Bone marrow fat

Hardouin, Pierre; Pansini, Vittorio; Cortet, Bernard

doi:10.1016/j.jbspin.2014.02.013

Cited by 91 publications

(74 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bone marrow fat accounts for 7% of the total fat in adults. Although it is not directly correlated to body mass index or body fat, 30,36 bone marrow fat is inversely related to bone volume/mass. 37,38 Bone marrow fat content can be regulated by estrogen, transforming growth factor b (TGFb), and insulin-like growth factor 1 (IGF1).…”

Section: Aging Of Mscsmentioning

confidence: 89%

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

Liu

Xia

2015

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

The aging population and the incidence of aging-related diseases such as osteoporosis are on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human and animal model studies indicate that aging affects two aspects of mesenchymal stem cell (MSC): a decrease in the bone marrow MSC pool and biased differentiation into adipocyte at the cost of osteoblast, which underlie the etiology of osteoporosis. Aging of MSC cells is also detrimental to some non-skeletal tissues, in particular the hematopoietic system, where MSCs serve as a niche component. In addition, aging compromises the therapeutic potentials of MSC cells, including cells isolated from aged individuals or cells cultured for many passages. Here we discuss the recent progress on our understanding of MSC aging, with a focus on the effects of MSC aging on bone remodeling and hematopoiesis and the mechanisms of MSC aging.

show abstract

Section: Aging Of Mscsmentioning

confidence: 89%

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

Liu

Xia

2015

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…In osteoporotic patients and in the context of ageing, an inverse relation between marrow adipose tissue (MAT) and bone mass is now well established (47,48). However, in an- press.endocrine.org/journal/endo imal models, obesity or a high fat diet may trigger various bone responses ranging from preserved bone density (49) to decreased bone mass and quality (50 -52).…”

Section: Discussionmentioning

confidence: 99%

Oleate Abrogates Palmitate-Induced Lipotoxicity and Proinflammatory Response in Human Bone Marrow-Derived Mesenchymal Stem Cells and Osteoblastic Cells

et al. 2015

View full text Add to dashboard Cite

Osteoporosis is a metabolic bone disease associated with unequilibrated bone remodeling resulting from decreased bone formation and/or increased bone resorption, leading to progressive bone loss. In osteoporotic patients, low bone mass is associated with an increase of bone marrow fat resulting from accumulation of adipocytes within the bone marrow. Marrow adipocytes are active secretory cells, releasing cytokines, adipokines and free fatty acids (FA) that influence the bone marrow microenvironment and alter the biology of neighboring cells. Therefore, we examined the effect of palmitate (Palm) and oleate (Ole), 2 highly prevalent FA in human organism and diet, on the function and survival of human mesenchymal stem cells (MSC) and MSC-derived osteoblastic cells. The saturated FA Palm exerted a cytotoxic action via initiation of endoplasmic reticulum stress and activation of the nuclear factor κB (NF-κB) and ERK pathways. In addition, Palm induced a proinflammatory response, as determined by the up-regulation of Toll-like receptor 4 expression as well as the increase of IL-6 and IL-8 expression and secretion. Moreover, we showed that MSC-derived osteoblastic cells were more sensitive to lipotoxicity than undifferentiated MSC. The monounsaturated FA Ole fully neutralized Palm-induced lipotoxicity by impairing activation of the pathways triggered by the saturated FA. Moreover, Ole promoted Palm detoxification by fostering its esterification into triglycerides and storage in lipid droplets. Altogether, our data showed that physiological concentrations of Palm and Ole differently modulated cell death and function in bone cells. We therefore propose that FA could influence skeletal health.

show abstract

“…Due to restrictions on the length of the reference list, the reader is also referred to another review written by our team on the same topic (29).…”

mentioning

confidence: 99%

The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians

Paccou

Hardouin

Cotten

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

We conclude that most human data demonstrate an inverse relationship between BMF and BMD, but data on the relationship with fractures are inconsistent and need further study. In daily practice, the usefulness for clinicians of assessing BMF using magnetic resonance imaging is still limited. However, the perspectives are exciting, particularly in terms of improving the diagnosis and management of osteoporosis.

show abstract

Bone marrow fat

Cited by 91 publications

References 54 publications

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

Oleate Abrogates Palmitate-Induced Lipotoxicity and Proinflammatory Response in Human Bone Marrow-Derived Mesenchymal Stem Cells and Osteoblastic Cells

The Role of Bone Marrow Fat in Skeletal Health: Usefulness and Perspectives for Clinicians

Contact Info

Product

Resources

About