Bone Marrow-Derived B Cells Preserve Ventricular Function After Acute Myocardial Infarction

Abstract

Intramyocardial injection of B cells into early post-ischemic myocardium preserved cardiac function by cardiomyocyte salvage. Other BM MNC subtypes were either ineffective or suppressed cardioprotection conferred by an enriched B cell population.

Role of Lymphocytes in Myocardial Injury, Healing, and Remodeling After Myocardial Infarction

“…58 This study could not delineate a definite mechanism for B-cells' beneficial influence. The role of B-cells after MI was recently investigated using several B-cell ablation strategies in a permanent MI mouse model.…”

Effect of Monocyte-to-Lymphocyte Ratio on Heart Failure Characteristics and Hospitalizations in a Coronary Angiography Cohort

“…26 Conflicting evidence with respect to their relation to cardiac remodeling 27,28 emphasizes that our understanding of the role of B cells is still in its infancy.…”

The cellular immune system in the post-myocardial infarction repair process

“…Local injection of bone marrow-derived B cells in the early ischaemic heart of LAD-ligated rats significantly improved myocardial salvage and, hence, provided a better ventricular function [118]. However, depletion of B cells in LAD-ligated mice by injecting an antibody against CD20 resulted into less recruitment of Mon1 with a smaller infarct size, less fibrosis, a reduction in apoptotic cells and improved cardiac function as a result (Fig.…”