Bone-Marrow Failure Due to Relative Nutritional Deficiency in Cooley's Hemolytic Anemia

Folic acid deficiency in congestive heart failure.

“…The presence of erythroid hyperplasia and bonemarrow megaloblastosis in the congestive heart failure patients studied, and decreased red cell survival in certain instances (4 of 8 patients), is evidence that folic acid requirements in these patients are raised and are not being satisfied (Chanarin, Dacie, and Mollin, 1959;Jandl and Greenberg, 1959). This conclusion is supported by the high urinary excretion of formiminoglutamic acid described in a study analogous to the present investigation (Daly and Rose, 1966).…”

Folate Deficiency in Humans

“…Other conditions in which an increased demand for folate was suggested were sickle-cell anemia in children (Liu, 1974), in which it was not associated with growth retardation as suggested earlier (Watson-Williams, 1962), hemolytic anemia (Jandl and Greenberg, 1959), the Lesch-Nyhan syndrome, in which increased folate may be required to offset failure of hypoxanthine salvage as has been objectively observed in fibroblast cultures (Felix and DeMars, 1969), and in premature infants. Experimental studies in rats, not yet confirmed in humans, suggest that patients on L-dopa therapy may have increased folate requirements (Ordonez and Wurtman, 1974).…”

Multicentric Castleman's disease associated with renal amyloidosis and pure red cell aplasia

“…Several drugs have been implicated, many of which are also associated with aplastic anemia. Nutritional deficiencies [12] and infections with several viruses [13] have been related to the development of red cell aplasia in patients with underlying hemolytic anemia. Parvovirus B19 has been shown to cause PRCA in patients with no underlying hemolytic illness, presumably by infecting and lysing red cell progenitors [14].…”