Bone marrow-derived dendritic cells under influence of experimental breast cancer and physical activity

Abdalla, Douglas Reis; Gomes, Bruno Belmonte Martinelli; Murta, E F C; Michelin, Márcia Antoniazi

doi:10.3892/ol.2017.5589

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…Regarding the influence of physical activity on the immune system in the presence of tumors, preclinical and clinical studies show that practicing physical activity changes the patterns of immune responses to antitumor cellular profiles, at systemic and intratumoral levels, leading to the control of the inflammatory state and potentiating a response of rejection to the tumor, with synthesis of cytokines of profile 1 of T helper lymphocytes, profile 1 of macrophages and improving the maturation of dendritic cells [17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Influence of Physical Activity in Patients with Prostate Cancer Undergoing Radiotherapy and/or Hormonal Deprivation Therapy: Integrative Literature Review

Ávila¹,

Dias²,

Pereira³

et al. 2021

Int J Sports Exerc Med

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Introduction: In Brazil and in the world, the incidence and prevalence of prostate cancer have been increasing. The prostate is a male gland responsible for the production of part of the semen. More than any other type, it is considered a cancer of the third age, since about 75% of the cases in the world occur from the age of 65. In this study it was correlated the practice of physical exercises with the progression and evolution of the disease beyond the impacts in the treatment.Aim: This work aimed to verify in the literature the impacts of regular physical activity on patients with prostate cancer under treatment and after treatment.Methods: Systematic search of scientific articles published between 2010 and 2020 in the PubMed database, using the descriptors: Prostate cancer, Physical activity, Exercise, Quality of life and Lifespan. After complete analysis of the publications, seven articles met all inclusion criteria. Results: Overall improvement was observed in those patients who started the physical activity program, as well as improvement in quality of life, physical function, weight, body fat, well-being-psychological and reduction of cardiovascular risk, weight, fatigue, blood markers and inflammatory cytokines. Conclusion:Physical activity is an additional resource in the treatment of patients with prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Influence of Physical Activity in Patients with Prostate Cancer Undergoing Radiotherapy and/or Hormonal Deprivation Therapy: Integrative Literature Review

Ávila¹,

Dias²,

Pereira³

et al. 2021

Int J Sports Exerc Med

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“…Concerning the investigation of mDC maturation in animals with induced immunosuppression subjected to physical activity, the percentage of DCs increased in trained groups with and without immunosuppressants, associated with higher CD80, CD86, and MHC-II expression levels when compared to untrained animals. Moreover, IFN-γ and IL-12 cytokines may be upregulated in exercised mice, with physical exercise suggested as an inducer of differentiation and maturation of DCs, even within an immunosuppressive environment, in association with the Th1 profile [63]. Regarding the Th2 response, in an experimental study based on the OVA-induced asthma model, moderate physical exercise modulated allergic pulmonary inflammation, increasing Treg and M2 recruitment and pDC activation [28].…”

Section: Physical Activity and Immune Responsementioning

confidence: 99%

Why Physical Activity Should Be Considered in Clinical Trials for COVID-19 Vaccines: A Focus on Risk Groups

Bortolini

Petriz

Mineo

et al. 2022

IJERPH

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Since the World Health Organization declared the global COVID-19 state of emergency in early 2020, several vaccine candidates have emerged to control SARS-CoV-2, and some of them have been approved and implemented in vaccination campaigns worldwide. Although clinical trials for these vaccines have been carried out using highly controlled methods with accurate immunological tests, clinical questionnaires did not include questions concerning the physical activity profile among volunteers. It has been well established that physical activity plays a pivotal role in the immune response after vaccination, led by the activation of cytokines, antibodies, and cells. This concept should have been considered when evaluating the efficacy of COVID-19 vaccine candidates, particularly in elderly and obese people. Here, we discuss data from the literature providing strong evidence regarding the importance of analyzing physical activity parameters to improve the accuracy of clinical trials on assessing the efficacy of vaccine candidates.

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Physical Activity and COVID-19 Vaccines

Gasmi

Nehaoua

Noor

et al. 2023

Physical Activity and Pandemics

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Bone marrow-derived dendritic cells under influence of experimental breast cancer and physical activity

Cited by 5 publications

References 22 publications

Influence of Physical Activity in Patients with Prostate Cancer Undergoing Radiotherapy and/or Hormonal Deprivation Therapy: Integrative Literature Review

Influence of Physical Activity in Patients with Prostate Cancer Undergoing Radiotherapy and/or Hormonal Deprivation Therapy: Integrative Literature Review

Why Physical Activity Should Be Considered in Clinical Trials for COVID-19 Vaccines: A Focus on Risk Groups

Physical Activity and COVID-19 Vaccines

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