Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats

Zhao, Di; Lei, Junxia; Chen, Rui; Wang, Yu; Zhang, Xiuming; Shu-nong, LI; Xiang, Peng

doi:10.3748/wjg.v11.i22.3431

Cited by 263 publications

(196 citation statements)

References 28 publications

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“…We did not find recovery of liver fibrosis in this experiment. BMC administration could repair injured liver by reducing inflammation, collagen deposition and remodeling [16,17] . In the current study, transplanted mononuclear bone marrow cells could degrade collagen fibers and improve liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats

Cao

Lin²,

Zhong³

et al. 2007

WJG

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AIM:To study the inhibitory effect of mononuclear bone marrow cell (BMC) transplantation on carbon tetrachloride (CCl4) -induced liver fibrosis in rats. METHODS:Rat liver fibrosis models were induced by CCl4 and alcohol administration. After 8 wk, twenty rats were randomly allocated into treatment group (n = 10) and control group (n = 10). BMC were infused into the rats in treatment group via the portal vein, while heparinized saline was infused in control group. CCl4 was hypodermically injected into the rats twice a week for 4 wk. At the end of wk 12, all rats were humanely sacrificed. Liver samples were taken and stained with HE or Masson trichrome. The general conditions, liver fibrosis (hydroxyproline and collagen fibre) and liver pathological grades in rats were evaluated. RESULTS:The general conditions of the rats in treatment group improved markedly, but not in control group. Hydroxyproline was 504.6 ± 128.8 mg/g in treatment group, and 596.0 ± 341.8 mg/g in control group. The percentage of collagen fibre was 3.75% ± 0.98% in treatment group and 5.02% ± 0.44% in control group. There was a significant difference between the two groups (P < 0.05). Liver pathological grade decreased from grade Ⅳ to grade Ⅲ partially i n t r e a t m e n t g r o u p (P < 0 . 0 5 ) w i t h n o o b v i o u s improvement in control group (P > 0.05). There was a significant difference between treatment group and control group (P < 0.05). World

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Section: Discussionmentioning

confidence: 99%

Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats

Cao

Lin²,

Zhong³

et al. 2007

WJG

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“…En el análisis histológico, ésto influye en el diámetro de la vena que se analiza y grosor de la pared de la misma, aunque no en los cambios patológicos La fibrosis y el aumento de rigidez observadas en las venas varicosas, conllevan una deformación de la pared venosa que propicia la incompetencia valvular y reflujo que origina la aparición de varices (26).…”

Section: Discussionunclassified

Untitled

2014

Actual. Med.

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“…Incluso un estudio demuestra en ratas que la infusión de MSCs protege de la aparición de fibrosis respecto al grupo control cuando se inducia la misma por inhibición de la fibrogénesis (26). En otro artículo se evaluó el uso de células madre derivadas de tejido adiposo (ADSCs) como terapia regenerativa en ratones donde se inducía una esteatohepatitis no alcohólica, llegando a la conclusión que podría ser un tratamiento beneficioso para restaurar la función hepática en un hígado enfermo (27).…”

Section: Aplicación De Células Madre En Hepatologíaunclassified

Stem cell treatment in gastroenterology and hepatology

Guirado¹,

Arco²

2014

Actual. Med.

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Tratamiento con células madre en gastroenterología y hepatología ResumenLas células madre están presentes en la mayoría de los tejidos del organismo, permitiendo su renovación perió-dica y su regeneración en caso de producirse un daño tisular. Debido a su capacidad de autorrenovación y de diferenciación en diversos tipos celulares maduros, se están estudiando para el tratamiento de diferentes enfermedades del aparato digestivo, como la enfermedad inflamatoria intestinal, la celiaquía y en el fallo hepático. En esta revisión se incluyen resultados sobre el beneficio de su posible aplicación terapéutica en el campo de la gastroenterología y hepatología, a pesar de que se necesitan muchos más estudios para la comprensión de la biología de las células madre y de su discutida relación con el proceso de carcinogénesis. AbstractStem cells are present in the most human tissues. They have the capabilities of self-renewal and differentiation, allowing the regeneration of a tissue in case of damage. Due to those properties, stem cells have been studied as treatment of numerous gastrointestinal and liver diseases, i.e., inflammatory bowel disease, celiac disease and liver failure. In this review we present results of therapeutic applications of stem cells in fields of gastroenterology and hepatology, even though further studies are needed to better understand biology of stem cells and their controversial role in the carcinogenesis process.

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Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats

Abstract: MSCs treatment can protect against experimental liver fibrosis in CCl4-induced or DMN-induced rats and the mechanisms of the anti-fibrosis by MSCs will be studied further.

Cited by 263 publications

References 28 publications

Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats

Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats

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Stem cell treatment in gastroenterology and hepatology

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