were misinterpreted as chronic myeloproliferative disease (n = 2), or plasma cell dyscrasia (n = 2). In two cases, these changes obscured the presence of BM involvement by AITL. The spectrum of BM findings in AITL patients is important to recognise for early and accurate diagnosis in this disease.

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Section: Discussionsupporting

confidence: 73%

Spectrum of bone marrow findings in patients with angioimmunoblastic T‐cell lymphoma

2007

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“…Thus, in our initial experience, as in several previous reports reviewed by Weidmann,37 it appears that the underestimation of bone marrow involvement has led to splenectomy for diagnostic purposes. Improvement in recognizing discrete marrow involvement using immunophenotypic studies 48 has resulted in a change in our diagnostic strategy in HS␥␦TCL, as shown in the present series in which no splenectomies were performed for diagnosis after 1995. We also show that immunohistochemistry in routinely fixed bone marrow biopsy specimens is a satisfactory approach for the identification of the neoplastic lymphocytes, by demonstrating clusters of CD3 ϩ CD5 Ϫ lymphocytes, usually with a CD8 Ϫ , TIA1 ϩ / granzyme B Ϫ nonactivated cytotoxic phenotype and highlighting their sinusal distribution.…”

Section: Discussionmentioning

confidence: 79%

Hepatosplenic T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients

Belhadj

Reyes²,

Farcet³

et al. 2003

Blood

404

399

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We report on the characteristics of 21 patients with hepatosplenic ␥␦ T-cell lymphoma (HS␥␦TCL), an entity recognized since 1994 in the Revised European American Lymphoma (REAL) classification. Median age was 34 years. Patients had splenomegaly (n ‫؍‬ 21), hepatomegaly (n ‫؍‬ 15), and thrombocytopenia (n ‫؍‬ 20). Histopathologic findings were homogeneous and showed the presence of medium-sized lymphoma cells within the sinusoids of splenic red pulp, liver, and bone marrow. Marrow involvement was usually mild but could be demonstrated by phenotyping in all patients. Cells were CD3 ؉ CD5 ؊ , expressed the ␥␦ T-cell receptor, and had a nonactivated cytotoxic cell phenotype (TIA-1 ؉ ,

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“…[30][31][32][33][34][35][36] A few more cases have been documented in studies on particular issues and are not available in detail. [37][38][39] Typical features are sinusoidal infiltration of the liver and sinusal infiltration of the spleen, no lymphadenopathy, an aggressive clinical course, and a predominance of young male adults. 15,29 Despite use of a variety of treatment regimens including bone marrow or peripheral stem cell transplantation it has not been possible to establish an effective treatment.…”

Section: Introductionmentioning

confidence: 99%

Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990

2000

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Peripheral T cell lymphomas are a heterogeneous group of post-thymic, mature lymphoid malignancies, accounting for approximately 10-15% of all non-Hodgkin's lymphomas. A rare entity within this group is represented by hepatosplenic ␥␦ T cell lymphoma, which is characterized by primary extranodal disease with typical sinusoidal or sinusal infiltration of the liver and the spleen, respectively, by expression of the T cell receptor ␥␦ chain, and by a number of other frequent clinicopathological features including aggressive course of disease. In contrast to these common attributes some biologic characteristics such as expression of cytotoxic proteins and cytotoxic activity have been controversial. In this review, clinicopathological, immunophenotypical, molecular biological, cytogenetical and biological findings, and diagnostic and therapeutic difficulties in hepatosplenic ␥␦ T cell lymphoma are discussed. Leukemia (2000) 14, 991-997.

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Bone marrow histologic and immunohistochemical findings in peripheral T-cell lymphoma: A study of 38 cases

Cited by 59 publications

References 30 publications

Spectrum of bone marrow findings in patients with angioimmunoblastic T‐cell lymphoma

Spectrum of bone marrow findings in patients with angioimmunoblastic T‐cell lymphoma

Hepatosplenic T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients

Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990

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