Bone Marrow Examination: Techniques and interpretation

Hyun, Bong Hak; Gulati, Gene; Ashton, John K.

doi:10.1016/s0889-8588(18)30581-1

Cited by 31 publications

(22 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For bone marrow involved by disease, we used standard diagnostic criteria 3 for different hematologic diseases to establish whether findings on aspirate smears and touch imprints had the same diagnostic implications. Acute myeloid leukemia and acute lymphoblastic leukemia were indicated by the presence of 30% or more blasts.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Touch Imprints With Aspirate Smears for Evaluating Bone Marrow Specimens

et al. 1999

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

“…2 - 3 The touch imprint has been used to detect qualitative changes in bone marrow, including abnormal cells, such as metastatic carcinoma and lymphoma cells, and is frequently used to diagnose megakaryocytc leukemia. [4][5][6][7][8] However, touch imprints usually are not used to evaluate quantitative changes in bone marrow.…”

mentioning

confidence: 99%

Comparison of Touch Imprints With Aspirate Smears for Evaluating Bone Marrow Specimens

et al. 1999

View full text Add to dashboard Cite

“…If the overall incidence of bone marrow dry taps was between 3.9-6.8% as reported (9)(10)(11)(12) (14). Hence, the prevention of harm plays a critical role in medical safety.…”

Section: Correlation Between Anthropometric Data and Thoracic Dimensionmentioning

confidence: 99%

Risk Factors Concerning Sternal Bone Marrow Aspiration and Patient Safety in Japan

et al. 2010

View full text Add to dashboard Cite

“…A parasite density score was determined (Hyun et al 1988). (b) Culture of bone marrow aspirate in NovyMacNeal-Nicolle (NNN) media: Fluid from the bone marrow aspirates was inoculated to NNN medium with rabbit blood agar slant, overlaid with RPMI 1640 (Gibco BRL, NY, USA) (Schur and Jacobson 1987).…”

Section: Methodsmentioning

confidence: 99%

Performance of rK39 immunochromatography and freeze-dried direct agglutination tests in the diagnosis of imported visceral leishmaniasis

2011

View full text Add to dashboard Cite

Visceral leishmaniasis (VL) is one of the neglected tropical diseases that require a global policy for integrated control programs. The disease is fatal if untreated, affects ∼500,000 persons/year, and is most prevalent in poor countries. Treatment is expensive and carries a risk of toxicity. Therefore, sensitive and specific diagnosis of VL is crucial to avoid under- or overdiagnosis. Selecting an appropriate serological diagnostic test is an issue of controversy and depends on geographic location. The study aimed to evaluate the performance of two serological techniques: recombinant antigen K39 (rK39)-immunochromatographic (IC) lateral flow assay (InBios, USA) that uses a recombinant Leishmania antigen K39 and the specific IgG detection by direct agglutination test (DAT, for the diagnosis of imported VL in non-endemic region (Saudi Arabia). The diagnostic accuracy of the two assays was assessed using bone marrow aspiration, direct microscopic examination, and culture on NNN agar as the "gold standard". The bone marrow specimens from Indian, Sudanese, and Bengali patients (n = 98) with suspected VL features were cultured. Thirty-five specimens were positive (36%). The sensitivity and specificity of rK39-IC test were 89% (95% CI 78-99) and 92% (95% CI 85-99), respectively. DAT (with cutoff ≥1:1,600) showed comparable results (sensitivity 94%; 95% CI 87-101 and specificity 95%; 95% CI 90-100). To conclude, the performance of rK39-IC test and DAT is comparable. Both tests are moderately sensitive and specific and could be used to facilitate the global drive to eliminate this disease. The rK39-IC test is a rapid, easy-to-perform test and can be used as a point-of-care diagnostic method.

show abstract

Bone Marrow Examination: Techniques and interpretation

Cited by 31 publications

References 19 publications

Comparison of Touch Imprints With Aspirate Smears for Evaluating Bone Marrow Specimens

Comparison of Touch Imprints With Aspirate Smears for Evaluating Bone Marrow Specimens

Risk Factors Concerning Sternal Bone Marrow Aspiration and Patient Safety in Japan

Performance of rK39 immunochromatography and freeze-dried direct agglutination tests in the diagnosis of imported visceral leishmaniasis

Contact Info

Product

Resources

About