Bone marrow-derived cells and the vasculature in diabetes: from biomarker to treatment?

An underlying principle for the study of circulating progenitor cells in diabetes and its complications

“…Thus, disparate EPC phenotypes continue to be used, and results are not always consistent, such that direct comparison of studies is not always possible. Moreover, attributing a biological function to a relatively simple antigenic phenotype is an abstraction that may not always hold true, as highlighted in a recent commentary published in Diabetologia [8]. Unfortunately, there are also a wide variety of methods used to isolate and culture EPCs, which can produce different, even conflicting, results and interpretations [9,10].…”